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1. Lee WC, Lin KY, Chen CM, Chen ZT, Liu HJ, and *Lai YK. 1991. Induction of heat-shock response and alteration of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells. Journal of Cellular Physiology 149:66-76. (SCI) NSC-80-0418-B-007-01
2. Lee WC, Liu HC, Pan DHC, Jou TC, and *Lai YK. 1992. Cell survival and Heat shock protein synthesis of normal and malignant rat brain cells during and after hyperthermia. Journal of Thermal Biology 17:33-43. (SCI) NSC-80-0418-B-007-01
3. Lee WC, Lin KY, Chen KD,and *Lai YK. 1992. Induction of HSP70 is associated with vincristine resistance in heat-shocked 9L rat brain tumor cells. British Journal of Cancer 66:653-659. (SCI) NSC-81-0418-B-007-01
4. Lee WC, Yu JS, Yang SD, and *Lai YK. 1992. Reversible hyperphosphorylation and reorganization of vimentin intermediate filaments by okadaic acid in 9L rat brain tumor cells. Journal of Cellular Biochemistry 49:378-393. (SCI) NSC-81-0211-B-007-04
5. Lee WC, Lee YC, Perng MD, Chen CM, and *Lai YK. 1993. Induction of vimentin modification and vimentin-HSP72 association by withangulatin A in 9L rat brain tumor cells. Journal of Cellular Biochemistry 52:253-265. (SCI) NSC-82-0211-B-007-04
6. *Lai YK, Shen CH, Cheng TJ, Hou MC, and Lee WC. 1993. Enhanced phosphorylation of a 65 kDa protein is associated with rapid induction of stress protein in 9L rat brain tumor cells. Journal of Cellular Biochemistry 51:369-379. (SCI) NSC-82-0211-B-007-04
7. *Lai YK, Lee WC, and Chen KD. 1993. Vimentin serves as a phosphate sink during the apparent activation of protein kinases by okadaic acid in mammalian cells. Journal of Cellular Biochemistry 53:161-168. (SCI) NSC82-0211-B-007-004 8. Hou MC, Shen CH, Lee WC, and *Lai YK. 1993. Okadaic acid as an inducer of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells. Journal of Cellular Biochemistry 51:91-101. (SCI) NSC-82-0211-B-007-04
9. Lee WC, Ferrero GB, Chinault AC, *Yen PH, and Ballabio A. 1993. A yeast artificial chromosome contig linking the steroid sulfatase and Kallmann syndrome loci on the human X chromosome short arm. Genomics 18:1-6. (SCI)
10. Huang TJ, Lee TJ, Lee WC, Lai YK, Yu JS, and *Yang SD. 1994. Autophosphorylation-dependent protein-kinase phosphorylates Ser(25), Ser(38),Ser(65),Ser(71),and Ser(411),in vimentin and thereby Inhibits cytoskeletal intermediate filament assembly. Journal of Protein Chemistry 13:517-525. (SCI) NSC-82-0203-B-007-29
11. Lee WC, Salido E, and *Yen PH. 1994. Isolation of the GS1 (DXS 1283E) gene from a CpG island between STS and KAL on the distal short arm of the human X chromosome. Genomics 22:372-376. (SCI)
12. Lai YK, Lee WC, Hu CH, and *Hammond GL. 1996. The mitochondrion are sensory organelles for cell stress recognition. Journal of Surgical Research 62:90-94. (SCI) NSC-84-2311-B-007-033-B12
13. *Lee WC, Lin KY, Chiu YT, Lin JH, Cheng HC, Huang HC, Yang PC, Lu S, and Mao SJT. 1996. Substantial decrease of HSP90 in ventricular tissue of two sudden death pigs with hypertrophic cardiomyopathy. FASEB Journal 10:1198-1024. (SCI) NSC-84-2321-B-059-001
14. Huang HC, *Lee WC, Cheng IC, and Yang PC. 1996. Isolation, characterization and transcription of collagen genes of porcine cardiac fibroblasts. Journal of Chinese Society of Veterinary Science 22:281-294. (in Chinese)
15. Huang HC, *Lee WC, Cheng HC, Mao SJT, and Yang PC. 1996. Isolation, characterization and heat shock protein synthesis of porcine synthesis of porcine aortic smooth muscle cells. Journal of Chinese Society of Veterinary Science 22:256-269. (in Chinese)
16. *Huang, SY, Tsou HL, Lee WC, and Lee YP. 1997. The effects of heat stress on pig production. Scientific Agriculture 45:315-319. (in Chinese)
17. Chu LFN, Lee WC, Yang PC, Chu RM, Huang TY, and *Mao SJT. 1997. One-step HPLC purification procedure for porcine brain 90-kDa heat shock protein. Protein Expression and Purification 10:180-184. (SCI) NSC-84-2321-B-059-001-A20
18. Huang HC, *Lee WC, Chen SP, Yang PC, and Mao SJT. 1997. Phenotypic modulation of smooth muscle cells from porcine aorta. Journal of the Chinese Society of Veterinary Science 23:293-302. (in Chinese)
19. Huang HC, *Lee WC, Cheng HC, Yang PC, and Mao SJT. 1997. Synthesis of heat shock protein 70 in cardiac fibroblast from porcine embryo. Journal of the Chinese Society of Veterinary Science 23:241-349. (in Chinese)
20. *Huang, SY, Lee WC, Lee YP and Tsou HL. 1998. The relationship between heat shock proteins and thermotolerance. Scientific Agriculture 46:260-264. (in Chinese)
21. Lin JH, Wang YH, *Lee WC, Lee ST, Lee ST, Lin KY, Cheng HC, Lin PH, Huang HC, Pang SC, Mao SJT, Yang PC, and Chu R. 1998. The establishment of SPF pigs model in understanding protective mechanism of myocardial ischemia. Journal of the Chinese Society of Veterinary Science NSC-86-2321-B-059-005 (in press) (in Chinese)
22. Huang HC, *Lee WC, Lin JH, Huang HW, Jian SC, Mao SJT, Yang PC, Huang TY, and Liu YC. 1998. Molecular cloning and characterization of porcine cDNA encoding a 90-kDa heat shock protein and its expression following hyperthermia. Gene (SCI) NSC-86-2321-B-059-013-A20; NSC-87-2321-B-059-021-A20 (in press)
23. Huang SY, Kuo YH, Lee WC, Tsou HL, Lee YP, Chang HL, Wu JJ, and Yang PC. 1998. Substantial decrease of heat-shock protein 90 precedes the decline of sperm motility during cooling of boar spermatozoa. Theriogenology (SCI) (in press)
24. King YT, Lee WC, Gao MS, Wang JL, *Kuo YH. 1998. Stage-specific protein synthesis in early embryogenesis in pigs. Theriogenology (SCI) (revised)
25. Dai KS, Lee WC, Liu SK, Huang TY, Chiu YT, Chien SP, Yang PC, Chu R, and *Mao SJT. 1998. Ultrastructural alterations in myocardium associated with hypertrophic cardiomyopathy. Journal of Pathology (submitted) (SCI)
26. *Lee WC, Lin KY, Huang HC, Chiang AN, Huang TY, Mao SJT, AND Yang PC. 1998. Induction of HSP70 gene expression by okadaic acid in porcine neonatal cardiomyocytes. Journal of Cellular Biochemistry (SCI) (in preparation) 27. *Lee WC, Lin JH, Wang YH, Lee ST, Cheng HC, Lin CS, Huang JP, Lin PH, Huang HC, Chu R, Sun JL, Mao SJT. 1998. Attenuation of a-smooth muscle actin and changes in antloxidant activitics in porcine myocardium following ischemia and reperfusion. Journal of Cellular Biochemistry (SCI) (in preparation)
28. Lee WC, Hwang KP, King YT, Chen HC, Tsay CC, Chiou SS, Wu JR, Yu JS, Dai ZK, Huang MY, Yang RC, and *Huang TY. 1998. Diagnostic value of alpha2-haptoglobin and apolipoprotein A-I for Kawasaki disease. Pediatric Research (SCI) (in preparation)

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1. Lee WC, and Lai YK. 1990. A Topoisomerase II Poison, Withangulatin A, Intiates Heat-Shock Like Response in Mammalian Cells. Proceedings of the Third International Symposium and Workshop of the Society of Chinese Bioscientists in America. pp.355.
2. Lee WC, Chen CM, and Lai YK. 1991. Cellular and Biochemical Effects of Withangulatin A in Mammalian Cells. Symposium on Natural Products and Medicinal Chemistry. pp.15.
3. Lai YK, and Lee WC. 1992. Reversible Hyperphosphorylation and Reorganization of Vimentin Intermediate Filaments by Okadaic Acid in 9L Rat Brain Tumon Cells. Proceedings of the Forth International Symposium and Workshop of the Society of Chinese Biosoientists in America. Pp. 154.
4. Lee WC, Ferrero GB, Chinault AC, Yen PH, and Ballabio A. 1993. A Yeast Artificial Chromosome Contig Linking the Steroid Sulfatase and Kallmann Syndrome Loci on the Human X Chromosome Short Am. Fourty-third Annual Meeting of The American Society of Human Genetics.
5. Lee WC, and Lin JH. 1994. Pig Model for Comparative Medical Research. Proceedings of The First Asian-Pacific Chinese Swine Meeting. Pp. 379-387. Chunan, Miaoli, Taiwan.
6. Huang HH, Lee WC, and Chen HC. 1995. Identification of smooth muscle cells in primary culture from porcine aorta. Taiwan Journal of Veterinary Medicine and Animal Husbandry 65(Suppl 2): 8 (in Chinese)
7. Lee WC, Lin KY, Chiu YT, Lin JH, Cheng HC, Yang PC, Lin SK, and Mao SJT. 1995. Substantial Decrease of Heat Shock Protein 90 in Ventricular Tissues of Two Sudden Death Pigs with Hypertrophic Cardiomyopathy. The 1995 Annual Scientific Meeting, the Society of Lipids and Atherosclerosis, R.O.C. pp. 20.
8. Mao SJT, Yu PR, Chiu YZ, Lin JH, Wang YH, Dai KS, Yang PC, and Lee WC. 1995. Role of Plasma Lipoproteins in Intramural Coronary Artery Disease in Pigs with Hypertrophic Cardiomyopathy. The 1995 Annual Scientific Meeting, the Society of Lipids and Atherosclerosis, R.O.C. pp. 20.
9. Lee WC, Wang YH, Lee ST, Lin JH, Lin KY, Chang JJ, Lin PH, Yang PC, Pang SC, and Mao STJ. 1995. The Establishment of a Porcine Model for Studying Molecular Mechanism of Ischemic Preconditioning: a Preliminary Report. Symposium of 1995 Comparative Medicine in Cardiovascular Disease. Pp. 13.
10. Huang HW, Chen HC, and Lee WC. 1995. The Relationship between Heat Shock Proteins and Sudden Death in Pigs. Symposium of 1995 Comparative Medicine in Cardiovascular Disease, pp. 16.
11. Huang HC, Lee WC, and Mao SJT. 1995. The Effect of Growth Factors on Collagen Gene Transcription of Cardiac Fibroblast. Symposium of 1995. Comparative Medicine in Cardiovascular Disease, pp. 20.
12. Huang HC, and Lee WC. 1996. The differential marker of porcine aortic smooth muscle cells. Expression of £\-smooth muscle actin. Journal of the Chinese Society of Veterinary Science 22: A44 (in Chinese).
13. Lee WC, Lin JH, Wang YH, Lee ST, Cheng HC, Lin CS, Huang JP, Lin PH, and Mao JTM. 1996. Depletion of £\-smooth muscle actin and changes in antioxidant activities in porcine myocardium following ischemia and reperfusion. Journal of the Chinese Society of Veterinary Science 22:A45.
14. Lee WC, Lin KY, Huang HC, Chiang AN, Huang TY, and Mao SJT. 1996. Cell-type specific induction of HSP70 gene expression by okadaic acid porcine neonatal cardiomyocytes: A novel pharmacological route to protect myocardium? Acta Paediatrica Sinica 37 (Suppl B): 122.
15. Yang PC, Lee WC, Lin JH, and Wang YH. 1996. Establishment of a porcine model for studying myocardial ischemic preconditioning by using specific pathogen free pigs. Symposium of 1996 R.O.C.-Japan for Experimental Animals, pp. 23-24.
16. Mao SJT, Chen TTS, Chiu YT, Lin JH, Huang HC, and Lee WC. 1996. Smooth muscle cell proliferation intramura coronary artery of hypertrophic cardiomyopathy. The 1996 Annual Scientific Meeting, the Society of Lipid and Atherosclerosis, R.O.C., pp. 20.
17. Huang HC, Lee WC, Huang TY, and Mao SJT. 1997. Alteration of Alpha-Smooth Muscle Actin during Phenotypic modulation of Smooth Muscle Cells. Acta Paediatrica Sinica 38 (Suppl A): 111.
18. Huang SY, Kuo YH, Tsou HL, Lee YP, Chang HL, Wu JJ, King YZ, Lin EC, and Lee WC. 1997. Substantial decrease of heat shock protein 90 in frozen-thawed boar spermatozoa. Journal of Chinese Society of Animal Science 26(Suppl.):73.
19. Huang SY, Kuo YH, Lee WC, TsouHL, Lee YP, Chang HL, Wu JJ, and Yang PC. 1998. Decrease of heat-shock protein 90 is associated with boar semen characteristics during the preparation of frozen semen. Proceed. The 8th World Conference on Animal Production, Contributed papers-Vol.II:260-261.
20. Kuo YH, Huang SY, Lee WC, and Chen MY. 1998. Frozen boar semen in the absence or presence of catalase. Proceed. The 8th World Conference on Animal Production, Contributed Paper-VolII:864-865. June 28-July 4, Seoul, Korea.
21. Huang HC, Lee WC, Lin JH, Huang HW, Jian SC, and Liu YC. 1998. Molecular cloning and characterization of porcine cDNA encoding a 90-kDa heat shock protein and its expression following hyperthermia. 1998 Annual Meeting for American Society for Biochemistry and Molecular Biology, Late Breaking Abstract A25, Washington DC.
22. Lee WC, Hwang KP, Tsay CC, Chen HC, King YT, Chiou SS, Yang RC, Mao SJT, Huang TY. 1998. Haptoglobin Polymorphism and Kawasaki Disease in Taiwan. 1998 Annual Meeting for American Society for Biochemistry and Molecular Biology, Late Breaking Abstract A25, Washington DC.

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1. Lee WC. 1991. Cellular and Biochemical Studies on Heat-Shock Response Induced by Elevated Temperature and Withangulatin A. Ph.D. Dissertation, National Tsing Hua University, Hsingchu, Taiwan, R.O.C.
2. Huang HW, Jian SC, Huang HC, *Lee WC. 1997. Complete mucleotide sequence of a porcine cDNA for 90-kDa heat shock protein. Geobaok/NCBI Accession number U94395(NSC-86-2321-B-059-013-a20) ¶@6‚**Ÿ6‚*