typically begins with subtle and poorly recognized failure of memory. Slowly,
over a period of years, the memory loss becomes more severe and eventually
incapacitating. Other common symptoms include confusion, poor judgment,
language disturbance, agitation, withdrawal, and hallucinations. Some patients
may develop seizures, Parkinsonian features, increased muscle tone, myoclonus,
incontinence, and mutism . Death usually results from general inanition,
malnutrition, and pneumonia. The typical clinical duration of the disease
is 8-10 years with a wide-range of 1-25 years.