Phospholipase family :
PLA2 is very important for essential fatty acid degradation from R2 arm of glycerophospholipid. PLC is important in signal transduction. |
PLCs are usually involved in phospholipid signal transduction. Like PI cascade. PIP2 is hydrolysed by PLC and converts to DAG(1,2-Diacylglycerol) and IP3. Since DAG is a second messenger, DAG can activate PKC. On the other hand, IP3 makes Ca2+ releasing from CaM. And Ca2+ also as a second messenger. |