SCI Publications:

more in PubMed


1. Ling Chien, Min-Zong Liang, Chu-Yuan Chang, Chen Wang, Linyi Chen* (2018) Mitochondrial therapy promotes regeneration of injured hippocampal neurons. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,  in press

2. Ya-Jean Wang, Chung-Pin Hsieh, Ming-Huan Chan, Tzu-Yi Chan, Linyi Chen, Hwei-Hisen Chen (2018) Distinct effects of resveratrol on seizures and hyperexcitability induced by NMDA and 4-aminopyridine. Nutritional Neuroscience DOI: 10.1080/1028415X.2018.1461458


1. Kuan-Wei Chen, Yu-Jung Chang, Chia-Ming Yeh, Yen-Ling Lian, Michael W. Y. Chan, Cheng-Fu Kao, Linyi Chen*. (2017) SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1860, 2, pp270-281

2. Kuan-Wei Chen and  Linyi Chen* (2017) Epigenetic Regulation of BDNF Gene during Development and Diseases International Journal of Molecular Sciences,18,pp571

3.Chien-Hung Shih, Yu-Jung Chang, Wei-Chieh Huang, Te-Hsuan Jang, Hsing-Jien Kung, Wen-Ching Wang, Muh-Hwa Yang, Meng-Chin Lin, Shiu-Feng Huang Shu-Wei Chou, Emily Chang, Hsn Chiu, Tien-Yu Shieh, Yu-Jen Chen, Lu-Hai Wang, Linyi Chen*. (2017) EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis. Oncogene, 36(47):6542-6554



1. Ya-Jean Wang, Ming-Huan Chan, Linyi Chen, Sheng-Nan Wu, Hwei-Hsien Chen. (2016) Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels. Journal of Biomedical Science, 23, pp47

2. Tim Ting-Chung Yen, Anderson Yang, Wen-Tai Chiu, Kuan-Ying Lu, Lyu-Han Wang, Hui-Chen Wang, Linyi Chen, Wen-Ching Wang, Wenya Huang, Meng-Ru Shen, Ih-Jen Su, and Lily Hui-Ching Wang. (2016) Hepatitis B Virus PreS2-mutant Large Surface Antigen Modulates Store-Operated Calcium Entry and thereby Promotes Chromosome Instability. Oncotarget, 7, 17, pp23346-23360

3. Da-Wei Yeh, Yu-Syuan Chen, Chao-Yang Lai, Yi-Ling Liu, Chih-Hao Lu, Jeng-Fan Lo, Linyi Chen, Li-Chung Hsu, Yunping Luo, Rong Xiang and Tsung-Hsien Chuang. (2016) Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells, Cell Death and Differentiation, 23(5):841-52



1. Chien-Jen Chen, Chien-Hung Shih, Yu-Jung ChangTian-Neng Li, Lily Hui-Ching Wang, Shao-Jing Hongand Linyi Chen* (2015) SH2B1 and IRSp53 promotes the formation of dendrites and dendritic branches. Journal of Biological Chemistry, 290(10):6010-21

2. Kuan-Wei Chen, Yu-Jung Chang, and Linyi Chen* (2015) SH2B1 orchestrates signaling events to filopodium formation during neurite outgrowth. Communicative & Integrative Biology 8(4), e1044189

3. Ling Chien, Wun-Ke Chen, Szu-Ting Liu, Chuang-Rung Chang, Mou-Chieh Kao, Kuan-Wei Chen, Shih-Che Chiu, Ming-Ling Hsu, I-Chou Hsiang, Yu-Jen Chen, and Linyi Chen* (2015) Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons. Oncotarget, 6,31,pp30628-30639.

4. Li-Jing Chen, Li Chuang, Yi-Hsuan Huang, Jing Zhou, Seh Hong Lim, Chih-I Lee, Wei-Wen Lin, Ting-Er Lin, Wei-Li Wang, Linyi Chen, Shu Chien, and Jeng-Jiann Chiu. (2015) MicroRNA Mediation of Endothelial Inflammatory Response to Smooth Muscle Cells and its Inhibition by Atheroprotective Shear Stress. Circulation Research,116(7): 1157–1169.



1. Yu-Jung Chang, Kuan-Wei Chen, Ching-Jen Chen, Ming-Hsing Lin, Yuh-Ju Sun, Jia-Lin Lee, Ing-Ming Chiu, and Linyi Chen*. (2014) SH2B1b interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. Molecular and Cellular Biology, 34(6): 1003-1019.

2. Rajesh Raju, Shyam Mohan Palapetta, Varot K. Sandhya, Apeksha Sahu, Abbas Alipoor, Lavanya Balakrishnan, Jayshree Advani, Bijesh George, K. Ramachandra Kini, Geetha N. Prashanth, H. S. Prakash, T. S. Keshava Prasad, Yu-Jung Chang, Linyi Chen, Akhilesh Pandey, H. C. Harsha. (2014) A network map of FGF-1/FGFR signaling system. Journal of Signal Transduction, volume 2014, article ID 962962.

3. Yi-Chao Hsu, Su-Liang Chen, Ya-Jean Wang, Yun-Hsiang Chen, Dan-Yen Wang, Linyi Chen, Chia-Hsiang Chen, Hwei-Hsien Chen, and Ing-Ming Chiu (2014) Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem Cells Translational Medicine, 3:1-10. 

4. Meng-Ling Wu, Chung-Huang Chen, Yung-Tsang Lin, Yuan-Jyun Jheng, Yen-Chun Ho, Liang-Tung Yang, Linyi Chen, Matthew D Layne and Shaw-Fang Yet. (2014) Divergent signaling pathways cooperatively regulate TGFbeta induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Communication and Signaling, 12:22.

5. Shao-Jing Hong, Szu-Ting Liu, Chien-Jen Chen and Linyi Chen*. (2014) SH2B1 increases the numbers of IRSp53-induced filopodia. Biochimica et Biophysica Acta-General Subjects 1840:3335-3344.



1. Yi-Wen Chen, Hsiu-Chuan Chou, Szu-Ting Lin, You-Hsuan Chen, Yu-Jung Chang, Linyi Chen, and Hong-Lin Chan. (2013) Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine 2013: 364519.

2. Yu-Jung Chang, Che-Ming Hsu, Chia-Hua Lin, Michael Shiang-Cheng Lu and Linyi Chen*. (2013) Electrical stimulation promotes nerve growth factor-induced neurite outgrowth and signaling. Biochimica et Biophysica Acta-General Subjects 1830(8):4130-4136.

3. Ching-Yu Lin, Chieh Huo, Li-Kuo Kuo, Richard A. Hiipakka, Richard Baker Jones, Hui-Ping Lin, Yuwen Hung, Liang-Cheng Su, Jen-Chih Tseng, Ying-Yu Kuo, Yu-Ling Wang, Yasuhisa Fukui, Yung-Hsi Kao, John M. Kokontis, Chien-Chih Yeh,Linyi Chen, Shiaw-Der Yang, Hsiao-Hui Fu, Ya-Wen Chen, Kelvin K.-C. Tsai Jang-Yang Chang, Chih-Pin Chuu* (2013) Cholestane-3beta, 5alphs, 6alpha-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells,PLoS ONE,8(6):e65734.

4. Chien-Hung Shih, Chien-Jen Chen, and Linyi Chen* (2013) New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth,PLoS ONE,8,(11):e79619.



1. Yu-Tsung Shih, Mei-Cun Wang, Hsin-Hsin Peng, Ting-Fang Chen, Linyi Chen, Jang-Yang Chang, Jeng-Jiann Chiu. (2012) Modulation of chemotactic and pro-inflammatory activities of endothelial progenitor cells by hepatocellular carcinoma. Cellular Signalling, 24: 779-793.

2. Chia-Ling Wu, Yu-Han Chou, Yu-Jung Chang, Nan-Yuan Teng, Hsin-Ling Hsu, Linyi Chen.* (2012) Interplay between cell migration and neurite outgrowth determines SH2B1b-enhanced neurite regeneration of differentiated PC12 cells. (*corresponding author,  PLoS ONE, 7(4):e34999

3. Hung-Ju Shih, Hsiao-Huei Chen, Yen-An Chen, Meng-Hsun Wu, Gan-Guang Liou, Wei-Wen Chang, Linyi Chen, Lu-Hai Wang, Hsin-Ling Hsu. (2012) Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity.  Oncotarget 3, 1401-1415.



1. Tien-Cheng Wang, Yi-Hsuan Li, Kuan-Wei Chen, Ching-Jen Chen, Chia-Ling Wu, Nan-Yuan Teng, Linyi Chen*. (2011) SH2B1b regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation. Journal of Cellular Physiology, 226: 2063–2074. (* corresponding author) Selected in “Highlights” of the issue.

2. Chia-Lin Wu, Meng-Fu Maxwell Shih, Jason Sih-Yu Lai, Hsun-Ti Yang, Glenn C. Turner, Linyi Chen, and Ann-Shyn Chiang. (2011) Heterotypic gap junctions between two neurons in the Drosophila brain are critical for memory. Current Biology, 21, 1-7

3. Tien-Cheng Wang, Hsun Chiu, Yu-Jung Chang, Tai-Yu Hsu, Ing-Ming Chiu and Linyi Chen* (2011) The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons. PLoS ONE, 6(10): e26433. (*corresponding author)



1.  Wan-Chen Lu, Chien-Jen Chen, Hui-Chien Hsu, Hsin-Ling Hsu and Linyi Chen*. (2010) The adaptor protein SH2B1b reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons. Journal of Molecular Signaling 5: 17 (* corresponding author)

2. Ravi Kasiappan, Hung-Ju Shih, Meng-Hsun Wu, Chik On Choy, Tai-Du Lin, Linyi Chen and Hsin-Ling Hsu. (2010) The antagonism between MCT-1 and p53 affects the tumorigenic outcomes. Molecular Cancer 9:311.



1. Wei-Fan Lin, Chien-Jen Chen, Yu-Jung Chang, Su-Liang Chen, Ing-Ming Chiu, Linyi Chen* (2009) SH2B1b enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.  Cellular Signalling 21:1060-1072. (* corresponding author)

2. Travis J. Maures, Linyi Chen, and Christin Carter-Su (2009) Nucleocytoplasmic shuttling of the adaptor protein SH2B1b (SH2-Bb) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes. Molecular Endocrinology 23(7): 1077-1091



1. Chen, L ., Maures, T. J., Jin, H., Huo, J. S., Rabbani, S. A., Schwartz, J. and Carter-Su, C. (2008) SH2B1b (SH2-Bb) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plaminogen activator receptor and matrix metalloproteinase 3/10. Molecular Endocrinology 22(2):454-476.

2. Li, H., Shih, W-H., Shih, W-Y., Chen, L., Tseng, S-J., and Tang, S-C. (2008) Transfection of aqueous CdS quantum dots using polyethylenimine. Nanotechnology 19: 475101-475108.



1. *Wang, X., *Chen, L., *Maures, T., Herrington, J., and Carter-Su, C. (2004) SH2-B is a positive regulator of Nerve Growth Factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. Journal of Biological Chemistry, 279(1): 133-141. (* These authors contribute equally.)

2. Sun, B., Chen, L., and Davis, N. G. (2004) The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXF adaptin sorting signal. Molecular Biology of the Cell, 15: 1397-1406.

3. Linyi Chen and Christin Carter-Su (2004) Adaptor protein SH2-Bb undergoes nucleo-cytoplasmic shuttling: Implications for Nerve Growth Factor induction of neuronal differentiation. Molecular and Cellular Biology, 24(9): 3633-3647.

4. Sipos, G., Brickner, J. H., Brace, E. J., Chen L., Rambourg, A., Kepes, F. and Fuller, R. S. (2004) Soi3/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of Trans-Golgi network transmembrane proteins. Molecular Biology of the Cell, 15(7): 3196-3209.



1. Chen, L. and Davis, N. G. (2002) Ubiquitin-independent entry into the yeast recycling pathway. Traffic, 3(2): 110-23.

2. Roth, A.F., Feng, Y., Chen, L., and Davis, N. G. (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. Journal of Cell Biology, 159(1): 23-28. (SCI)

3. Chen, L. and Davis, N. G. (2000) Recycling of the yeast a-factor receptor. Journal of Cell Biology, 151(3): 731-738.

4. Yang, S-C, Lin, J-G, Chiou, C-C, Chen, L-Y, Yang, J-L. (1994) Mutation specificity of 8-methoxypsoralen plus two doses of UVA irradiation in the HPRT gene in diploid human fibroblasts. Carcinogenesis, 15(2), 201-207.