Recent Publications (From year 2010-2014), *corresponding author

-4) Li-Sheng Chang, Chih-Hsiang Leng, Yi-Chen Yeh, Chiao-Chieh Wu, Hsin-Wei Chen, Hai-Mei Huang* and Shih-Jen Liu*, Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy, Molecular Cancer 2014, 13:60 ;

-3) Ju-Ying Tsai, Mon-Juan Lee, Margaret Dah-Tsyr Chang*, and Haimei Huang*, The effect of catalase on migration and invasion of lung cancer cells by regulating the activities of cathepsin S, L, and K, Experimental Cell Research (2014) 323: 28-40, (Accepted, Feb. 2014).

-2) Chiao-Yuan Fan, Hsiu-Chuan Chou, Yi-Wen Lo, Yueh-Feng Wen, Yi-Chih Tsai, Haimei Huang and Hong-Lin Chan*,2014,Proteomic and redox-proteomic study on the role of glutathione reductase in human lung cancer cells, Electrophoresis 2013, 34, 3305–3314, DOI 10.1002/elps.201300250

-1) Tsai, Ju-Ying; Lee, Mon-Juan; Chang, Margaret Dah-Tsyr*; Wang, Hsin-Chieh; Lin, Chun-Cheng; Huang, Haimei* , Effects of Novel Human Cathepsin S Inhibitors on Cell Migration in Human Cancer, Journal Of Enzyme Inhibition And Medicinal Chemistry Cells (Accepted, June, 2013). In ePub.;


1. Mon-Juan Lee , Ya-Ting Yang, Vivian Lin and Haimei Huang*, Site-directed mutations of the gatekeeping loop region affect the activity of Escherichia coli spermidine synthase. Molecullar Biotechnology (2013) 54(2), 572-580.

2. Yi-Chih Tsai, Yi-Hsiang Wang, Chih-Chiang Liou, Yu-Cun Lin, Haimei Huang, and Yin-Chang Liu*, Induction of Oxidative DNA Damage by Flavonoids of Propolis: Its Mechanism and Implication about Antioxidant Capacity, Chem. Res. Toxicol. (2012) 25, 191-196.

3. Wang HJ, Huang HC, Chuang YC, Liao PJ, Yang DM, Yang WK, Huang H*, Modulation of tissue factor and thrombomodulin expression in human aortic endothelial cells incubated with high glucose. Acta Diabetol (2012) 49:125–130.

4. Huang-Joe Wang, M.D., Ph.D.; Te-Ling Lu, Ph.D.; Haimei Huang, Ph.D.; Huey-Chun, Paclitaxel induces thrombomodulin downregulation in human aortic endothelial cells. Texas Heart I nstitute Journal (2011) 38(1):20-6.

5. Mon-Juan Lee, Liu Chien-Liang, Ju-Ying Tsai, Wae-Ting Sue, Wan-Shun Hsia and Haimei Huang*, Identification and biochemical characterization of a unique Mn 2+ -dependent UMP kinase from Helicobacter pylori, Arch Microbiol (2010) 192:739–746.

6. Huang-Joe Wang, MD; Wan-Yu Lo , PhD; Te-Ling Lu, PhD; Haimei Huang* , PhD, (-) -Epigallocatechin-3-gallate Decreases Thrombin/Paclitaxel Induced Endothelial Tissue Factor Expression via inhibition of c-Jun Terminal NH2 Kinase Phosphorylation, Biochemical and Biophysical Research Communications (2010) 391: 716-721.

Recent Publications (From year 2004-2009)

7. Chan, K.W., Lee, Y.J., Wang, C.H., Huang, H.M. , and Sun, Y.J. Single-Stranded DNA-Binding Protein Complex from Helicobacter pylori Suggests an ssDNA-Binding Surface. J. Mol. Biol. (2009) 388 , 508-519.

8. Huang-Joe Wang, Haimei Huang , Yi-Ching Chuang and Huey-Chun Huang , Paclitaxel induces up-regulation of tissue factor in human aortic endothelial cells , International Immunopharmacology (2009) 9: 144-147.

9. Chu , C.-H., Lai, Y.-J., Huang, H., Sun, Y.-J. Kinetic and structural properties of triosephosphate isomerase from Helicobacter pylori. Proteins: Structure, Function, and Bioinformatics (2008) 71: 396-406

10. Huang-Joe Wang, Huey-Chun Huang, Yi-Ching Chuang and Haimei Huang*. Thrombin Induces the Expression of Tissue Factor in Human Aortic Endothelial Cells. Acta Cardiol Sin (2008) 24:151-6.

11. Mon-Juan Lee, Haimei Huang*, Wei Lin, Ray-Rong Yang, Chien-Liang Liu, Chung-Yu Huang. Activation of Helicobacter pylori inorganic pyrophosphatase and the importance of Cys16 in thermostability, enzyme activation and quaternary structure,   Archives of Microbiology (2007) 188 , 473-482.

12. Lu PK, Tsai JY, Chien HY, Huang H, Chu CH, Sun YJ. Crystal structure of Helicobacter pylori spermidine synthase: a Rossmann-like fold with a distinct active site, PROTEINS: Structure, Function, and Bioinformatics (2007) 67(3):743-54.

13. Chao, T.-C., Huang, H.-M., Tsai, J.-Y., Huang, C.-Y. and Sun, Y.-J. Crystal Structure of Inorganic Pyrophophatase from the Pathogenic Bacterium Helicobacter pylori, PROTEINS: Structure, Function, and Bioinformatics (2006) 65: 670–680.

14. Lee Mon-Juan, Liu Chien-Hung, Wang Sin-Yuan, Huang Chung-Ter and Huang Haimei*. Characterization of the Soj/Spo0J Chromosome Segregation Proteins and Identification of Putative parS Sequences in Helicobacter pylori, Biochemical and Biophysical Research Communications (2006) 342: 744-750.

15. Lee, Mon-Juan Lee, Huang, Chung-Yu, Sun, Yuh-Ju, Huang Haimei*. Cloning and characterization of spermidine synthase and its implication in polyamine biosynthesis in Helicobacter pylori strain 26695, Protein Expression and Purification (2005) 43:140-148.

16. Ho Cheng-En, Tseng Fan-Gang, Lin Shih-Chang, Su Chiun-Jie, Liu Zheng-Yan, Yu Ru-Ji, Chen Yu-Feng, Huang Haimei and Chieng Ching-Chang. Characterization of the surface tension and viscosity effects on the formation of nano-liter droplet arrays by an instant protein micro stamper. J. Micromech. Microeng. (2005) 15: 2317–2325.

17. Lyu, P.-K., Chien, S.-Y., Tsai, J.-Y., Fong, C.-T., Lee, M. J., Huang, H., Y.-J. Sun. Crystallization and Preliminary X-ray Diffraction Analysis of Spermidine Synthase from Helicobacter Pylori, Acta Crystallography (2004) D 60, 2067-2069.

18. Wu, Suh-Chin, Huang Haimei, Lin Chih-Chien. Expression and functional characterization of Helicobacter pyloricatalase from baculovirus-infected insect cells, Enzyme and Microbial Technology (2004) 35, 482–487.

19. Lin, S. C., Tseng, F. G., Huang, H. M., Chen, Yu-Feng, Tsai, Y. C., Ho, C. E. and Chieng, C. C. “Simultaneous Immobilization of Protein Microarrays by a Micro Stamper with Back-Filling Reservoir'”, Sensors and Actuators, B: Chemical, (2004) 99(1): 174-185.

20. Huang, H.*, Huang, S. Y., Chen, T. T., Chen, J. C., Chiou, C.L., Huang, T. M. Cisplatin restores p53 function and enhances the radiosensitivity in HPV16 E6 containing cells, Journal of Cellular Biochemistry (2004) 91, 756-765.

21. Book chapter
Fangang Tseng, Lin Shih-Chang Lin, Yao Da-Jen, Huang Haimei, and Chieng Ching-Chang (2004). “Technical Aspects of Protein Microarrays and Nanoarrays” in “Protein Microarrays” ISBN: 0-7637-3127-7, edited by Mark Schena, Jones and Bartlett Publishers (Sudbury, MA), Chapter 16, pp.305-338, 2004.

Publication List (1995-2003)

22. Tseng, F. G., Lin, S. C., Huang, H. M., Huang, C. Y. and Chieng, C. C. Protein Micro Arrays Immobilized By m-Stamps And Protein Wells On PhastgelR Pad. Sensors and Actuators B (2002) 83, 22-29.

23. Tseng Fan-Gang, Huang Chau-Yuh, Liu Chang-Sheng, Huang Haimei, and Chieng Ching-Chang. Size Effect on Surface Tension and Contact Angle between Protein Solution and Silicon Compound, PC and PMMA Substrates. Microscale Thermophysical Engineering (2002) 6: 31-53.

24. Chou Ruey-Hwang and Huang Haimei*. Activation of p53 tumor suppressor pathway in cervical carcinoma cells by sodium arsenite. Biochemical and Biophysical Research Communication (2002) 293, 298-306.

25. Sun NK, Kamarajan P, Huang H, and Chao CC. Restoration of UV sensitivity in UV-resistant HeLa cells by antisense-mediated depletion of damaged DNA-binding protein 2 (DDB2). FEBS Lett (2002) 512 : 168 -172.

26. Ruey-Hwang Chou and Huang  Haimei*. Sodium arsenite suppresses human papillomavirus 16 E6 gene and enhances apoptosis in E6-transfected human lymphoblastoid cells. Journal of Cellular Biochemistry (2002) 84: 615-624.

27.Tseng F. G., Huang H., Lin, S. C., Huang, Z. Y. and Chieng, C. C. 沾印式蛋白質微陣列晶片研製 [Protein microarrays Research], Instruments Today 科儀新知 ISSN 1019-5440 (2002) 23(5): 14-23.

28. Lin SC, Tseng FG, Huang HM, Huang CY, Chieng CC. Microsized 2D protein arrays immobilized by micro-stamps and micro-wells for disease diagnosis and drug screening.  Fresenius J Anal Chem. (2001) 371(2):202-8.

29. Huang, H.*, Liu , Y. C., Shyu, Y. J.  The Modulation studies of Arsenite induced Genotoxicity. Chinese Public Health J. (1999) 18(6):174-185.

30. Huang, H.*, S. C. Hsu, J. H. Shih, C. J. Kuo and I. D. Chiu Antimony trichloride induces DNA damage and apoptosis in mammalian cells. Toxicology (1998) 129: 113-123.

31. Wang, T. S., Y. F. Shu, Y. C. Liu, K. Y. Jan and H Huang*, Glutathione peroxidase and catalase modulate the genotoxicity of arsenite. Toxicology (1997) 121: 229-237. 

32. Liu, Y. C and Huang, H.*  The involvement of calcium-dependent protein kinase C in arsenite- induced genetoxicity in Chinese hamster ovary cells, J. of Cellular Biochemistry (1997) 64(3):423-433.

33. H. Huang, C. -Y. Li and J. B. Little Abrogation of P53 function by transfection of HPV16 E16 gene does not enhance resistance of human tumour cells to ionizing radiation.  Int. J. Radiation Biology  (1996) 70(2), 151-160. 

34. Wang, T. S., C. F. Kuo, K. Y. Jan, and H. Huang*. Arsenite induces Apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species. J. of  Cellular Physiology (1996) 169:256-268.

35. Liu, Y. C. and H. Huang*.  Lowering extracellular calcium content protects cells from arsenite-induced killing and micronuclei formation. Mutagenesis (1996) 11(1): 75-78.

Before 1995 (under construction)

36. Chao, C.C.K., T. C. Shieh and H.M. Huang. Use of a Monoclonal-Anibody to Detect DNA-Damage Caused by the Anti- cancer Drug cis-diamine- dichloroplatinum(II) in-Vivo and in-Vitro. FEBS LETTERS 354(1): 103-109, 1994.

37. Wang, T. S. and H. Huang*. Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells. Mutagenesis 9(3): 253-257, 1994.

38. Huang, H. C.F. Huang, D. R. Wu, C. M. Jinn and K. Y. Jan. Glutathione as a cellular defense against arsenite toxicity in cultured Chinese hmaster ovary cells. Toxicology 79: 195-204, 1993.

39. Huang, H. C.F. H. Huang, J. S. Huang, T. C. Wang and K. Y. Jan. The transition from late G1 to early S phase is most vulnerable to the coclastogenic effect of UV radiation plus arsenite. International Journal of Radiation Biology 61(1): 57-62, 1992.

40. Huang, H., S. H. Tyan and H. J. Huang. Effects of treatment with arsenite on the cytotoxicity of r-ray- irradiated Chinese hamster ovary cells and human fibroblasts. Bull. Inst. Zool., Academia Sinica, 31(4): 270-275, 1992.

41. Huang, H. , H. W. Chang, H. G. Hsieh and L. C. Tsai. Decrease of platinum accumulation in a cisplatin-resistant Chinese hamster ovary cell line. Bull. Inst. Zool., Academia Sinica, 31(3): 163-168, 1992.

42. Chao, C. C. K., S. L. Huang, H. Huang, and S. Lin-Chao. Cross resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA. Molecular and Cellular Biology 11(4): 2075-2080, 1991.

43. Yih, L. H., H. Huang, K. Y. Jan and T. C. Lee Sodium arsenite induces ATP depletion and mitochondrial damage in HeLa cells. Cell Biology International Reports 15(3): 253-264, 1991.

43. Tang, R. B., L. C. Tsai, H. M. Hwang, K. Hwang, K. G. W and M. W. Hung, The prevalence of allergic disease and IgE antibodies to house dust mite in schoolchildren in Taiwan . Clinical and Experimental Allergy 20: 33-38, 1990.

45, Huang, H., C. L. Peng and K. Y. Jan, Cell stage specificity of ultraviolet light and sodium arsenite on the induction of chromosome aberrations in book “Frontiers in Radiation Biology”, p.527-532 , edited by Emanuel Riklis, VCH, Balaban Publishers, 1990.

46. Lee Te-chang, Haimei Huang, and Kun-Yuan Jan. Resistant mechanism of an arsenic-resistant cell line. Nucl. Sci. J. 26(6) : 488-496, 1989 Dec.

47. Huang, Haimei. Lee, Te-Chang and Kun-Yuan Jan. Effects of posttreatment with arsenite on genetic toxicity of ultraviolet light and ionizing radiation, Nucl. Sci. J. 26(6) : 497-502, 1989 Dec.

 48. Lee, T. C., M. L. Wei, W. J. Chang, I. C. Ho, C. F. L., K.Y. Jan, and H. Huang . Elevation of Glutathione level and Glutathione S-transferase activity in arsenic-resistant Chinese hamster ovary cells. In Vitro Cellular and Developmental Biology 25 (5): 442-448, 1989.

49. Hubbard, K., H. Huang, M . F. Laspia, H. Ide, B. F. Erlanger and S. S. Wallace. Immunological Quantitation of thymine glycol in oxidized and X-irradiated DNA. Radiation Research 118, 257-268, 1989.

50. Huang, H. M ., C. L. Peng, T. C. Lee and K. Y. Jan. Cell-cycle dependence of the coclastogenicity of sodium arsenite. Bull. Inst. Zool. Academia Sinica 28(1): 49-53, 1989.

51. Huang, H. and S. S. Wallace. Immunological quantitation of thymine glycol in irradiated DNA. Nucl. Sci. J. 25(6) : 431-443, 1988.

52. Hayes, R. C., L. A. Petrullo, H. Huang, S. S. Wallace and J. E. LeClerc. Oxidative damage in DNA - Lack of mutageneicity by thymine glycol lesions. J. Mol. Biol. 201: 239-246, 1988.

53. Huang, H. , and W. R. Lee, Spermatid retains the highes level of ethylation in Drosophila testis after the treatment with ethyl methanesulfonate of diethylnitrosamine. Bull. Inst. Zool. Academia Sinica 26(4): 305-309, 1987.

54. Tsai, L. C., H. M. Chen, H. Huang, J. G. Li and I. J. Tsai. Purification of carcinoembryonic antigen (CEA) with monoclonal antibody. J. Asia Pacific Communication in Biochemistry (3): 333-337, 1987.

55. Huang, H. M. and C. B. Chae. Different RNA pattern on globin and non-globin 40S heterogeneous nuclear RNA-protein complexes in chicken reticulocyte nuclei. Nucleic Acid Research 11: 7057-7068, 1983.