Research

Cancer Metastasis

the spread of cancer cells to new areas of the body

    Cancer metastasis causes most cancer-associated mortality, yet it remains difficult to treat and renders cancer incurable. Metastasis is a sequence of multiple steps, including invasion from the primary tumor, intravasation, transport, extravasation, and colonization at distant organs. The need for tumor cell motility in the progression of metastasis has been established experimentally and is supported by clinical research. However, currently only few clinical interventions are designed to specifically target motility of tumor cell, and therapies specifically used to prevent cancer metastasis are severely limited. In an attempt to search for targets to treat cancer metastasis, the major focus of our research is to examine potential molecules that are involved in the regulation of tumor cell motility by using orthotopic xenograft mouse model. Our goal is to conduct research related to the translational medicine, especially in the field of cancer metastasis, cancer metabolism, and tumor micro-environment.

    癌症轉移的機制介紹可見我在科學發展月刊所撰寫之文章 連結

Project 1. Discover the hidden role of endogenous hydrogen sulfide in tumor metabolism

(Vav3/Cystathionine γ-Lyase /Hydrogen Sulfide (H2S)/PKM2/ Cancer Metabolism)

Project 2. The potential application of synthetic glucocorticoids (GCs) in cancer therapy

(MicroRNA-708/Ovarian cancer/Breast cancer/Melanoma/Metastasis)

    癌症細胞在缺氧時如何自救的機制可見我在科學發展月刊所撰寫之文章 連結