Publications (SCI)

Chen W.T. Chang H.K. Lin C.C. Yang S.M. Yin H.S.* (2017) Molecular Immunology 87, 308-316.  (Impact factor= 3.375)(NSC-2311-B-007-003-MY3)

 

Chen W. T. Huang W. Y. Chen T. Salawua E. O. Wang D. Lee Y. Z. Chang Y. Y. Yang L. W. Sue S. C. Wang X. Yin H. S.* (2016). Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity. Scientific Reports. 6, 27729 (Impact factor= 5.228, Journal ranking: 7/63,Q1)(NSC-2311-B-007-003-MY3)

You C. K. Wang C. J. Chew Y. Wang P.C. Yin H. S. Kao M. C. (2016). Functional characterization of Helicobacter pylori 26695 sedoheptulose 7-phosphate isomerase encoded by hp0857 and its association with lipopolysaccharide biosynthesis and adhesion. Biochemical and Biophysical Research Communications 477, 794-800.

Chen Y. C. Cheng C. S. Tjong S. C. Yin H. S.**Sue S. C.* (2014). A Case Study of Hydrogen Bonding in a Hydrophobic Cavity.  Journal of Physical Chemistry B. 118, 14602-14611.(**: co-corresponding author)(Impact factor= 3.187)

Chen W. T. Chen T. Cheng C. S. Huang W. Y. Wang X. Yin H. S.* (2014) Circular Permutation of Chicken Interleukin-1 Beta Enhances its Thermostability. Chemical Communications. 50(32), 4248-4250. (Impact factor= 6.567, Journal ranking: 21/163,Q1)  (*: corresponding author).(NSC-102-2627-B-007-003-)

Chen W. T. Wu Y. L. Chen T. Chang C. S. Chan H. J. Chou H. C. Chen C. Y. Yin H. S.* (2014) Proteomics Analysis of the DF-1 Chicken Fibroblasts Infected with Avian Reovirus Strain S1133. PLoS ONE  9,e92154 (Impact factor= 3.057, Journal ranking: 11/63,Q1)(NSC-102-2627-B-007-003-)

Wei H. Wang D. Qian Y. Liu X. Fan S. Yin H.S. Wang X. (2014) Structural basis for the specific recognition of IL-18 by its alpha receptor. FEBS Letters. 588, 3838-3843. Impact factor= 3.519 (Toward World-Class University Project,兩岸清華計畫)

Cheng C. S. Jia K. F. Chen T. Chang S. Y. Lin M. S. Yin H. S.* (2013) Experimentally validated novel inhibitors of Helicobacter pylori phosphopantetheine adenylyltransferase discovered by virtual high-throughput screening.PLoS ONE. 8(9): e74271. doi:10.1371/journal.pone.0074271 (Impact factor= 3.057, Journal ranking: 11/63,Q1)(*: corresponding author).(NSC-101-2627-B-007-003-)
 

Cheng C. S. Chen W. T. Chen Y. W. Chen C. H. Luo Y. H. Lyu P. C. Yin H. S.* (2012) Substitution of asparagine 76 by a tyrosine induces domain swapping in Helicobacter pylori phosphopantetheine adenylyltransferase. Journal of Biomolecular Structure and Dynamics. (In press, PMID: 22694317)(Impact factor= 2.30, Journal ranking: 38/72,Q3) (*: corresponding author).(NSC-99-2311-B-007-004-MY3)

Su B. S. Shen P. C. Hung L. H. Huang J. P. Yin H. S. Lee L. H. (2011) Potentiation of cell-mediated immune responses against recombinant HN protein of Newcastle disease virus by recombinant chicken IL-18. Veterinary Immunology and Immunopathology. 141, 283-292. ( Impact factor=1.535, Journal ranking: 29/133,Q1)

Cheng C. S. Chen C. H.  Luo Y. H. Chen W. T. Chang S. T. Lyu P. C. Kao M. C. Yin H. S.* (2011) Crystal structure and biophysical characterisation of Helicobacter pylori phosphopantetheine adenylyltransferase. Biochemical and Biophysical Research Communications. 408(2), 356-361.  (Impact factor=2.297)(*: corresponding author)(NSC-99-2311-B-007-004-MY3)

Cheng C. S. Chen W. T. Lee L. H. Chen Y. W. Chang S. Y. Lyu P. C. Yin H. S*. (2011) Structural and functional comparison of cytokine interleukin-1 beta from chicken and human. Molecular Immunology. 48, 947-955. (Impact factor= 2.973) (*: corresponding author).(NSC-99-2311-B-007-004-MY3)


Su B. S. Chiu H. H. Lin C. C. Shien J. H. Yin H. S*. Lee L. H.** (2011) Adjuvant activity of chicken interleukin-12 co-administered with infectious bursal disease virus recombinant VP2 antigen in chickens. Veterinary Immunology and Immunopathology. 139, 167-175. ( Impact factor=1.535, Journal ranking: 29/133,Q1)(*: corresponding author)

Cheng C. S. Lu W. S. Lyu P. C. Tu I. F. Yin H. S*.  (2011) Comparative analysis of receptor binding by chicken and human interleukin-1beta.  Journal of Molecular Modeling.  17(6), 1283-1294. (Impact factor=1.736, Journal ranking:34/102,Q2) (*: corresponding author)(NSC-96-2311-  B-007-015-MY3)

 

 

Su B. S. Yin H. S. Chiu H. H. Huang L. H. Huang J. P. Shien J. H. Lee L. H. (2011) Immunoadjuvant activities of a recombinant chicken IL-12 in chickens vaccinated with Newcastle disease virus recombinant HN protein. Veterinary Microbiology 151, 220-228. (Impact factor=2.511 Journal ranking: 6/133)

 

Chen Y. W. Chou H. C. Lyu P. C. Yin H. S. Huang F. L. Wayne Chang W. S. Fan C. Y. Tu I. F. Lai T. C. Lin S. T. Lu Y. C. Wu C. L. Huang S. H. Chan H. L. (2011) Mitochondrial proteomics analysis of tumorigenic and metastatic breast cancer markers. Functional & Integrative Genomics. 11, 225-239.

Sua B. S. Yin H. S. Shiena J. H. Chiuc H. H. Lee L. H. (2010) Production of biologically active chicken interleukin (IL) -12 and IL-18 synthesized by the recombinant fowlpox virus. Process Biochemistry 45, 1057-1064. (Impact factor=2.524, Journal ranking:28/133,Q1)

 Yang Z. J. Wang C. Y. Lee  L. H. Chuang K. P. Lien Y. Y. Yin H. S. Tong D. W. Xu X. G. Liu H. J.  (2010)  Development of ELISA kits for antibodies against against avian reovirus using the sigma C and sigma B proteins in the methyltropic yeast Pichia pastoris. J Virol Methods. 163, 169-174. (Impact factor=2.011)

 Wu Y. F. Shien J. H. Chiou S. H. Yin H. S.  Lee L. H.   (2008)   Structural and functional homology among chicken, duck, turkey and pigeon interleukin-8 proteins.  Vet Immunol Immunopathol.  125, 205-215.  (Impact factor=1.729,)

 Su Y. P. Shien J. H. Liu H. J. Yin H. S. Lee L. H.  (2007)  Avian reovirus core protein muA expressed in Eschechia coli possesses both NTPase and RTPase activities. J. Gen Virol. 88(Pt 6):1797-1805 (Impact factor=3.363)

 Connolly S. A. Leser G. P. Yin H. S.  Jardetzky T. S. Lamb R. A.  2006.  Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy.  Proc. Natl. Acad. Sci. USA. 103(47), 17903-17908.

Yin H. S. Wen X. Paterson R. G. Lamb R. A. Jardetzky T. S.  2006. Structure of the parainfluenza virus 5 F protein in its meyastable , pre-fusion conformation. Nature 439, 38-44.

Yin H. S. Paterson R. G. Wen X. Lamb R. A. Jardetzky T. S. 2005.  Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein. Proc. Natl. Acad. Sci. USA. 102(26), 9288-9293.

Yin H. S. Su Y. P. Lee  L. H.  2002.  Evidence of nucleotidyl phosphatase activity associated with core protein sigma A of avian reovirus S1133. Virology 293, 379-385.

Yin H. S. Lee L. H.  2000.  Characterization of avian reovirus non structural protein sigma NS synthesized in Escherichia coli. Virus Res. 67, 1-9.

Yin H. S. Shien H. K. Shien J. H. Lee L.H.  2000.  Synthesis in Escherichia coli of avian reovirus core protein sigma A and its dsRNA-binding activity. Virology 266, 33-41. 

Shien J. H. Yin H. S. Lee L.H.  2000.  An enzyme-linked immunosorbent assay for the detection of antibody to avian reovirus by using protein sigma B as the coating antigen. Res Vet Sci. 69, 107-112.

Yin H. S. Lee L. H.  1998.  Development and characterization of a nucleic acid probe for avian reoviruses. Avian Pathol 27, 423-426.  

Yin H. S.  Lee L. H.  1998.  Identification and characterization of RNA-binding activities of avian reovirus non-structural protein sigma NS. J. Gen. Virol. 79, 1411-1413.

Yin H. S. Shieh H. K. Lee L. H.  1997.  Characterization of the double-stranded RNA genome segment S3 of avian reovirus. Journal of Virol Methods 67, 93-101.

 

 Conference Proceedings

 

 

Yang S.M. Chen W.T. Yin H.S.* (2017, Sep). Structural and functional characteristics of wild-type Drosophila melanogaster glutamine synthetase II . 23nd Users' Meeting & Workshops, National Synchrotron Radiation Research Center, Hsinchu. MOST 103-2311-B-007-003-MY3.

 

Yang S.M. Chen W.T. Yin H.S.* (2017, May). Structural and catalytic characteristics of wild-type Drosophila melanogaster glutamine synthetase II and mutants . The 22th Biophysics Conference, Kaohsiung., Kaohsiung. MOST 103-2311-B-007-003-MY3.

 

Yin H.S*. (18, Oct, 2016). My thirty years with the life sciences. College of Veterinary Medicine. National Pingtung University of Science and Technology, Pingtung. MOST 103-2811-B-007-012. Yin HS is an invited speaker.

 

Chen W.T. Yin H.S*. (20-22, Sep, 2016). Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity. 22nd Users' Meeting & Workshops, National Synchrotron Radiation Research Center, Hsinchu, Taiwan. MOST 103-2311-B-007-003-MY3

 

Chen W. T. Yin H. S.* (19-21, May, 2016). Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity. The 21th Biophysics Conference, Hsinchu. MOST 103-2311-B-007-003-MY3. (Chen W. T. was selected as one of the five winners (general Biophysics) in the oral presentation and poster competition)

 

Wang Y. C. Yin H. S*. (19-21, May, 2016). Crystal structure and enzyme kinetics of Glutamine synthetase II in Drosophila melanogaster. The 21th Biophysics Conference, Hsinchu. MOST 103-2311-B-007-003-MY3. (Wang Y. C. was selected as one of the five winners (protein and nucleic acid) in the oral presentation and poster competition)

 

Chen T. Yin H. S*. (19-21, May, 2016). 3D modelling and molecular dynamics simulation of interleukin-1 signaling complex from chicken . The 21th Biophysics Conference, Hsinchu. MOST 103-2311-B-007-003-MY3.

 

Huang W. Y. Yin H. S*. (19-21, May, 2016). Biological analysis and application of IL-1 family. The 21th Biophysics Conference, Hsinchu. MOST 103-2311-B-007-003-MY3.

 

Yin H.S*. (15, Oct, 2015). Structure/ function relationship of chicken interleulin- 1 β. Department of Veterinary Medicine. National Chung Hsing University,Taichung. MOST 103-2811-B-007-012. Yin HS is an invited speaker.
 

Chen T. Chen W.T. Yin H.S*. (9-10, Sep, 2015). Investigation of the folding mechanism of domain swapping from Helicobacter pylori phosphopantetheine adenyltransferase. 21st Users' Meeting & Workshops, Hsinchu. MOST 103-2311-B-007-003-MY3.

 

Chen W.T. Yin H.S*. (9-10, Sep, 2015). The structural and functional impacts of hot spot residues in interleukin-1 β. 21st Users' Meeting & Workshops, Hsinchu. MOST 103-2811-B-007-012.

 

Chen W.T. Yin H.S*. (9-10, Sep, 2015). Crystallization and preliminary X-ray diffraction analysis of coenzyme A synthase from eukaryote. 21st Users' Meeting & Workshops, Hsinchu. MOST 103-2627-B-007-003.

 

Chen W. T. Jia K. F. Chen T. Lyu P. C. Yin H. S*. (Oct, 2014). Structural and kinetics analysis of substrate binding in the domain swapping form of phosphopantetheine adenylyltransferase from Helicobacter pylori. Twentieth Users’ Meeting. National Synchrotron Radiation Research Center, Hsinchu, Taiwan. MOST 102-2627-B-007-003.

 

Yin H.S*. (15, July, 2014). Structural/ function relationship, engineering , and application of chicken interleulin- 1 β. College of Life Science, Beijing University, Beijing. MOST 101-2627-B-007-003 Yin HS is an invited speaker.

 

Chen T, Cheng C. S, Yin H.S*. (2013, Oct). Circular permutation of chicken interleukin-1 beta enhances its thermostability. Nineteenth Users’ Meeting and Workshops. National Synchrotron Radiation Research Center, Hsinchu, Taiwan. MOST 101-2627-B-007-003.

 

Yin H.S.* (2012, Nov).  Phosphopantetheine adenyltransferase (PPAT) from Helicobacter pylori: kinetics, structural insights into mechanism of PPAT in CoA synthesis, discovery of the inhibitor against H. pylori infection. 2012 NHRU-NTHU Joint Research Conference, Zhunan, Taiwan. NSC 99-2311-B- 007-004-MY3. Yin HS is an invited speaker.

 

Wu Y.H. Hsieh C.C. Cheng C.C. Yin H.S*. 2012. Structural and kinetics analysis of substrate binding to the phosphopantetheine adenylyltransferase and its mutants from Helicobacter pylori. Eighteenth Users’ Meeting and Workshops. National Synchrotron Radiation Research Center. August 29-30, 2012. Hsinchu, Taiwan. (* corresponding author) ISSN 1815-0098 (Wu Y. H. was selected as one of the seven winners (interdisciplinary life science) in the oral presentation and poster competition) (NSC-99-2311-B-007-004-MY3)

 

Chen W.T. Cheng C.S. Yin H.S.* 2011. Substitution of asparagine 76 by a tyrosine induces domain swapping in Helicobacter pylori phosphopantetheine adenylyltransferase Seventeenth Users’ Meeting. National Synchrotron Radiation Research Center. October 19-21, 2011. Hsinchu, Taiwan. (* corresponding author) ISSN 1815-0098 (Chen W. T. was selected as one of the five winners (interdisciplinary life science) in the oral presentation and poster competition) (NSC-99-2311-B-007-004-MY3)

 

Chen W.T. Lee L.H. Yin H.S.* 2011. Adjuvant activity of chicken interleukin-12 co-admininistrated with infectious bursal disease virus recombinant VP2 antigen in chickens. 5th Vaccine and ISV, annual global congress P3.3.10. Seattle, USA.

 

 

Chen W. T. Yin H. S.* 2011. Cytokine adjuvant, recombinant chicken interleukin-18 constructed exhibits bioactivity. 5th Vaccine and ISV, annual global congress P3.3.9. Seattle, USA.

 

Chen W. T. Luo Y. H. Chen C. H. Cheng C. S. Chang S. Y. Yin H. S.* 2010. Structural and functional studies of Helicobacter pylori wild-type and mutated proteins phosphopantetheine adenylytransferase. Sixteenth Users’ Meeting. National Synchrotron Radiation Research Center. 2010, October 20-22, Book of abstracts, P153. Hsinchu, Taiwan. (* corresponding author) ISSN 1815-0098 (Chen W. T. was selected as one of the five winners (interdisciplinary life science) in the oral presentation and poster competition) (NSC-99-2311-B-007-004-MY3)

Lu W. S. Tu I. F. Cheng C. S. Yin H. S.* 2010. High-resolution crystal structure of chicken interleukin-1β reveals differences in receptor binding compared to human interleukin-1β. The 15th joint biophysics conference. 2010, May 19-21, Book of abstract, P106. Academia Sinica, Taiwan.  (* corresponding author)(NSC-99-2311-B-007-004-MY3)


Lu W. S. Cheng C. S. Lyu P. C. Lee L. H. Wang W. C. Yin H. S.*   2009.  Crystal structure of chicken interleukin-1 beta. Fifteenth Users’ Meeting. National Synchrotron Radiation Research Center. 2009, October 15-16, Book of abstracts, P172. Hsinchu, Taiwan. (* corresponding author) ISSN 1815-0098
(Lu W. S. was selected as one of the five winners (interdisciplinary life science) in the oral presentation and poster competition) (NSC-96-2311-B-007-015-MY3)

 

Chen C. H. Cheng C. S. Lyu P. C. Kao M. C. Wang W. C. Yin H. S.*  2009.  Crystal structure of phosphopantetheine adenyltransferase from Helicobacter pylori.  Fifteenth Users’ Meeting. National Synchrotron Radiation Research Center. 2009, October 15-16, Book of abstracts, P146. Hsinchu, Taiwan. (* corresponding author) ISSN 1815-0098 (NSC-96-2311-B-007-015-MY3)

 

Yin H. S. Paterson R.G. Lamb R.A. Jardetzky T. S.  2005.  Expression, purification and characterization of a soluble form of the parainfluenza virus type 3 fusion protein. 24th Annual Meeting of American Society for Virology. 2005, June 18-22, Book of abstracts, W51-2. Pennsylvania, USA.

 

Yin H. S. Lamb R.A.  Jardetzky T. S.  2005.  Structure of the paramyxovirus fusion protein: implications for membrane fusion. Northwestern University BMBCB 2005 Scientific Retreat. 2005, April 14-15, Illinois, USA.

 

Yin H. S. Lee L. H.  2000.  Characterization of nucleotidyl phosphatase activity of avian reovirus core protein sigma A. The Joint Meeting of the Chinese Association of Veterinary Science and the Taiwan Association of Veterinary Medicine and Animal Husbandry. 2000 May, Book of abstracts, p34, Chiayi, Taiwan.

 

Yin H. S. Shieh H. K. Shien J. H. Lee L. H.  1998.  Gene cloning, expression and characterization of avian reovirus core protein sigma A. The Joint Meeting of the Chinese Association of Veterinary Science and the Taiwan Association of Veterinary Medicine and Animal Husbandry. 1998 December, Book of abstracts, p36, Taipei, Taiwan.

 

Yin H. S. Shieh H. K. Lee L. H.  1995.  Cloning, sequencing and expression of the S3 gene of avian reovirus. The Joint Meeting of the Chinese Association of Veterinary Science and the Taiwan Association of Veterinary Medicine and Animal Husbandry, Taichung, Taiwan.