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Original Research Papers

1. Chen, H.-H., Hsu, C.-H., Chang, Y.-C. and Wei, H.-H. (1981) Mossbauer spectroscopic studies of trifluorostannate (ll) in frozen aqueous solutions. Radiochem. Radioanal. Letters 59, 167-171.

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2. Scott, R.D., Chang, Y-C., Graves, D.J. and Metzler, D.E. (1983) NMR study of 5-fluoro-pyridoxal phosphate-containing cytosolic aspartate aminotransferase, in ¡§Chemical and biochemical aspects of vitamin B6 catalysis¡¨, vol. 2, R.Alan ed., Liss Inc., New York,pp.249-257.

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3. Graves, D.J., Soman, G., Hurst, M. and Chang, Y.-C. (1983) Involvement of guanidinogroup in anion-binding sites and in enzyme-catalyzed covalent modification reactions, Current Topics in Cellular Regulation 24, 181-190.

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4. Chang, Y,-C., McCalmont, T. and Graves, D.J. (1983) Functions of 5¡¥-phosphate group of pyridoxal 5¡¦-phosphate in phosphorylase: A study using pyridoxal reconstituted enzyme as a model system. Biochemistry 22, 4987-4993.

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5. Soman, G., Chang, Y.-C. and Graves, D.J. (1983) Effects of oxyanions of early transition metals on rabbit skeletal muscle phosphorylase. Biochemistry 22, 4993-4998.

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6. Arus, C., Chang, Y.-C. and Barany, M. (1985) N-acetylaspartate as an intrinsic thermometer for H-1 NMR of sliced brain.  J. Magn.Reson. 63, 376-379.

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7. Barany, M., Chang, Y-C., Arus, C., Rustan, T. and Frey. W.H. (1985) Increased glycerol-3-phosphocholine in postmortem Alzheimer¡¥s brain.  Lacet I, 517.

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8. Barany, M., Chang, Y.-C. and Arus, C. (1985) Effects of halothane on the natural abundance C-13 NMR spectra of excised rat brain.  Biochemistry 24, 7911-7917.

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9. Barany, M., Arus, C. and Chang, Y.-C. (1985) Natural abundance C-13 NMR of brain. Magn. Reson. Med.  2, 289-295.

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10. Arus, C., Chang, Y.-C. and Barany, M. (1985) The separation of phosphocreatine from creatine and pH determination in frog muscle by natural abundance C-13 NMR. Biochem. Biophys. Acta.  844, 91-93.

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11. Chang, Y.-C., Arus, C. and Barany, M. (1985) Characterization of the broad resonance in P-31 NMR spectra of excised rat brain.  Physiol. Chem. Phys. Med. NMR 17, 143-154.

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12. Scott, R.D., Chang, Y.-C., Graves, D.J. and Metzler, D.E. (1985) Studies of 6-fluoropyridoxal and 6-fluoropyridoxamine 5¡¥-phosphate in cytosolic aspartate aminotransferase. Biochemistry 24, 7668-7681.

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13. Chang, Y.-C. and Graves, D.J. (1985) Use of 6-fluoroderivatives of pyridoxal phosphate in the study of coenzyme function in glycogen phosphorylase.  J. Biol. Chem. 260, 2709-2714.

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14. Chang, Y.-C., Scott, R.D. and Graves, D.J. (1986) Function of pyridoxal-5¡¥-phosphate in glycogen phosphorylase: F-19 NMR and kinetic studies of phosphorylase reconstituted with 6-fluoropyridoxal and 6-fluoropyridoxal phosphate.  Biochemistry 25, 1932-1939.

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15. Gottlieb, D.I., Chang, Y.-C. and Schwob, J. (1986) Monoclonal antibodies of glutamic acid decarboxylase.  Proc, Natl. Acad. Sci. USA 83, 8808-8812.

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16. Chang, Y.-C., Soman, G. and Graves, D.J. (1987) Identification of an enzymatic activity that hydrolyzes protein bound ADP-ribose in skeletal muscle.  Biochem. Biophys. Res. Comm. 139, 932-939.

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17. Chang, Y.-C., Scott R.D. and Graves, D.J. (1987) Function of pyridoxal-5¡¥-phosphate in glycogen phosphorylase: A model study using 6-fluoro-5¡¦-deoxypyridoxal and 5¡¥-deoxypyridoxal reconstituted enzyme.  Biochemistry 26, 360-367.

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18. Chang, Y.-C. and Gottlieb, D.I. (1988) Characterization of the protein purified with monoclonal antibodies to glutamic acid decarboxylase.  J. Neurosci. 8, 2123-2130.

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19. Hon, Y.-S., Chang, Y.-C. and Gong, M.-L. (1990) Efficient enantioselective syntheses of (4R)-substituted (2S)-glutamic acids.  Heterocycles 31, 191-196.

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20. Chang, Y.-C., Hon, Y.-S. and Chow, W.-Y. (1990) Solubilization and characterization of glutamate binding sites from porcine brain.  Neurochem. Int. 16, 173-185.

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21. Hon, Y.-S., Chang, Y.-C. and Gong, M.-L. (1991) The studies of a-alkylation of N-tert-BOC-5(S)-tert-butyldimethylxymethyl-2-pyrrolidinones. Bull. Inst. Chem. Academia Sinica.  38, 23031.

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22. Chang, Y.-C., Lin, I.-H., Lee, Y.-H. and Leng, C.-H. (1991) Solubilization, characterization and partial purification of AMPA, quisqualate, kainate-sensitive L-[3H]glutamate binding sites from porcine brain synaptic junctions.  J. Neurochem. 57, 1921-1926.

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23. Tong, C.-K., Pang, M.-P. and Chang, Y.-C. (1992) Characterization of L-glutamate and kainate binding sites of the brain of a freshwater fish Telapilia monsanbica. Neuroscience 49, 237-246.

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24. Chang, Y.-C. (1992) Efficient precipitation and accurate quantitation of detergent-solubilized membrane proteins.  Anal. Biochem. 205, 22-26.

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25. Chang, Y.-C., Hon, Y.-S., Chow, W.-Y., Lin, T.-A., Jan, P.-Y. and Wang, C.-M. (1993) Study of stereoselectivity of L-glutamate receptors by synthetic 4(R)-and 4(S)-substituted L-glutamate analogues.  Brain Res. 604, 86-89.

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26. Chang, Y.-C., Chiu, S.-J. and Kao, K.-P. (1993) Beta-N-methylamino-L-alanine induces behavioral changes and a decrease of glutamate receptors.  Chinese J. Physiol. 36, 79-84.

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27. Wu, T.-Y. and Chang, Y.-C. (1994) Hydrodynamic and pharmacological characterization of putative AMPA/kainate-sensitive L-glutamate receptors solubilized from porcine brain.  Biochem. J. 300, 365-371.

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28. Tyan, S.-H., Chang, S.-M., Gean, P.-W., Hon, Y.-S. and Chang, Y.-C. (1996) 4(R)- and 4(S)- (5-phenylpentyl)-glutamic acids attenuate excitatory postsynaptic potential on hippocampus without inhibiting postsynaptic NMDA and AMPA receptors.  Chinese J. Physiol. 39, 131-137.

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29. Chang, Y.-C., Wu, T.-Y., Li, B.-F., Gao, L.-H., Liu, C.-Y. and Wu, C.-L. (1996) Purification and biochemical characterization of AMPA/kainate-sensitive L-glutamate receptors of porcine brain.  Biochem. J. 319, 49-57.

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30. Wu, T.-Y., Liu, C.-Y. and Chang, Y.-C. (1996) A study of the oligomeric state of AMPA-preferring glutamate receptors in the synaptic junctions of porcine brain.  Biochem. J. 319, 331-339.

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31. Tyan, S.-H., Sue, T.-Y., Hon, Y.-S., Gean, P.-W. and Chang, Y.-C. (1997) A novel NMDA receptor antagonist protects against N-methyl-D-aspartate- and glutamate-induced neurotoxicity in the goldfish retina.  Eur. J. Pharmacol. 321, 171-179.

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32. Lai, S.-L., Ling, S.-C., Kuo, L.-H., Shu, Y.-C., Chow, W.-Y. and Chang, Y.-C. (1998)  Characterization of granular particles isolated from postsynaptic densities.  J. Neurochem. 71, 1694-1701.

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33. Chang, S.-M., Wu, Y.-M., Chang, Y.-C., Hsu, Y.-C., Hsu, H.Y., Chen, C.-C. and Chow, W.-Y. (1998)  Molecular and electrophysiological characterization of fGluR3, an ionotropic glutamate receptor subunit of a teleost fish.  Mol. Brain Res. 57, 211-220.

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34. Lai, S.-L., Chiang, S.-F., Chen, I.-T., Chow, W.-Y. and Chang, Y.-C. (1999) Inter-protein disulfide bonds formed during isolation process tighten the structure of the postsynaptic density.  J. Neurochem.73, 2130-2138.

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35. Hon, Y.S., Chang, Y.-C. and Chu, K.P. (2000)  Synthesis of 3-substituted ¡VL-glutamic acid analogues for neuroexcitatory activity studies.  J. Chinese Chem. Soc. 47, 91-102.

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36. Sui, C.-W., Chow, W.-Y. and Chang, Y.-C. (2000) Effects of disulfide bonds formed during isolation process on the structure of the postsynaptic density.  Brain Res. 873, 268-273.

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37. Lin, Y.-C., Huang, Z.-H., Jan, I.S., Yeh, C.-C., Wu, H.-J., Chou, Y.C. and Chang, Y.-C. (2002) Development of excitatory synapses in cultured neurons dissociated from the cortices of rat embryos and rat pups at birth. J. Neurosci. Res. 67, 484-493.

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38. Jan, H.-H., Chen, I.-T., Tsai, Y.-Y. and Chang, Y.-C. (2002) Structural roles of the zinc ions bound to the postsynaptic density. J. Neurochem. 83, 525-534.

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39. Srisalam, S., Wang, H.-M., Kumar, T.K.S., Rajalingam, D., Sivaraja, V., Sheu, H.-S., Chang, Y.-C. and Yu, C. (2002) Amyloid-like fibril formation in an all b-barrel protein involves the formation of partially structured intermediate(s). J. Biol. Chem. 277, 19027-19036.(SCI)

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40. Huang, Z.-H., Wu, H.-J., Yeh, C.-C., Huang, R.-H., Chou, Y.-C. and Chang, Y.-C. (2006) Dendritic spines of developing rat cortical neurons in culture. Chinese J. Physiol.49,39-45.(SCI)

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41.Szu-Heng Liu, Huei-Hsuan Cheng, San-Yuan Huang, Pei-Chun Yiu and Yen-Chung Chang  (2006) Studying the protein organization of the postsynaptic density by a novel solid-phase- and chemical crosslinking-based technology, Molecular and Cellular Proteomics, 5:1019-1032.(SCI)

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42. Huei-Hsuan Cheng, Szu-Heng Liu, Hui-Cheng Lee, Ya-Shiuan Lin, Zu-Han Huang, Cheng-I Hsu, Yu-Che-Chen and Yen-Chung Chang (2006) The heavy chain of cytoplasmic dynein is a major protein component of the postsynaptic density fraction. Journal of Neuroscience Research, 84:244-254.(SCI)

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43. Li-Ping Liu, Szu-Hen Liu and Yen-Chung Chang  (2007) Assembling microtubules diintegrate the postsynaptic density in vitro, Cell Motility and Cytoskeleton. 64:6-18.(SCI)

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44.Tzeng, D.-W., Lin, M.-H., Chen, B.-Y., Chen, Y.-C., Chang, Y.-C., and Chow, W.-Y.  Molecular and functional studies of tilapia (Oreochromis mossambicus) NMDA receptor NR1 subunits. Comp. Biochem. Physiol. In press.

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45.Huan-Chang Zeng, Yi-Cheng Ho, Shih-Ta Chen, Hsi-Wen Tung, Wei-Leun Fang and Yen-Chung Chang (2007) Studying the formation of large cell aggregates in patterned neuronal cultures, J. Neurosci. Methods, 165:72-82.

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46.Chia-Wei Chang, Sheng-Chih Peng, Wen-Yao Cheng, Szu-Heng Liu, Huei-Hsuan Cheng, San-Yuan Huang and Yen-Chung Chang (2007)  Studying the protein-protein interactions in the postsynaptic density by immunoabsorption and chemical crosslinking means. Proteomics, in press. (SCI)

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47.Zu-Han Huang, Huei-Hsuan Cheng, Huei-In Wu, Fourier H. Tzeng and Yen-Chung Chang (2007) ¡§Studying the temperature-dependent events of live cells under confocal and epi-fluorescence microscopy by a solid-state heating/cooling system¡¨ in ¡§Modern Research and Education Topics in Microscopy¡¨ 2007.

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48. Wei-Cheng Horng, Yuan-Hun Yen and Yen-Chung Chang (2008) A novel solid phase- and chemical crosslinking-based technology for determining protein localization in biological supramolecules, Proteomics 8:4642-4646. (SCI, IF: 5.1)

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49. Huei-Hsuan Cheng, Zu-Han Huang, Wei-Hsiang Lin, Wei-Yuan Chow and Yen-Chung Chang_ (2009) Cold-induced exodus of postsynaptic density proteins from dendritic spines. Journal of Neuroscience Research,87:460-469. (SCI, IF: 3.3)
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50. Wen-Yao Cheng, Wei-Lun Hsu, Hui-Hsuan Cheng, Zu-Han Huang and Yen-Chung Chang  (2009) An observation chamber for studying
temperature-dependent and drug-induced events in live neurons using fluorscence microscopy. Analytical Biochemistry 386:105-112. (SCI, IF:3.0)

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51. Shih-Rung Yeh, Yung-Chan Chen , Huan-Chieh Su , Tri-Rung Yew , Hsiu-Hua Kao, Yu-Tao Lee , Tai-An Liu , Hsieh Chen , Yen-Chung Chang , Pin Chang , Hsin Chen (2009). Recording and stimulating of neuronal activity using carbon-nanotube probes. /Langmuir /23:7718-7724. (SCI, IF: 4.00)

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52. C.-W. Lin, Y.-T. Lee, C.-W. Chang, W.-L. Hsu, _Y.-C. Chang _and W.Fang (2009) Novel Glass Microprobe Arrays for Neural Recording, Biosensors and Bioelectronics, in press. (SCI, IF: 5.1)

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53. Chen WS, Chang YC, Chen YJ, Teng CY, Wang CH, Wu TY (2009) Development of a prokaryotic-like polycistronic baculovirus expression vector by the linkage of two internal ribosome entry sites J. Virol. Methods 159: 152-159 (SCI, IF: 2.0)

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54. Cheng-I Hsu, Tzu-Chien Wang, Szu-Yu T. Hou, Ting-Yu Chin and Yen-Chung Chang  (2009) A quantitative study of the developmental changes in calcium-permeable AMPA receptor-expression neurons in the rat somatosensory cortex. J. Comparative Neurology, in press. (SCI, IF: 3.8)

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55. Huan-Chieh Su, Chang-Hsiao Chen, Yung-Chan Chen, Da-Jeng Yao, Hsin Chen, Yen-Chung Chang, Tri-Rung Yew (2009) Improving the adhesion of carbon nanotubes to a substrate using microwave treatment. Carbon, DOI: 10.1016/j.carbon.2009.10.032 (SCI, IF: 4.3)

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56. Huei-Ing Wu, Gia-Her Cheng, Yi-Yun Wong, Wei-Yuan Chow, Wei-Lun Fang and Yen-Chung Chang ¡§A lab-on-a-chip platform for studying the subcellular functional proteome of neuronal axons¡¨, Lab on a Chip, DOI:10.1039/B918217A. (SCI, IF: 6.5)

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57. Y.-T. Lee, C.-W. Lin, C.-M. Lin, S.-R. Yeh, _Y.-C. Chang,_ and W. Fang, 2009, ¡§A Pseudo-3D Glass Microprobe Array: Glass Microprobe with Embedded Silicon for Alignment and Electrical Interconnection During Assembly,¡¨ Journal of Micromechanics and Microengineering, in press.

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