4_3

BLASTP 2.2.1 [Apr-13-2001]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

RID: 1006584924-19351-29342

Query= (756 letters)

Database: nr 799,241 sequences; 254,026,857 total letters

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

gi|13878583|sp|Q9JK91|MLH1_MOUSE  DNA MISMATCH REPAIR PROTEI...  1292  0.0
gi|13591989|ref|NP_112315.1|  (NM_031053) mismatch repair pr...  1289  0.0
gi|4557757|ref|NP_000240.1|  (NM_000249) mutL homolog 1; mut...  1467  0.0
gi|466462|gb|AAA17374.1|  (U07418) human homolog of E. coli ...  1466  0.0
gi|604369|gb|AAA85687.1|  (U17857) hMLH1 gene product [Homo ...  1453  0.0
gi|12835158|dbj|BAB23172.1|  (AK004105) putative [Mus musculus]   753  0.0
gi|13543339|gb|AAH05833.1|AAH05833  (BC005833) Similar to mu...   731  0.0
gi|7304079|gb|AAF59117.1|  (AE003838) Mlh1 gene product [Dro...   615  e-175
gi|3192877|gb|AAC19117.1|  (AF068257) mutL homolog [Drosophi...   608  e-173
gi|460627|gb|AAA16835.1|  (U07187) Mlh1p [Saccharomyces cere...   471  e-132

Alignments

>gi|13878583|sp|Q9JK91|MLH1_MOUSE DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1)
 gi|7595954|gb|AAF64514.1|AF250844_1 (AF250844) MutL homolog 1 protein [Mus musculus]
          Length = 760

 Score = 1292 bits (3344), Expect = 0.0
 Identities = 651/760 (85%), Positives = 693/760 (90%), Gaps = 4/760 (0%)

Query: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
           M+FVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKST+IQV+VKEGGLKLIQ
Sbjct: 1   MAFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVVVKEGGLKLIQ 60

Query: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
           IQDNGTGIRKEDLDIVCERFTTSKLQ+FEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61  IQDNGTGIRKEDLDIVCERFTTSKLQTFEDLASISTYGFRGEALASISHVAHVTITTKTA 120

Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
           DGKCAYRASYSDGKL+APPKPCAGNQGT ITVEDLFYNI TRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRRKALKNPSEEYGKILEVV 180

Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
           GRYS+HN+GISFSVKKQGETV+DVRTLPNA+TVDNIRSIFGNAVSRELIE+GCEDKTLAF
Sbjct: 181 GRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELIEVGCEDKTLAF 240

Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
           KMNGYISNANYSVKKCIFLLFINHRLVES +LRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESAALRKAIETVYAAYLPKNTHPFLYLSLEISP 300

Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
           QNVDVNVHPTKHEVHFLHEESIL+RVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGE  
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILQRVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEAA 360

Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQ--AIVTEDKTD 418
           +              DKVYA+QMVRTDSR+QKLDAFLQP+S  + SQPQ  A V   +T+
Sbjct: 361 RPTTGVASSSTSGSGDKVYAYQMVRTDSRDQKLDAFLQPVSSLVPSQPQDPAPVRGARTE 420

Query: 419 ISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSS--NPRKRHRXX 476
            S  RA ++DEEML LPAPAE AA++++LE ++   TS+ ++K  PTSS  + RKRHR  
Sbjct: 421 GSPERATREDEEMLALPAPAEAAAESENLERESLMETSDAAQKAAPTSSPGSSRKRHRED 480

Query: 477 XXXXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNP 536
                      KEMTAAC PRRRIINLTSVLSLQEEI+E+ HE LRE+L NHSFVGCVNP
Sbjct: 481 SDVEMVENASGKEMTAACYPRRRIINLTSVLSLQEEISERCHETLREILRNHSFVGCVNP 540

Query: 537 QWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESG 596
           QWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESG
Sbjct: 541 QWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESG 600

Query: 597 WTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIF 656
           WTE+DGPKEGLAEYIVEFLKKKAEMLADYFS+EIDEEGNLIGLPLLID+YVPPLEGLPIF
Sbjct: 601 WTEDDGPKEGLAEYIVEFLKKKAEMLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIF 660

Query: 657 ILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTV 716
           ILRLATEVNWDEEKECFESLSKECAMFYSIRKQYI EESTLSGQQS++PGS    WKWTV
Sbjct: 661 ILRLATEVNWDEEKECFESLSKECAMFYSIRKQYILEESTLSGQQSDMPGSTSKPWKWTV 720

Query: 717 EHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
           EHI+YKA RSH+LPPKHFTEDGN+LQLANLPDLYKVFERC
Sbjct: 721 EHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLYKVFERC 760

>gi|13591989|ref|NP_112315.1| (NM_031053) mismatch repair protein [Rattus norvegicus]
 gi|13878571|sp|P97679|MLH1_RAT DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1)
 gi|1724118|gb|AAB38506.1| (U80054) mismatch repair protein [Rattus norvegicus]
          Length = 757

 Score = 1289 bits (3336), Expect = 0.0
 Identities = 639/758 (84%), Positives = 684/758 (89%), Gaps = 3/758 (0%)

Query: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
           MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEM ENCLDAKST+IQVIV+EGGLKLIQ
Sbjct: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMTENCLDAKSTNIQVIVREGGLKLIQ 60

Query: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
           IQDNGTGIRKEDLDIVCERFTTSKLQ+FEDLA ISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61  IQDNGTGIRKEDLDIVCERFTTSKLQTFEDLAMISTYGFRGEALASISHVAHVTITTKTA 120

Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
           DGKCAYRASYSDGKL+APPKPCAGNQGT ITVEDLFYNI TR+KALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRKKALKNPSEEYGKILEVV 180

Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
           GRYS+HN+GISFSVKKQGETV+DVRTLPNA+TVDNIRSIFGNAVSRELIE+GCEDKTLAF
Sbjct: 181 GRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELIEVGCEDKTLAF 240

Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
           KMNGYISNANYSVKKCIFLLFINHRLVES +L+KAIE VYAAYLPKNTHPFLYL LEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESAALKKAIEAVYAAYLPKNTHPFLYLILEISP 300

Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
           QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGE V
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEAV 360

Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
           K              DKV+A+QMVRTDSR+QKLDAF+QP+S+ L SQPQ  V  ++T+ S
Sbjct: 361 KSTTGIASSSTSGSGDKVHAYQMVRTDSRDQKLDAFMQPVSRRLPSQPQDPVPGNRTEGS 420

Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSE-MSEKRGPTS-SNPRKRHRXXXX 478
             +A Q+D+E+ ELPAP E AA + SLE ++  G SE ++ +R P+S  + RKRH     
Sbjct: 421 PEKAMQKDQEISELPAPMEAAADSASLERESVIGASEVVAPQRHPSSPGSSRKRHPEDSD 480

Query: 479 XXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQW 538
                   RKEMTAAC PRRRIINLTSVLSLQEEIN++GHE LREML NH+FVGCVNPQW
Sbjct: 481 VEMMENDSRKEMTAACYPRRRIINLTSVLSLQEEINDRGHETLREMLRNHTFVGCVNPQW 540

Query: 539 ALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWT 598
           ALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRL EPAPLFD AMLALDSPESGWT
Sbjct: 541 ALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLPEPAPLFDFAMLALDSPESGWT 600

Query: 599 EEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFIL 658
           EEDGPKEGLAEYIVEFLKKKA+MLADYFS+EIDEEGNLIGLPLLID+YVPPLEGLPIFIL
Sbjct: 601 EEDGPKEGLAEYIVEFLKKKAKMLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIFIL 660

Query: 659 RLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEH 718
           RLATEVNWDEE ECFESLSKECA+FYSIRKQYI EES LSGQQS++PGS    WKWTVEH
Sbjct: 661 RLATEVNWDEE-ECFESLSKECAVFYSIRKQYILEESALSGQQSDMPGSPSKPWKWTVEH 719

Query: 719 IVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
           I+YKA RSH+LPPKHFTEDGN+LQLANLPDL KVFERC
Sbjct: 720 IIYKAFRSHLLPPKHFTEDGNVLQLANLPDLCKVFERC 757

>gi|4557757|ref|NP_000240.1| (NM_000249) mutL homolog 1; mutL (E. coli) homolog 1 [Homo sapiens]
 gi|14725771|ref|XP_044891.1| (XM_044891) mutL homolog 1 [Homo sapiens]
 gi|730028|sp|P40692|MLH1_HUMAN DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1)
 gi|631299|pir||S43085 DNA mismatch repair protein MLH1 - human
 gi|463989|gb|AAC50285.1| (U07343) hMLH1 [Homo sapiens]
 gi|1079787|gb|AAA82079.1| (U40978) DNA mismatch repair protein homolog [Homo sapiens]
 gi|13905126|gb|AAH06850.1|AAH06850 (BC006850) mutL (E. coli) homolog 1 (colon cancer, nonpolyposis
           type 2) [Homo sapiens]
 gi|741682|prf||2007430A DNA mismatch repair protein [Homo sapiens]
          Length = 756

 Score = 1467 bits (3797), Expect = 0.0
 Identities = 730/756 (96%), Positives = 730/756 (96%)

Query: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
           MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
Sbjct: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60

Query: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
           IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120

Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
           DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180

Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
           GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF
Sbjct: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240

Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
           KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300

Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
           QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360

Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
           K              DKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS
Sbjct: 361 KSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420

Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXX 480
           SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR      
Sbjct: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVE 480

Query: 481 XXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
                 RKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL
Sbjct: 481 MVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540

Query: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
           AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE
Sbjct: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600

Query: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
           DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL
Sbjct: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660

Query: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
           ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV
Sbjct: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720

Query: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
           YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Sbjct: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756

>gi|466462|gb|AAA17374.1| (U07418) human homolog of E. coli mutL gene product, Swiss-Prot
           Accession Number P23367 [Homo sapiens]
          Length = 756

 Score = 1466 bits (3796), Expect = 0.0
 Identities = 729/756 (96%), Positives = 730/756 (96%)

Query: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
           MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
Sbjct: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60

Query: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
           IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120

Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
           DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180

Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
           GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRS+FGNAVSRELIEIGCEDKTLAF
Sbjct: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSVFGNAVSRELIEIGCEDKTLAF 240

Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
           KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300

Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
           QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360

Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
           K              DKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS
Sbjct: 361 KSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420

Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXX 480
           SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR      
Sbjct: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVE 480

Query: 481 XXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
                 RKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL
Sbjct: 481 MVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540

Query: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
           AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE
Sbjct: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600

Query: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
           DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL
Sbjct: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660

Query: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
           ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV
Sbjct: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720

Query: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
           YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Sbjct: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756

>gi|604369|gb|AAA85687.1| (U17857) hMLH1 gene product [Homo sapiens]
          Length = 752

 Score = 1453 bits (3761), Expect = 0.0
 Identities = 726/756 (96%), Positives = 726/756 (96%), Gaps = 4/756 (0%)

Query: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
           MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
Sbjct: 1   MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60

Query: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
           IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61  IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120

Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
           DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180

Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
           GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF
Sbjct: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240

Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
           KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300

Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
           QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360

Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
           K              DKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS
Sbjct: 361 KSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420

Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXX 480
           SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR      
Sbjct: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVE 480

Query: 481 XXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
                 RKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL
Sbjct: 481 MVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540

Query: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
           AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE
Sbjct: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600

Query: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
           DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL
Sbjct: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660

Query: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
           ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPG    SWKWTVEHIV
Sbjct: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPG----SWKWTVEHIV 716

Query: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
           YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Sbjct: 717 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 752

>gi|12835158|dbj|BAB23172.1| (AK004105) putative [Mus musculus]
          Length = 484

 Score =  753 bits (1944), Expect = 0.0
 Identities = 390/484 (80%), Positives = 418/484 (85%), Gaps = 4/484 (0%)

Query: 277 ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLG 336
           ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESIL+RVQQHIESKLLG
Sbjct: 1   ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILQRVQQHIESKLLG 60

Query: 337 SNSSRMYFTQTLLPGLAGPSGEMVKXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAF 396
           SNSSRMYFTQTLLPGLAGPSGE  +              DKVYA+QMVRTDSREQKLDAF
Sbjct: 61  SNSSRMYFTQTLLPGLAGPSGEAARPTTGVASSSTSGSGDKVYAYQMVRTDSREQKLDAF 120

Query: 397 LQPLSKPLSSQPQ--AIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKG 454
           LQP+S    SQPQ  A V   +T+ S  RA ++DEEML LPAPAE AA++++LE ++   
Sbjct: 121 LQPVSSLGPSQPQDPAPVRGARTEGSPERATREDEEMLALPAPAEAAAESENLERESLME 180

Query: 455 TSEMSEKRGPTSS--NPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEE 512
           TS+ ++K  PTSS  + RKRHR             KEMTAAC PRRRIINLTSVLSLQEE
Sbjct: 181 TSDAAQKAAPTSSPGSSRKRHREDSDVEMVENASGKEMTAACYPRRRIINLTSVLSLQEE 240

Query: 513 INEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFG 572
           I+E+ HE LREML NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFG
Sbjct: 241 ISERCHETLREMLRNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFG 300

Query: 573 VLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDE 632
           VLRLSEPAPLFD AMLALDSPESGWTE+DGPKEGLAEYIVEFLKKKAEMLADYFS+EIDE
Sbjct: 301 VLRLSEPAPLFDRAMLALDSPESGWTEDDGPKEGLAEYIVEFLKKKAEMLADYFSVEIDE 360

Query: 633 EGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYIS 692
           EGNLIGLPLLID+YVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYI 
Sbjct: 361 EGNLIGLPLLIDSYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYIL 420

Query: 693 EESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKV 752
           EESTLSGQQS++PGS    WKWTVEHI+YKA RSH+LPPKHFTEDGN+LQLANLPDLYKV
Sbjct: 421 EESTLSGQQSDMPGSTSKPWKWTVEHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLYKV 480

Query: 753 FERC 756
           FERC
Sbjct: 481 FERC 484

>gi|13543339|gb|AAH05833.1|AAH05833 (BC005833) Similar to mutL (E. coli) homolog 1 (colon cancer,
           nonpolyposis type 2) [Homo sapiens]
 gi|13543417|gb|AAH05866.1|AAH05866 (BC005866) Similar to mutL (E. coli) homolog 1 (colon cancer,
           nonpolyposis type 2) [Homo sapiens]
          Length = 374

 Score =  731 bits (1886), Expect = 0.0
 Identities = 362/374 (96%), Positives = 362/374 (96%)

Query: 383 MVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAA 442
           MVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAA
Sbjct: 1   MVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAA 60

Query: 443 KNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRIIN 502
           KNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR            RKEMTAACTPRRRIIN
Sbjct: 61  KNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIIN 120

Query: 503 LTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ 562
           LTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ
Sbjct: 121 LTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ 180

Query: 563 ILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEML 622
           ILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEML
Sbjct: 181 ILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEML 240

Query: 623 ADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM 682
           ADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM
Sbjct: 241 ADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM 300

Query: 683 FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQ 742
           FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQ
Sbjct: 301 FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQ 360

Query: 743 LANLPDLYKVFERC 756
           LANLPDLYKVFERC
Sbjct: 361 LANLPDLYKVFERC 374

>gi|7304079|gb|AAF59117.1| (AE003838) Mlh1 gene product [Drosophila melanogaster]
          Length = 664

 Score =  615 bits (1586), Expect = e-175
 Identities = 335/751 (44%), Positives = 453/751 (59%), Gaps = 94/751 (12%)

Query: 6   GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
           GVIR+LDE VVNRIAAGE+IQRPANA+KE++EN LDA+ST IQV VK GGLKL+QIQDNG
Sbjct: 8   GVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNG 67

Query: 66  TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCA 125
           TGIR+EDL IVCERFTTSKL  FEDL+ I+T+GFRGEALASISHVAH++I TKTA  KC 
Sbjct: 68  TGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCG 127

Query: 126 YRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSV 185
           Y+A+Y+DGKL+  PKPCAGNQGT I +EDLFYN+  RR+AL++P+EE+ ++ EV+ RY+V
Sbjct: 128 YKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAV 187

Query: 186 HNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
           HN  + F+++KQG+    +RT   +S  +NIR I+G A+S+EL+E    D+   F+    
Sbjct: 188 HNPRVGFTLRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECL 247

Query: 246 ISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
           I+  NYS KKC  LLFIN RLVEST+LR +++++YA YLP+  HPF+Y+SL + PQN+DV
Sbjct: 248 ITQVNYSAKKCQMLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDV 307

Query: 306 NVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKXXXX 365
           NVHPTKHEVHFL++E I++ ++Q +E++LLGSN++R ++ Q  LPG   P  +  +    
Sbjct: 308 NVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPG--APDLDETQ---- 361

Query: 366 XXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRAR 425
                      ++Y  +MVRTDS EQKLD FL PL K  S    +   E         A 
Sbjct: 362 -----LADKTQRIYPKEMVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQE---------AS 407

Query: 426 QQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXXXXXXX 485
           +  EE   + A                                  K+ R           
Sbjct: 408 RLPEESFRVTAA---------------------------------KKSREVRLSSVLDMR 434

Query: 486 XRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQT 545
            R E   +   R  + NL  V  + E      HE    M +  SF               
Sbjct: 435 KRVERQCSVQLRSTLKNLVYVGCVDERRALFQHETRLYMCNTRSF--------------- 479

Query: 546 KLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKE 605
                     SEELFYQ +IY+F N   + +S P PL +L +L+L+S  +GWT EDG K 
Sbjct: 480 ----------SEELFYQRMIYEFQNCSEITISPPLPLKELLILSLESEAAGWTPEDGDKA 529

Query: 606 GLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVN 665
            LA+   + L KKA ++ +YF L I E+G L  LP L+  + P +  LP+++LRLATEV+
Sbjct: 530 ELADGAADILLKKAPIMREYFGLRISEDGMLESLPSLLHQHRPCVAHLPVYLLRLATEVD 589

Query: 666 WDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALR 725
           W++E  CFE+  +E A FY+              Q     G+     +WT+EH+++ A +
Sbjct: 590 WEQETRCFETFCRETARFYA--------------QLDWREGATAGFSRWTMEHVLFPAFK 635

Query: 726 SHILPPKHFTEDGNILQLANLPDLYKVFERC 756
            ++LPP    +   I +L NLP LYKVFERC
Sbjct: 636 KYLLPPPRIKD--QIYELTNLPTLYKVFERC 664

>gi|3192877|gb|AAC19117.1| (AF068257) mutL homolog [Drosophila melanogaster]
          Length = 663

 Score =  608 bits (1568), Expect = e-173
 Identities = 334/751 (44%), Positives = 453/751 (59%), Gaps = 95/751 (12%)

Query: 6   GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
           GVIR+LDE VVNRIAAGE+IQRPANA+KE++EN LDA+ST IQV VK GGLKL+QIQDNG
Sbjct: 8   GVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNG 67

Query: 66  TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCA 125
           TGIR+EDL IVCERFTTSKL  FEDL+ I+T+GFRGEALASISHVAH++I TKTA  KC 
Sbjct: 68  TGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCG 127

Query: 126 YRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSV 185
           Y+A+Y+DGKL+  PKPCAGNQGT I +EDLFYN+  RR+AL++P+EE+ ++ EV+ RY+V
Sbjct: 128 YKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAV 187

Query: 186 HNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
           HN  + F+++KQG+    +RT   +S  +NIR I+G A+S+EL+E    D+   F+    
Sbjct: 188 HNPRVGFTLRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECL 247

Query: 246 ISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
           I+  NYS KKC  LLFIN RLVEST+LR +++++YA YLP+  HPF+Y+SL + PQN+DV
Sbjct: 248 ITQVNYSAKKCQMLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDV 307

Query: 306 NVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKXXXX 365
           NVHPTKHEVHFL++E I++ ++Q +E++LLGSN++R ++ Q  LPG   P  +  +    
Sbjct: 308 NVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPG--APDLDETQ---- 361

Query: 366 XXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRAR 425
                      ++Y  +MVRTDS EQKLD FL PL K  S    +   E         A 
Sbjct: 362 -----LADKTQRIYPKEMVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQE---------AS 407

Query: 426 QQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXXXXXXX 485
           +  EE   + A                                  K+ R           
Sbjct: 408 RLPEESFRVTAA---------------------------------KKSREVRLSSVLDMR 434

Query: 486 XRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQT 545
            R E   +   R  + NL  V  + E      HE    M +  SF               
Sbjct: 435 KRVERQCSVQLRSTLKNLVYVGCVDERRALFQHETRLYMCNTRSF--------------- 479

Query: 546 KLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKE 605
                     SEELFYQ +IY+F N   + +  P PL +L +L+L+S  +GWT ED  K 
Sbjct: 480 ----------SEELFYQRMIYEFQNCSEITICPPLPLKELLILSLESRAAGWTPEDEDKA 529

Query: 606 GLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVN 665
            LA+   + L KKA ++ +YF L I E+G L  LP L+  + P +  LP+++LRLATEV+
Sbjct: 530 ELADGAADILLKKAPIMREYFGLRISEDGMLESLPSLLHQHRPCVAHLPVYLLRLATEVD 589

Query: 666 WDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALR 725
           W++E  CFE+  +E A FY+              Q     G+     +WT+EH+++ A +
Sbjct: 590 WEQETRCFETFCRETARFYA--------------QLDWREGATAVFSRWTMEHVLFPAFK 635

Query: 726 SHILPPKHFTEDGNILQLANLPDLYKVFERC 756
            ++LPP+   +D  I +L NLP LYKVFERC
Sbjct: 636 KYLLPPR--IKD-QIYELTNLPTLYKVFERC 663

>gi|460627|gb|AAA16835.1| (U07187) Mlh1p [Saccharomyces cerevisiae]
          Length = 769

 Score =  471 bits (1213), Expect = e-132
 Identities = 292/788 (37%), Positives = 448/788 (56%), Gaps = 62/788 (7%)

Query: 8   IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
           I+ LD +VVN+IAAGE+I  P NA+KEM+EN +DA +T I ++VKEGG+K++QI DNG+G
Sbjct: 5   IKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSG 64

Query: 68  IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
           I K DL I+CERFTTSKLQ FEDL+ I TYGFRGEALASISHVA VT+TTK  + +CA+R
Sbjct: 65  INKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWR 124

Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
            SY++GK+   PKP AG  GT I VEDLF+NI +R +AL++ ++EY KIL+VVGRY++H+
Sbjct: 125 VSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAIHS 184

Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEI---GCEDKTLAFKMNG 244
             I FS KK G++   +   P+ +  D IR++F  +V+  LI       ED  L   ++G
Sbjct: 185 KDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITFHISKVEDLNLE-SVDG 243

Query: 245 YISNANYSVKKCIFLL-FINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
            + N N+  KK I L+ FIN+RLV    LR+A+ +VY+ YLPK   PF+YL + I P  V
Sbjct: 244 KVCNLNFISKKSISLIFFINNRLVTCDLLRRALNSVYSNYLPKGFRPFIYLGIVIDPAAV 303

Query: 304 DVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTL---LPGLAGPSGEMV 360
           DVNVHPTK EV FL ++ I+E++   + ++L   ++SR +   ++    P    P  + +
Sbjct: 304 DVNVHPTKREVRFLSQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPFNDTI 363

Query: 361 KXXXXXXXXXXXXXXDKVYA-------------HQMVRTDSREQKLDAFL---QPLSKPL 404
           +              +  Y              +++VR D+ + K+ +FL   Q  +   
Sbjct: 364 ESDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLSSSQQFNFEG 423

Query: 405 SSQPQAIVTEDKTDISSGRARQQDEEMLEL---PAPAEVAAKNQSLEGDTTKGTSEMSEK 461
           SS  + +     T++S      Q+ E L L     P +    N +   D  K   ++ + 
Sbjct: 424 SSTKRQLSEPKVTNVS----HSQEAEKLTLNESEQPRDANTINDNDLKDQPKKKQKLGDY 479

Query: 462 RGPTSSNPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRI-INLTSVLSLQEEINEQGHEV 520
           + P+ ++  K                        P+ R+ +NLTS+  L+E++++  H  
Sbjct: 480 KVPSIADDEKNALPISKDGYIR-----------VPKERVNVNLTSIKKLREKVDDSIHRE 528

Query: 521 LREMLHNHSFVGCVNPQWALA--QHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSE 578
           L ++  N ++VG V+ +  LA  QH  KL+L++   +  ELFYQI + DFANFG + L  
Sbjct: 529 LTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDFANFGKINLQS 588

Query: 579 PAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEG---- 634
                D+ +  L S E     +D  KE +   I +     + ML +Y+S+E+  +G    
Sbjct: 589 TNVSDDIVLYNLLS-EFDELNDDASKEKIISKIWDM----SSMLNEYYSIELVNDGLDND 643

Query: 635 ----NLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFY--SIRK 688
                L  LPLL+  Y+P L  LP FI RL  EV+W++E+EC + + +E A+ Y   +  
Sbjct: 644 LKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVP 703

Query: 689 QYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPD 748
           +  + +++LS  +     +        +EH+++  ++   L P+H  +D  ++++ANLPD
Sbjct: 704 KVDTLDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKD--VVEIANLPD 761

Query: 749 LYKVFERC 756
           LYKVFERC
Sbjct: 762 LYKVFERC 769