Leucine zippers provide dimerization interactions for some eucaryotic transcription factors The Leucine Zipper motif was first recognized in a yeast transcription factor GCN4, the mammalian transcription factor C/EBP, and three oncogene products, Fos , Jun and Myc The original model was first proposed by Steven Mcnight in 1988 The modified model was proposed by Peter Kim in 1989
(a) GCN4, (b) Max, (c) Fos, (d) Jun
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