The functions of DMSO.

They hypoyhesize that the enzymetic specificity might result form a selective recognition of the phenyl moiety and the oxim structure by the HIV-1 protease ,and that inhibition is a result of an accompanying irreversible reaction betwween the halogenomethylketone moiety and the surrounding amino acids.

Cytotoxicity:cell viability was 50% reduced by culture for 24h with compound 1.This may be due to halogenomethylketone moiety.

may found a new lead structure for the design of simple and non-peptidyl HIV-1 protease inhibitors.