Introduction :HIV-1 protease and Anti-AIDS drugs

Functions:

• HIV-1 proteases transform Gag and Gag-pol precursor
  polypepides into mature protein that are essential for
  the production of infectious virues.

• HIV protease hydrolyzes peptide bonds at a number sites
  including characteristic Tyr/Phe-Pro sequence.

Structure:

• HIV-1 protease is a symmetric dimer with the critical aspartate pair at
  the subunit interface.

Inhibitions:

• 

• Specifity of inhibitor is a main point in designing a anti-AIDS drug.

• To identify compounds with new lead structure.

method and material