Cell-free proteolytic processing and HIV-1 protease inhibition studies.

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  Oxim derivatives containting halogenomethylketon an phenyl moieties were found to be particularly potent as inhibtors of the HIV-1 protease.

Specificity of inhibition.

Molecular modeling of inhibitor-protease complex.

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  compound 2:yellow	inhibitor complex JG365:green
  oxgen:red	nitrogen:blue
  bromine:pink	oxygen atoms of aspartic acid residues:red bars

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Anti HIVIIIB activity against chronic infection.

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• During the experimient(6h),cell viability was not reduced.