Structure of a Voltage-Dependent K+ Channel βSubunit Reference

Jacqueline M. Gulbis, Sabine Mann,and Roderick MacKinnnnon

Cell, Vol. 97, 943-952, June 25, 1999

學生： 簡汎佐 (884246)

摘要：

生物細胞膜上有一群調控離子進出的通道蛋白質，其作用機制受到膜電位變化的影 響。本篇作者利用X-ray結晶繞射學的方法解出解析度為2.8A的鉀離子通道βsubunit結構，進一步探討該次單元的4轉軸對稱性和αsubunit結合間的關係、反應活化區域對NADPH的氧化還原特性、對其他相似酵素的結構異同以及對整個通道 開關的調節途徑。

Reference:

  1. Doyle, D.A., Morais Cabral, J.H., Pfuetzner, R.A., Kuo, A., Gulbis, J.M., Cohen, S.L.,Chait, B.T., and MacKinnon, R.(1998)The structure of the potassium channel : molecule basis of K+ conduction and selectivity. Science 280, 69-77
  2. Xu, J., and Li, M. (1997) Kvbeta2 inhibits the Kvbeta1-mediated inactivation of K+ channels in transfected mammalian cells. J. Biol. Chem. 272, 11728-11735.
  3. Diane M. Papazian (1999) Potassium Channels: Some Assembly Required Neuron, Vol. 23, 7-10Aro, E.-M., Hundal, T., Carlberg, I. & Andersson, B. (1990) Biochim. Biophys. Acta 1019, 269-275.

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