Sequence Homology v.s. Folding Topology

Only Src and Fyn-SH3 domains have high sequence homology up to 78%, and other SH3 domains share sequence homology as low as 20-30%. However, their folding topology are alomst identical.

[Multiple sequence alignment of EBI-alignment tool ClustalW][Home]

Danny S. Hsu 1999-2000. All rights reserved.