Crystal Structure of a SNARE Complex Involved in Synaptic Exocytosis at 2.4 A Resolution
Before we start our topic, let¡¦s see some examples of all helix and helix dominate protein structures!
Multimeric Alpha Helix Bundle
More Helix Bunble Protein
SNARE (soluble NSF-attachment protein)
Structural Features
Electron-Density Map of the Synaptic Fusion Complex
Topology and Organization of the Synaptic Fusion Complex
Methionine Cluster Layer
Ionic ¡§0¡¨ Layer of the Synaptic Fusion Complex
SN2 Loop in Hydrophobic Groove
Hypothetical Model of Synaptic Fusion Complex and Neurotoxin-mediated Cleavage Sites
Surface Electrostatic Potential Plot
Homo-oligomeric and Heterotrimeric Membrane Fusion Protein
Discussion
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