PowerPoint 簡報
Unlike other homo-oligomeric alpha-helical bundles such as HIV/SIV gp41 and the influenza virus haemagglutinin crystal structures, SNAREs is a hetero-trimeric, parallel four-helix gundle. Each individual component shows little fusion ability, unlike viral fusion proteins. The structural studying about SNARE explains its special features. Yet, the membrane fusion process like lipid mixing remains unclear and further study is going. Perhaps this process is regulated by accessory proteins, ehich could link Ca++-dependent exocytosis and the synaptic fusion complex.