SWISS-PROT: P50503
ID HIP_RAT
STANDARD; PRT; 368 AA.
AC P50503;
DT 01-OCT-1996 (REL. 34, CREATED)
DT 01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE)
DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE HSC70-INTERACTING PROTEIN.
GN HIP.
OS RATTUS NORVEGICUS (RAT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA;
MAMMALIA;
OC EUTHERIA; RODENTIA.
RN [1]
RP SEQUENCE FROM N.A.
RC STRAIN=SPRAGUE-DAWLEY;
RX MEDLINE; 96069860. [NCBI, Geneva]
RA HOEHFELD J., MINAMI Y., HARTL F.-U.;
RL CELL 83:589-598(1995).
CC -!- FUNCTION: ONE HIP OLIGOMER BINDS THE ATPASE DOMAINS
OF AT LEAST
CC TWO HSC70 MOLECULES DEPENDENT
ON ACTIVATION OF THE HSC70 ATPASE BY
CC HSP40. STABILIZES THE ADP STATE
OF HSC70 THAT HAS A HIGH AFFINITY
CC FOR SUBSTRATE PROTEIN. THROUGH
ITS OWN CHAPERONE ACTIVITY, IT MAY
CC CONTRIBUTE TO THE INTERACTION
OF HSC70 WITH VARIOUS TARGET
CC PROTEINS. INTERACTS WITH HSC70
AS WELL AS DNAJ HOMOLOGS AND HSP90.
CC -!- SUBUNIT: HOMOTETRAMER.
CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC.
CC -!- SIMILARITY: CONTAINS 3 COPIES OF THE TPR DOMAIN.
DR EMBL; X82021; E120639; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PRODOM [Domain structure / List of seq. sharing at least
1 domain]
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW CHAPERONE; TPR DOMAIN; REPEAT.
FT REPEAT 113
146 TPR 1.
FT REPEAT 147
180 TPR 2.
FT REPEAT 181
214 TPR 3.
FT DOMAIN 278
311 GLY/MET/PRO-RICH.
FT DOMAIN 316
368 STI1-C-TERMINAL.
SQ SEQUENCE 368 AA; 41279 MW; C914D171
CRC32;
MDPRKVSELR AFVKMCRQDP SVLHTEEMRF LREWVESMGG
KVPPATHKAK SEENTKEEKR
DKTTEDNIKT EEPSSEESDL EIDNEGVIEA DTDAPQEMGD
ENAEITEAMM DEANEKKGAA
IDALNDGELQ KAIDLFTDAI KLNPRLAILY AKRASVFVKL
QKPNAAIRDC DRAIEINPDS
AQPYKWRGKA HRLLGHWEEA ARDLALACKL DYDEDASAML
REVQPRAQKI AEHRRKYERK
REEREIKERI ERVKKAREEH EKAQREEEAR RQSGSQFGSF
PGGFPGGMPG NFPGGMPGMG
GAMPGMAGMP GLNEILSDPE VLAAMQDPEV MVAFQDVAQN
PSNMSKYQNN PKVMNLISKL
SAKFGGHS
//
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P50503 in FASTA format