figure4

How mutation at Asp187 cause FAF

Finished Type Familial Amyloidosis(FAF) is a disease with loosed facial skin and participation of amyloid in nerve cells
  1. Red region is S1. Yellow and Cyan regions comprise the F-actin binding site of S2. Cyan and orange regions comprise PIP2(inhibitor of F-actin binding) binding site.
  2. Asp187 is within binding distance with three residues and these forces stablize the local region. When Asp187 is mutated, a trypsin-like protease site at Arg172-Ala173 is likely to be cutted. The red and purple regions are amyloidosis fragement.