| Transgenic technology is the introduction of a gene(s) from one species into the DNA of another. PPL is a pioneer in using this technology for the production of therapeutic human proteins in the milk of livestock. |
| In the current methods for production of transgenic animals, the gene of interest is introduced into a fertilised egg and becomes integrated into the host DNA. The gene is linked to a piece of DNA, called the promoter, which makes it active only in certain parts of the transgenic animal. In PPL Therapeutics' case, genes encoding human proteins are expressed so that the protein is produced in the animal's milk. Because the protein is produced only in the milk, the animal is normal and healthy. |
| PPL has used this technology to produce therapeutic proteins in the milk of a variety of mammals including mice, rabbits, sheep and cows. |
| Transgenic animals have the potential to economically produce many important pharamceutical proteins. For example, PPL Therapeutics' leading product, produced in sheep, is a potential drug for the treatment of cystic fibrosis. |