Introduction of ExPASy Molecular Biology Serever
The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bio-informatics (SIB) contains protein sequences, structures and 2-D PAGE databases, and also offers the analysis tools of them.
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Databases
| SWISS-PROT and TrEMBL | SWISS-PROT provides a high level of annotations (protein function, structure, post-translational modifications, variants...) and integration with other databases; TrEMBL is a computer-annotated supplement of SWISS-PROT. |
| PROSITE | PROSITE is a database of protein families and domains. It consists of biologically significant sites, patterns and profiles that help to reliably identify to which known protein family (if any) a new sequence belongs. |
| SWISS-2DPAGE | SWISS-2DPAGE contains data on proteins identified on various 2-D PAGE and SDS-PAGE reference maps. |
| SWISS-3DIMAGE | SWISS-3DIMAGE provides 3 D structure of biological macromolecules. The database contains both experimentally elucidated structures and theoretical protein models. (The mono and stereo pictures are available.) |
| SWISS-MODEL Repository | Automatically generated protein models |
| CD40Lbase | The purpose of the CD40Lbase is to collect clinical and molecular data on CD40 ligand defects leading to X-linked Hyper-IgM syndrome |
| ENZYME | ENZYME is a repository of information relative to the nomenclature of enzymes. It describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided |
| SeqAnalRef | SeqAnalRef is a bibliographic reference data bank relative to papers dealing with sequence analysis. |
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tools and software
packages
| Proteomics tools | Identification and
characterization DNA --> Protein Similarity searches Pattern and profile searches Post-translational modification prediction Primary structure analysis Secondary structure prediction Tertiary structure Transmembrane regions detection Alignment |
| Melanie 3 | Melanie 3 is the all-in-one solution for analyzing, annotating and querying your 2D gel samples. It offers sophisticated state-of-the-art analysis for the identification, quantification and matching of gels. |
| SWISS-MODEL | SWISS-MODEL is an Automated Protein Modelling Server. |
| Swiss-PdbViewer | The proteins can be superimposed in order to deduce structural alignments and compare their active sites or any other relevant parts, so amino acid mutations, H-bonds, angles and distances between atoms are easy to obtain. |
| Boehringer Mannheim's Biochemical Pathways | This list contains links to the ENZYME Database and to all maps of "Biochemical Pathways" in which this entry appears. |
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