History of Development

1. Weismann's theory : Nuclear determinant.

Point 1. Determinant: factors that be distributed unequally to the daughter cells and would control the cells' future development. 2. Assymetric division

2. (1888) Wilheim Roux : support Weismann's idea by experiment with frog embryos [defect exp.].

3. (1892) Hans Driesch : Demonstration of regulation development by sea urchin embryos [isolation exp.].

˙Nuclear equivalent

˙Cell-cell interaction

4. (1910) McClendon : Fate mapping of frog embryos.

5. (1924) Spemann : Organizer transplant experiment.