| GENPEPT:1724118 | Rattus norvegicus mismatch repair protein (MLH1) mRNA, complete |
| GENPEPT:3192877 | Drosophila melanogaster mutL homolog (Mlh1) gene, complete cds_ |
| GENPEPT:7595954 | Mus musculus MutL homolog 1 protein (MLH1) mRNA, complete cds. |
| GENPEPT:460627 | Saccharomyces cerevisiae DNA mismatch repair (MLH1) gene, complete |
| MLH1_HUMAN | DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1) [Homo sapiens (Human)] |
| C_elegans_gene:3876842_emb_CAA98478.1_ | 3876842 similar to DNA mismatch repair protein_ cDNA EST EMBL:D37616 comes from this gene_ cDNA EST EMBL:D68353 comes from this gene_ cDNA EST EMBL:D68679 comes from this gene_ cDNA EST EMBL:C12838 comes from this gene_ cDNA EST EMBL:D67162 comes from this gene |
Consensus key (see documentation for details)
* - single, fully conserved residue
: - conservation of strong groups
. - conservation of weak groups
- no consensus
CLUSTAL W (1.81) multiple sequence alignment
GENPEPT_7595954 --MAFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQ
GENPEPT_1724118 --MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMTENCLDAKSTNIQ
MLH1_HUMAN --MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQ
GENPEPT_3192877 MAEYLQPGVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQ
GENPEPT_460627 -----MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMID
C_elegans_gene_3876842_emb_C ----MSQNKIERISKEVAERLTTAQVVVSLSSAIRQLIDNSIDAGSTIID
*. :. *.:::::.::: .*:::: :*.:** :* *:
GENPEPT_7595954 VVVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLASISTYG
GENPEPT_1724118 VIVREGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLAMISTYG
MLH1_HUMAN VIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYG
GENPEPT_3192877 VQVKAGGLKLLQIQDNGTGIRREDLAIVCERFTTSKLTRFEDLSQIATFG
GENPEPT_460627 ILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYG
C_elegans_gene_3876842_emb_C IRVKNNGFESIEVQDNGSGIEARNFDALCKPHSTSKLTQFSDFDKLATLG
: *: .*:: ::: ***:**. :: :*: .:**** *.*: : * *
GENPEPT_7595954 FRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGT
GENPEPT_1724118 FRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGT
MLH1_HUMAN FRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGT
GENPEPT_3192877 FRGEALASISHVAHLSIQTKTAKEKCGYKATYADGKLQGQPKPCAGNQGT
GENPEPT_460627 FRGEALASISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGT
C_elegans_gene_3876842_emb_C FRGEALNALCTVSSVSIFTRASDTEIGTRLTYDHSGNIICRQSAARELGT
****** ::. *: ::: *:. . . . : :* .. :. * : **
GENPEPT_7595954 LITVEDLFYNIITRRKALK-NPSEEYGKILEVVGRYSIHNSGISFSVKK-
GENPEPT_1724118 LITVEDLFYNIITRKKALK-NPSEEYGKILEVVGRYSIHNSGISFSVKK-
MLH1_HUMAN QITVEDLFYNIATRRKALK-NPSEEYGKILEVVGRYSVHNAGISFSVKK-
GENPEPT_3192877 IICIEDLFYNMPQRRQALR-SPAEEFQRLSEVLARYAVHNPRVGFTLRK-
GENPEPT_460627 TILVEDLFFNIPSRLRALR-SHNDEYSKILDVVGRYAIHSKDIGFSCKK-
C_elegans_gene_3876842_emb_C TIIVNKLFETLPVRRKELERSQKREFVKLLSTVQSFALLCPHIKILCTNN
* ::.** .: * : *. . *: :: ..: ::: : : :
GENPEPT_7595954 -QGETVSDVRTLPNATTVDNIRS--------IFGNAVSRELIEVG-----
GENPEPT_1724118 -QGETVSDVRTLPNATTVDNIRS--------IFGNAVSRELIEVG-----
MLH1_HUMAN -QGETVADVRTLPNASTVDNIRS--------IFGNAVSRELIEIG-----
GENPEPT_3192877 -QGDAQPALRTPVASSRSENIRI--------IYGAAISKELLEFS-----
GENPEPT_460627 -FGDSNYSLSVKPSYTVQDRIRT--------VFNKSVASNLITFHI----
C_elegans_gene_3876842_emb_C INGKKTNLICTPGGTTSIQDVVANLFGIARKIENSKIGSGLIPIQQNQPD
*. : . : : : : . :. *: .
GENPEPT_7595954 -----------CEDKTLAFK-MNGYISNANYSVKKCI---FLLFINHRLV
GENPEPT_1724118 -----------CEDKTLAFK-MNGYISNANYSVKKCI---FLLFINHRLV
MLH1_HUMAN -----------CEDKTLAFK-MNGYISNANYSVKKCI---FLLFINHRLV
GENPEPT_3192877 -----------HRDEVYKFE-AECLITQVNYSAKKCQ---MLLFINQRLV
GENPEPT_460627 -----------SKVEDLNLESVDGKVCNLNFISKKSIS--LIFFINNRLV
C_elegans_gene_3876842_emb_C VEIMTIHSVPMEEMHFFDLFKIRGFVSSCEHGCGRGTSDRQFVYINNRPV
. . : : . :. : :.:**:* *
GENPEPT_7595954 ESAALRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFL
GENPEPT_1724118 ESAALKKAIEAVYAAYLPKNTHPFLYLILEISPQNVDVNVHPTKHEVHFL
MLH1_HUMAN ESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFL
GENPEPT_3192877 ESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFL
GENPEPT_460627 TCDLLRRALNSVYSNYLPKGFRPFIYLGIVIDPAAVDVNVHPTKREVRFL
C_elegans_gene_3876842_emb_C EYSRVCSVINDVYKQFNKK-QYPIIVLFIDVPPEKIDVNVTPDKKTVMLE
: :: :* : : *:: : : : * :**** * *: * :
GENPEPT_7595954 HEESILQRVQQHIESKLLGSNSSRMYFTQTLLPGLAG---------PSGE
GENPEPT_1724118 HEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAG---------PSGE
MLH1_HUMAN HEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAG---------PSGE
GENPEPT_3192877 YQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPGAP--------------
GENPEPT_460627 SQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPF---NDTIE
C_elegans_gene_3876842_emb_C KERHLLAVVRASMMKTYLKIVGSHSTVRSSVEDRRIMNLSQQSFSNASFM
: :: : : :: .
GENPEPT_7595954 AARPTTGVASSSTSGSGDKVYAYQMVRTDSRDQKLDAFLQPVSSLVPSQP
GENPEPT_1724118 AVKSTTGIASSSTSGSGDKVHAYQMVRTDSRDQKLDAFMQPVSRRLPSQP
MLH1_HUMAN MVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQP
GENPEPT_3192877 ------DLDETQLADKTQRIYPKEMVRTDSTEQKLDKFLAPLVK------
GENPEPT_460627 SDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLS
C_elegans_gene_3876842_emb_C SSKSSTPDDFNNTTLNSTYPEDSLLNTSDLLKQRKENRSPPAKKSCPMIR
. . : :. .:: .
GENPEPT_7595954 QDPAPVRGARTEGSPERATREDEEMLALPAPAEAAAESENLERESLMETS
GENPEPT_1724118 QD--PVPGNRTEGSPEKAMQKDQEISELPAPMEAAADSASLERESVIGAS
MLH1_HUMAN Q--AIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTS
GENPEPT_3192877 --------------------------------------------------
GENPEPT_460627 SS--QQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTLNESEQPRDANTIN
C_elegans_gene_3876842_emb_C RT----EPFHSVPSTSNSRTQRLENFSFTMEPKRVEVSKKIPSKSDKKLT
GENPEPT_7595954 DAAQKAAPTSSPGSSRKRHREDSDVEMVENASGKEMTAACYPRRRIINLT
GENPEPT_1724118 EVVAPQRHPSSPGSSRKRHPEDSDVEMMENDSRKEMTAACYPRRRIINLT
MLH1_HUMAN EMSEKRGPTSS--NPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLT
GENPEPT_3192877 ---SDSGVSSSSSQEASRLPEES------------FRVTAAKKSREVRLS
GENPEPT_460627 DNDLKDQPKKKQKLGDYKVPSIADDEKNALPISKDGYIRVPKERVNVNLT
C_elegans_gene_3876842_emb_C DEELRSAVIEENPLKKAGEIDDIEILEQSQESQDVNESQCSQDSQTSQNS
.. . . :
GENPEPT_7595954 SVLSLQEEISERCHETLREILRNHS-FVGCVNPQW--ALAQHQTKLYLLN
GENPEPT_1724118 SVLSLQEEINDRGHETLREMLRNHT-FVGCVNPQW--ALAQHQTKLYLLN
MLH1_HUMAN SVLSLQEEINEQGHEVLREMLHNHS-FVGCVNPQW--ALAQHQTKLYLLN
GENPEPT_3192877 SVLDMRKRVERQCSVQLRSTLKNLV-YVGCVDERR--ALFQHETRLYMCN
GENPEPT_460627 SIKKLREKVDDSIHRELTDIFANLN-YVGVVDEERRLAAIQHDLKLFLID
C_elegans_gene_3876842_emb_C RVSYFTLRPQQKIKFSMKLLREAYSPKTDETDDNTEEAEVSAEKDVLNEI
: : . . : .. .: . * . : :
GENPEPT_7595954 TTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEDD
GENPEPT_1724118 TTKLSEELFYQILIYDFANFGVLRLPEPAPLFDFAMLALDSPESGWTEED
MLH1_HUMAN TTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEED
GENPEPT_3192877 TRSFSEELFYQRMIYEFQNCSEITICPPLPLKELLILSLESRAAGWTPED
GENPEPT_460627 YGSVCYELFYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFDELN-DD
C_elegans_gene_3876842_emb_C TTKINKEENDDAERQLSRSLTKDDFSKMKIIGQFNHGFIICRLRGHLFIV
.. * : . : :: : .
GENPEPT_7595954 GPKEGLAEYIVEFLKKKAEMLADYFSVEIDEEGN--------LIGLPLLI
GENPEPT_1724118 GPKEGLAEYIVEFLKKKAKMLADYFSVEIDEEGN--------LIGLPLLI
MLH1_HUMAN GPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGN--------LIGLPLLI
GENPEPT_3192877 EDKAELADGAADILLKKAPIMREYFGLRISEDGM--------LESLPSLL
GENPEPT_460627 ASK----EKIISKIWDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLLL
C_elegans_gene_3876842_emb_C DQHASDEKYNFERLQSSAKLTKQPLFMPT-ALGFGAVQELIIRENLPIFH
: . . : . : : : : * .** :
GENPEPT_7595954 DS-----YVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRK
GENPEPT_1724118 DS-----YVPPLEGLPIFILRLATEVNWDEE-ECFESLSKECAVFYSIRK
MLH1_HUMAN DN-----YVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRK
GENPEPT_3192877 HQ-----HRPCVAHLPVYLLRLATEVDWEQETRCFETFCRETARFY----
GENPEPT_460627 KG-----YIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDM
C_elegans_gene_3876842_emb_C ANGFDFEFSENDGCIKTFLTARPELLNQQLTNSDLEEILAVVSQYPNQMY
. : :: :: : :: : :
GENPEPT_7595954 QYILEESTLSGQQSDMPGSTSKPWKWT--VEHIIYKAFRSHLLPPKHFTE
GENPEPT_1724118 QYILEESALSGQQSDMPGSPSKPWKWT--VEHIIYKAFRSHLLPPKHFTE
MLH1_HUMAN QYISEESTLSGQQSEVPGSIPNSWKWT--VEHIVYKALRSHILPPKHFTE
GENPEPT_3192877 ----------AQLDWREGATAVFSRWT--MEHVLFPAFKKYLLPPR---I
GENPEPT_460627 VPKVDTLDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILK
C_elegans_gene_3876842_emb_C RPVRIRKIFASKACRKSVMIGKPLNQR--EMTQIIRHLAKLDQPWNCPHG
. . : : . .
GENPEPT_7595954 DGNVLQLANLPDLYKVFERC
GENPEPT_1724118 DGNVLQLANLPDLCKVFERC
MLH1_HUMAN DGNILQLANLPDLYKVFERC
GENPEPT_3192877 KDQIYELTNLPTLYKVFERC
GENPEPT_460627 D--VVEIANLPDLYKVFERC
C_elegans_gene_3876842_emb_C RPTIRHLASLPDRAEFE---
: .::.** :.