Search genes associated with colon cancer in human genome.

MLH1 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS.

1. How many hits will you get if you search genes associated with colon cancer in human genome?
   Ans. 17 hits
   
   
2. How many loci will you find if you search locus link for human in Genebank?
   Ans. 21 loci
   
   
3. Give the locus ID and position of MLH1.
   Ans. ID : 4292
   position : 3p21.3
   
   
4. Find the %ID of nucleotide sequence for its possible orthologs in mouse.
   Ans. Human MLH1 v.s Mouse Hmga1 %ID=90.5
   Human MLH1 v.s Mouse Mlh1 %ID=89.3
   
   
5. Find the total number of mutations of MLH1 reported in human gene mutation database.
   Ans. 147
   
   
6. Give the DNA sequence of MLH1.
   Ans. MLH1 sequence
   
   
7. Give the DNA sequence of E. coli mismatch repair gene mutS.
   Ans. mutS sequence