DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1) [Homo sapiens (Human)] (SWISSPROT:MLH1_HUMAN)
- and -
DNA REPAIR (PDBFINDER:1BKN_A)

Query:     >MLH1_HUMAN
           Length = 756
Reference: Query= 
         (756 letters)

>PDBFINDER:1BKN_A
          Length = 272

 Score =  123 bits (309), Expect = 1e-32
 Identities = 81/287 (28%), Positives = 144/287 (49%), Gaps = 30/287 (10%)

Query: 25  IQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSK 84
           ++RPA+ +KE++EN LDA +T I + ++ GG KLI+I+DNG GI+K++L +         
Sbjct: 1   VERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALAL------A 54

Query: 85  LQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAG 144
           + S +DL +I + GFRGEALASIS V+ +T+T++TA+ + A+                  
Sbjct: 55  IASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAW------------------ 96

Query: 145 NQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADV 204
            Q   +TV+   + + T  + L     E+  I E++ R ++    ++ ++   G+ V   
Sbjct: 97  -QAYAVTVKPAAHPVGTTLEVLDTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQY 155

Query: 205 RTLPNASTVD-NIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKC--IFLLF 261
           R +P     +  + +I G A   + + I  +   L   + G++++ N++      I   +
Sbjct: 156 RAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLT--LRGWVADPNHTTPALAEIQYCY 213

Query: 262 INHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVH 308
           +N R++    +  AI       L  +  P   L LEI P  V   VH
Sbjct: 214 VNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVSRLVH 260


 Score = 16.9 bits (32), Expect = 1.3
 Identities = 17/57 (29%), Positives = 28/57 (48%), Gaps = 8/57 (14%)

Query: 520 VLREMLHNHSF-VGCVNPQWALAQHQTKLYL-LNTTKLSEELFYQILIYDFANFGVL 574
           ++R+ L NH+    C +   A  Q    LYL ++  ++S       L++DF   GVL
Sbjct: 218 MMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVSR------LVHDFIYQGVL 268


Lambda     K      H
   0.320    0.136    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 445
Number of Sequences: 0
Number of extensions: 16
Number of successful extensions: 5
Number of sequences better than 10.0: 1
Number of HSP's better than 10.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2
length of query: 272
length of database: 756
effective HSP length: 33
effective length of query: 239
effective length of database: 690
effective search space:   164910
effective search space used:   164910
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 25 (14.4 bits)
S2: 25 (14.2 bits)

Citation

Algorithm Citation:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.
Program Citation:
National Center for Biotechnology Information, Bldg 38A, NIH, 8600 Rockville Pike,Bethesda, MD 20894