Curriculum Vitae

Name Chung-Chuan Lo (羅中泉) Address Institute of Systems Neuroscience
National Tsing Hua University
Hsinchu, 30013, Taiwan
Email
Telephone +886-3-574-2014
Webpage http://life.nthu.edu.tw/~lablcc ORCID https://orcid.org/0000-0001-7737-7250

Education

1998-2004 Boston University, Boston, Massachusetts
Ph. D. in Physics
Thesis title: Statistical Physics Approaches for Understanding Sleep-Wake Transitions
Thesis advisor: H. Eugene Stanley, Professor of Physics
1995-1997 National Taiwan University, Taipei, Taiwan
M. S. in Physics
Thesis title: Study of the Effect of Site Mutation on the Structural Stability of Cobra Cardiotoxin by Time-Resolved Fluorescence
Thesis advisor: Wunshain Fann, Joint Assistant Professor of Physics.
1991-1995 National Taiwan University, Taipei, Taiwan
B. S. in Physics
Project title: The Effect of Noises on a Cascaded Lorenz System
Project advisor: Yih-Yuh Chen, Associate Professor of Physics.

Employment

2025-present National Tsing Hua University, Hsinchu, Taiwan
Associate Dean, College of Life Sciences and Medicine
2018-present National Tsing Hua University, Hsinchu, Taiwan
Professor, Institute of Systems Neuroscience
2018-2024 National Tsing Hua University, Hsinchu, Taiwan
Director, Institute of Systems Neuroscience
2014-2018 National Tsing Hua University, Hsinchu, Taiwan
Associate professor, Institute of Systems Neuroscience
2009-2014 National Tsing Hua University, Hsinchu, Taiwan
Assistant professor, Institute of Systems Neuroscience
2008-2009 National Tsing Hua University, Hsinchu, Taiwan
Assistant professor, Institute of Bioinformatics and Structural Biology
2006-2008 Yale University, New Haven, CT.
Postdoc assistant (Supervisor, Dr. Xiao-Jing Wang).
Neural network modeling
2004-2006 Brandeis University, Waltham, MA.
Postdoc fellow (Supervisor, Dr. Xiao-Jing Wang).
Neural network modeling
1997-1998 Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
Research Assistant (Supervisor, Dr. W.-S. Fann)
Experiments on time-resolved fluorescence of conformational changes in protein.

Honors and Awards

2021 Future Tech Breakthrough Award (未來科技突破獎), Future Tech Expo 2021, Taipei, Taiwan (team award)
2020 Future Tech Breakthrough Award (未來科技突破獎), Future Tech Expo 2020, Taipei, Taiwan (team award)
2019 Future Tech Breakthrough Award (未來科技突破獎), Future Tech Expo 2019, Taipei, Taiwan (team award)
2017 Open Science Prize Finalist (team award)
2017 National Tsing Hua University College of Life Science Research Award
2014 National Tsing Hua University Publication Award
2011 Best paper award. Symposium on Engineering, medicine and biology application, Taichung, Taiwan
2010 National Tsing Hua University Publication Award
2004-2007 Postdoctoral fellowship in computational neuroscience (Sloan-Swartz foundation)
2003 American Physical Society travel awards for Annual Meeting.
2001 Sigma Xi award, achievement in graduate research at Boston University.
2001 Travel scholarship for Sleep Medicine Conference, Marburg, Germany
1998-2003 Boston University Ph.D. research fellowship (2000-2003); teaching fellowship (1998-2000).
1991-1995 Ministry of Education (Taiwan) bachelor degree scholarship for outstanding students.

Professional Services

2024-present Associate editor of Frontiers in Neuroinformatics
2020-2023 Chairman of Taiwanese Society for Computational Neuroscience (https://www.sfcn.org.tw/)
2012-present Review editor of Frontiers in Decision Neuroscience
2011-2024 Review editor of Frontiers in Neuroinformatics
2011-2012 Technical program committee for Symposium on Engineering, Medicine and Biology Applications & International workshop on Bio-inspired Systems and Prosthetic Devices (Feb 11-13, 2012, Taichung, Taiwan)
2009-2013 Member of the task force for the multi-scale modeling, International Neuroinformatics Coordinating Facility (INCF)

Academic Publications

(*corresponding author)

  1. Fei-Yang Tzou, Cheng-Li Hong, Kai-Hung Chen, John P Vaughen, Wan-Syuan Lin, Chia-Heng Hsu, Irma Magaly Rivas-Serna, Kai-Yi Hsu, Shuk-Man Ho, Michael Raphael Panganiban, Hsin-Ti Hsieh, Yi-Jhan Li, Yi Hsiao, Hsin-Chun Yeh, Cheng-Yu Yu, Hong-Wen Tang, Ya-Hui Chou, Chia-Lin Wu, Chung-Chuan Lo, Vera C Mazurak, M Thomas Clandinin, Shu-Yi Huang and Chih-Chiang Chan* (2025). Functional profiling and visualization of thesphingolipid metabolic network in vivo. EMBO reports , 1-38.

  2. Che Liu, Chen-Fu Yeh and Chung-Chuan Lo* (2025). Selective Intersection Flow: A Lightweight Optical Flow Algorithm for Micro Drones. Engineering Proceedings 108(1), 47.

    3. Chen-Fu Yeh, Jia-Jun Lai, Sheng-Qian Li, Fang-Kai Hsiao, Jie-Min Jhang, Chung-Chuan Lo and Ya-Tang Yang* (2025). Implementation of an Efficient and Optical-Flow-Based Algorithm of Depth Estimation on Autonomous Nano Quadcopters for Obstacle Avoidance. 2025 11th International Conference on Control, Automation and Robotics (ICCAR) (pp. 596-600). IEEE.

  3. Rui Han*, Jun Zhang, Hao Huang, Yi-Jie Chen, Yu-Yuan Lu, Yu-Chen Wang, Chung-Chuan Lo, Yi-Heng Tan, Jia-Yi Li, Bao-Wei Pan, Ya-Lin Zhang* (2025). Effects of Coffee on Drosophila melanogaster: Concentration-Dependent Enhancement and Sleep Deprivation Recovery. Ethology, e70002.

  4. Li-Shan Cheng, Ching-Che Charng, Ruei-Huang Chen, Kuan-Lin Feng, Ann-Shyn Chian*, Chung-Chuan Lo*, Ting-Kuo Lee* (2025). Hybrid Neural Networks of the Olfactory Learning Center in the Drosophila Brain. Science Advances, 11(22), eadq9893.

  5. Chia-Wei Liu, Yi-Mei Wang, Shun-Ying Chen, Liang-Yin Lu, Ting-Yu Liang, Ke-Chu-Fang, Peng Chen, I-Chen Lee, Wen-Chuan Liu, Ami Kumar, Sheng-Han Kuo, Jye-Chang Lee, Chung-Chuan Lo, Shun-Chi Wu, Ming-Kai Pan* (2025). The cerebellum computes frequency dynamics for motions with numerical precision and cross-individual uniformity. Nature Biomedical Engineering, 1-20.

  6. Che Liu, Chen-Fu Yeh and Chung-Chuan Lo* (2025). SIF─A Lightweight Optical Flow Algorithm for Micro Drones. 2025 IEEE 5th International Conference on Electronic Communications, Internet of Things and Big Data (ICEIB)

  7. Chen-Fu Yeh, Jia-Jun Lai, Sheng-Qian Li, Fang-Kai Hsiao, Jie-Min Jhang, Chung-Chuan Lo and Ya-Tang Yang* (2025). Implementation of an efficient and optical-flow-based algorithm of depth estimation on autonomous nano quadcopters for obtacle avoidance. 2025 11th International Conference on Control, Automation and Robotics (ICCAR), 569-600.

  8. Heng Chang, Zhi-Yuan Chang, Kai-Chun Jhan, Chung-Chuan Lo, Shun-Chi Wu, Bi-Chang Chen, Li-An Chu* (2025). Digital scanning lightsheet microscopy (DSLM) for Drosophila whole brain functional imaging. Neural Imaging and Sensing 2025, 13303, 1330306.

  9. Alexander J White*, Belle Liu, Ming-Ju Hsieh, Kuo-an Wu, Chung-Chuan Lo* (2025). Hyper Flexible Neural Networks Rapidly Switch between Logic Operations in a Compact Four Neuron Circuit. npj Unconventional Computing, 2(1), 2.

  10. Belle Liu, Alexander James White*, Chung-Chuan Lo* (2025). Augmenting flexibility: mutual inhibition between inhibitory neurons expands functional diversity. iScience, 28(2).

  11. Rui Han*, Jun Zhang*, Guan-Xiong Huang, Ruo-Xi Yuan, Yun-Shan Lian, Meng-Ying Zhao, Yu-Yuan Lu, Hao Huang, Yu-Chen Wang, Yi-Jie Chen, Chung-Chuan Lo, Yi-Heng Tan (2025). The effects of blue light on locomotion and cognition in early adult Drosophila melanogaster. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, 343(4), 511-520.

  12. Rui Han*, Yi-Heng Tan, Chung-Chuan Lo* (2024). Attractiveness versus stickiness: Behavioural preferences of Drosophila melanogaster with competing visual stimuli. Journal of Insect Physiology, 159, 104716.

  13. Kai-Yi Hsu, Chi-Tin Shih*, Nan-Yow Chen*, Chung-Chuan Lo* (2024) LYNSU: automated 3D neuropil segmentation of fluorescent images for Drosophila brains. Frontiers in Neuroinformatics, 18, 1429670.

  14. Ning Chang, Yi-Chen Tsai, Wei J. Chen, Chung-Chuan Lo*, Hsiao-Han Chang* (2024). COVID-19 control measures unexpectedly increased the duration of stay at High Speed Rail stations during the first community outbreak in Taiwan. BMC Public Health, 24(1), 551.

  15. Alexander White, Chou P. Hung, Andre V. Harrison, Chung-Chuan Lo* (2023). Neuromorphic luminance-edge contextual preprocessing of naturally obscured targets. Proceedings of the 2023 International Conference on Neuromorphic Systems, 1-8.

  16. Ning Chang, Hsuan-Pei Huang and Chung-Chuan Lo* (2023). Global inhibition in head-direction neural circuits: a systematic comparison between connectome-based spiking neural circuit models. Journal of Comparative Physiology A, 209(4), 721-735.

  17. Anton P.J.Stampfl et al. (2023). SYNAPSE: An international roadmap to large brain imaging. Physics Reports, 999, 1-60.

  18. Alexander J. White, Chou P. Hung*, Chung-Chuan Lo* (2022). HDR luminance normalization via contextual facilitation in highly recurrent spiking neural networks. Unmanned Systems Technology XXIV SPIE, 12124, 137-149.

  19. Kuan-Lin Feng, Ju-Yun Weng, Chun-Chao Chen, Mohammed Bin Abubaker, Hsuan-Wen Lin, Ching-Che Charng, Chung-Chuan Lo, J. Steven de Belle, Tim Tully, Cheng-Chang Lien*, Ann-Shyn Chiang* (2021). Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila. iScience, 24(12), 103506.

  20. Yi-Shiuan Liu, Chih-Yu Yang, Ping-Fang Chiu, Hui-Chu Lin, Chung-Chuan Lo, Alan Szu-Han Lai, Chia-Chu Chang, Oscar Kuang-Sheng Lee* (2021). Machine Learning Analysis of Time-Dependent Features for Predicting Adverse Events During Hemodialysis Therapy: Model Development and Validation Study. Journal of Medical Internet Research, 23(9), e27098.

  21. Rui Han, Hsuan-Pei Huang, Wan-Ju Lee, Chia-Lung Chuang, Hung-Hsiu Yen, Wei-Tse Kao, Hui-Yun Chang, Chung-Chuan Lo* (2021). Coordination through inhibition: control of stabilizing and updating circuits in spatial orientation working memory. eNeuro, 8(5). [Selected as a cover art]

  22. Zuo-Wei Yeh, Chia-Hua Hsu, Chen-Fu Yeh, Wen-Chieh Wu, Cheng-Te Wang, Chung-Chuan Lo, Kea-Tiong Tang* (2021). POPPINS : A Population-Based Digital Spiking Neuromorphic Processor with Integer Quadratic Integrate-and-Fire Neurons. 2021 IEEE International Symposium on Circuits and Systems (ISCAS), 1-5.

  23. Patricia Parlevliet*, Andrey Kanaev, Chou P Hung, Andreas Schweiger, Frederick D Gregory, Ryad Benjamin Benosman, Guido C H E De Croon, Yoram Gutfreund, Chung-Chuan Lo, Cynthia F Moss (2021). Autonomous Flying with Neuromorphic Sensing. Frontiers in Neuroscience, 15, 672161. (PERSPECTIVE article)

  24. Hsin-Yu Wu, Wei-Tse Kao, Harrison Hao-Yu Ku, Cheng-Te Wang*, Chih-Cheng Hsieh, Ren-Shuo Liu, Kea-Tiong Tang and Chung-Chuan Lo* (2021). A Bio-Inspired Motion Detection Circuit for the Computation of Optical Flow: The Spatial-Temporal Filtering Reichardt Model. 2021 IEEE 3rd International Conference on Artificial Intelligence Circuits and Systems (AICAS), 1-4.

  25. Wen-Chieh Wu, Chen-Fu Yeh, Alexander James White, Cheng-Te Wang*, Zuo-Wei Yeh, Chih-Cheng Hsieh, Ren-Shuo Liu, Kea-Tiong Tang and Chung-Chuan Lo* (2021). Integer Quadratic Integrate-and-Fire (IQIF): A Neuron Model for Digital Neuromorphic Systems. 2021 IEEE 3rd International Conference on Artificial Intelligence Circuits and Systems (AICAS), 1-4.

  26. Chen-Zhi Su, Kuan-Ting Chou, Hsuan-Pei Huang, Chung-Chuan Lo*, Daw-Wei Wang* (2021). Identification of Neuronal Polarity by Node-Based Machine Learning. Neuroinformatics, 19(4), 669-684.

  27. Rui Han, Tzu-Min Wei, Szu-Chiao Tseng and Chung-Chuan Lo* (2021). Characterizing approach behavior of Drosophila melanogaster in Buridan's paradigm. PLoS One, 16(1), e0245990.

  28. Hao Chi, Lee Sun, Ren-Huei Shiu, Rui Han, Chien-Ping Hsieh, Tzu-Min Wei, Chung-Chuan Lo, Hui-Yun Chang and Tzu-Kang Sang* (2020). Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model. Scientific reports, 10(1), 13482.

  29. Kuo-Wei Kao and Chung-Chuang Lo* (2020). Short term depression, presynaptic inhibition and local neuron diversity play key functional roles in the insect antennal lobe. Journal of Computational Neuroscience, 48(2), 213-227.

  30. Chi-Tin Shih*#, Yen-Jen Lin#, Cheng-Te Wang, Ting-Yuan Wang, Chih-Chen Chen, Ta-Shun Su, Chung-Chuang Lo*, and Ann-Shyn Chiang* (2019). Diverse Community Structures in the Neuronal-level Connectome of the Drosophila Brain. Neuroinformatics, 18(2), 267-281. #: equal contribution

  31. Hung-Hsiu Yen, Rui Han and Chung-Chuan Lo* (2019). Quantification of Visual Fixation Behavior and Spatial Orientation Memory in Drosophila melanogaster. Frontiers in Behavioral Neuroscience, 13, 215.

  32. Huang-Yu Yao, Hsuan-Pei Huang, Yu-Chi Huang and Chung-Chuan Lo* (2019). Flyintel - a Platform for Robot Navigation based on a Brain-Inspired Spiking Neural Network. 2019 IEEE International Conference on Artificial Intelligence Circuits and Systems (AICAS), 219-220

  33. Yu-Chi Huang, Cheng-Te Wang, Ta-Shun Su, Kuo-Wei Kao, Yen-Jen Lin, Chao-Chun Chuang, Ann-Shyn Chiang and Chung-Chuan Lo* (2018). A Single-Cell Level and Connectome-Derived Computational Model of the Drosophila Brain. Frontiers in Neuroinformatics, 12, 99

  34. Ta-Shun Su, Wan-Ju Lee, Yu-Chi Huang, Cheng-Te Wang and Chung-Chuan Lo* (2017). Coupled symmetric and asymmetric circuits underlying spatial orientation in fruit flies. Nature Communications, 8(1), 139.

  35. Po-Yen Chang, Ta-Shun Su, Chi-Tin Shih* and Chung-Chuan Lo* (2017). The Topographical Mapping in Drosophila Central Complex Network and its Signal Routing. Frontiers in Neuroinformatics, 11, 26.

  36. Chung-Chuan Lo* and Ann-Shyn Chiang* (2016). Toward Whole-Body Connectomics. Journal of Neuroscience, 36(45), 11375-11383.

  37. Chung-Chuan Lo*, and Xiao-Jing Wang* (2016). Conflict Resolution as Near-Threshold Decision-Making: A Spiking Neural Circuit Model with Two-Stage Competition for Antisaccadic Task. PLOS Computational Biology, 12(8), e1005081.

  38. Cheng-Wei Li, Chung-Chuan Lo, and Bor-Sen Chen* (2016). Estimating Sensorimotor Mapping From Stimuli to Behaviors to Infer C. Elegans Movements by Neural Transmission Ability Through Connectome Databases. IEEE Transactions on Neural Networks and Learning Systems, 27(11), 2229-2241.

  39. Cheng-Wei Li, Chung-Chuan Lo, and Bor-Sen Chen* (2015). Robust Sensorimotor Control of Human Arm Model under State-Dependent Noises, Control-Dependent Noises and Additive Noises. Neurocomputing, 167, 61-75.

  40. Chung-Chuan Lo# , Cheng-Te Wang and Xiao-Jing Wang*# (2015). Speed-accuracy tradeoff by a control signal with balanced excitation and inhibition. Journal of Neurophysiolog,y 114(1), 650-661. (#: equal contribution)

  41. Chi-Tin Shih*, Olaf Sporns, Shou-Li Yuan, Ta-Shun Su, Yen-Jen Lin, Chao-Chun Chuang, Ting-Yuan Wang, Chung-Chuan Lo, Ralph J. Greenspan, and Ann-Shyn Chiang* (2015). Connectomics-Based Analysis of Information Flow in the Drosophila Brain. Current Biology, 25(10), 1249-1258.

  42. Yi-Hsuan Lee, Yen-Nan Lin, Chao-Chun Chuang and Chung-Chuan Lo* (2014). SPIN: A Method of Skeleton-based Polarity Identification for Neurons. Neurinformatics, 12(3), 487-507.

  43. Yen-Nan Lin, Po-Yen Chang, Pao-Yueh Hsiao and Chung-Chuan Lo* (2014). Polarity-specific high-level information propagation in neural networks. Frontiers in Neuroinformatics, 8, 27.

  44. Pao-Yueh Hsiao and Chung-Chuan Lo* (2013). A Plastic Cortico-Striatal Circuit Model of Adaptation in Perceptual Decision. Frontiers in Computational Neuroscience, 7, 178.

  45. Chung-Chuan Lo, Ronny P. Bartsch and Plamen Ch. Ivanov* (2013). Asymmetry and basic pathways in sleep-stage transitions. Europhysics Letters, 102(1), 10008.

  46. Cheng-Te Wang, Chung-Ting Lee, Xiao-Jing Wang, Chung-Chuan Lo* (2013). Top-Down Modulation on Perceptual Decision with Balanced Inhibition through Feedforward and Feedback Inhibitory Neurons. PLoS One, 8(4), e62379.

  47. Ying-Zu Huang, Chin-Song Lu, John C. Rothwell, Chung-Chuan Lo, Wen-Li Chuang, Yi-Hsin Weng, Szu-Chia Lai, Rou-Shayn Chen* (2012) Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex. PLoS One, 7, e47574.

  48. Chung-Chuan Lo, Leanne Boucher, Martin Pare, Jeffery D. Schall and Xiao-Jing Wang* (2009). Proactive inhibitory control and attractor dynamics in countermanding action: a spiking neural circuit model. Journal of Neuroscience, 29(28), 9059-9071.

  49. Chung-Chuan Lo and Xiao-Jing Wang* (2006). Cortico-basal ganglia circuit mechanism for a decision threshold in reaction time tasks. Nature Neuroscience, 9(7), 956-963.

  50. Chung-Chuan Lo, Thomas Chou, Thomas Penzel, Thomas E. Scammell, Robert E. Strecker, H. Eugene Stanley, and Plamen Ch. Ivanov* (2004). Common scale-invariant pattern of sleep-wake transitions across mammalian species. Proceedings of the National Academy of Sciences, 101(50), 17545-17548.

  51. Thomas Penzel, Jan W. Kantelhardt, Chung-Chuan Lo, Karlheinz Voigt and Claus Vogelmeier* (2003). Dynamics of Heart Rate and Sleep Stages in Normals and Patients with Sleep Apnea. Neuropsychopharmacology, 28(1), S48-S53.

  52. Chung-Chuan Lo, L. A. Nunes Amaral, S. Havlin, Plamen. Ch. Ivanov, Thomas Penzel, J.-H. Peter and H. Eugene Stanley* (2002). Dynamics of sleep-wake transitions during sleep. Europhysics Letters, 57(5), 625.

  53. Plamen. Ch. Ivanov* and Chung-Chuan Lo (2002). Stochastic Approaches to Modeling of Physiological Rhythms. Modeling Biomedical signals, 28-50.

  54. Chung-Chuan Lo, Jui-Hung Hsu, You-Cheng Sheu, Chein-Min Chiang, Wen-guey Wu, Wunshain Fann* and Pei-Hsi Tsao (1998). Effect of D57N mutation on membrane activity and molecular unfolding of cobra cardiotoxin. Biophysical Journal, 75(5), 2382-2388.

Other Publications

  1. 電腦與人腦：現代電腦架構之父馮紐曼的腦科學講義 -- 中文版導讀 (貓頭鷹出版社，出版日期：2021-05-06)

  2. 昆蟲動態視覺與其仿生應用，<電腦與通訊> 2020年12月號184期

  3. 小腦袋大數據-大腦圖譜研究計畫 <科學月刊> 2018 三月號

Media Coverage and Interviews

  1. Nature News: Gigantic map of fly brain is a first for a complex animal. (Commentary on Winding, M. et al. Science 379, eadd9330) (Mar. 10, 2023)
  2. TaiwanPlus: Bug-Inspired Tech Improves Drone Capabilities (Feb. 08, 2023)
  3. 聯合報：清華生科、電機團隊聯手 研發仿生物視覺技術(Jan. 27, 2022)
    Other media sources: 自由日報、鏡週刊、蘋果新聞網
  4. Businesswire: NTHU Research Team Teaches Drone to Fly Like an Insect (2020)
    清華研發仿視神經AI晶片 讓無人機學果蠅飛行 Central News Agency (中央社), February 2, 2020. Other media sources: 聯合報、三立
  5. Gene Ng, 果蠅腦中的神經元，如何跟機械的指南車一樣可以指出固定方向？ published September 29, 2017. Inside (http://www.inside.com.tw/)
  6. Benedicte Ballanger, Top-down control of saccades as part of a generalized model of proactive inhibitory control Journal of Neurophysiology published 26 August 2009, 10.1152/jn.00717.2009
  7. Roozbeh Kiani, Timothy D Hanks & Michael N Shadlen. When is enough enough? Nature Neuroscience 9, 681-683 (2006).
  8. Taylor McNeil, Bring on the Sandman. Bostonia. Summer 2002.
    (http://www.bu.edu/alumni/bostonia/2002/summer/explorations/sleep/index.html)
  9. Michael Brooks, Feature: Snooze Control. New Scientist p. 173, 38-40, Feb. 23, 2002.
  10. "Tired? Well, you woke up 35 times last night", The Daily Mail, p. 35, Feb. 21, 2002.
  11. "Sleep well last night? You woke up 37 times", The Mirror, Feb. 21, 2002.
  12. Complex Digest issue 51, Dec. 19 2001. (http://www.comdig.de/ComDig01-51/#12)