LOCUS       1345872        81 aa                              01-OCT-1996
DEFINITION  CYTOTOXIN 3 PRECURSOR (CARDIOTOXIN ANALOGUE III) (CTX III)
            (CARDIOTOXIN C-10) (CYTOTOXIN IV).
ACCESSION   1345872
PID         g1345872
DBSOURCE    SWISS-PROT: locus CX3_NAJAT, accession P01444
            class: standard.
            created: Jul 21, 1986.
            sequence updated: Feb 1, 1996.
            annotation updated: Oct 1, 1996.
            xrefs: gi: 1054810, gi: 1054811, gi: 1326090, gi: 1326091, gi:
            69484, gi: 85975
            xrefs (non-sequence databases): PROSITE PS00272
KEYWORDS    VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE;
            SIGNAL.
SOURCE      monocled cobra.
  ORGANISM  Naja kaouthia
            Eukaryotae; Metazoa; Chordata; Vertebrata; Lepidosauria; Squamata;
            Scleroglossa; Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
REFERENCE   1  (residues 1 to 81)
  AUTHORS   CHANG,L., LIN,J. and WU,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-SEP-1995) TO EMBL/GENBANK/DDBJ DATA BANKS
  REMARK    SEQUENCE FROM N.A.
            SPECIES=N.ATRA; TISSUE=VENOM GLAND
REFERENCE   2  (residues 1 to 81)
  AUTHORS   CHU,R.C. and YANG,C.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-DEC-1995) TO EMBL/GENBANK/DDBJ DATA BANKS
  REMARK    SEQUENCE FROM N.A.
            SPECIES=N.ATRA; TISSUE=VENOM GLAND
REFERENCE   3  (residues 1 to 81)
  AUTHORS   Hayashi,K., Takechi,M., Kaneda,N. and Sasaki,T.
  TITLE     Amino acid sequence of cardiotoxin from the venom of Naja naja atra
  JOURNAL   FEBS Lett. 66 (2), 210-214 (1976)
  MEDLINE   76257817
  REMARK    SEQUENCE OF 22-81, AND REVISION.
            SPECIES=N.ATRA; TISSUE=VENOM
REFERENCE   4  (residues 1 to 81)
  AUTHORS   Narita,K. and Lee,C.Y.
  TITLE     The amino acid sequence of cardiotoxin from Formosan cobra (Naja
            naja atra) venom
  JOURNAL   Biochem. Biophys. Res. Commun. 41 (2), 339-343 (1970)
  MEDLINE   71211413
  REMARK    SEQUENCE OF 22-81.
            SPECIES=N.ATRA; TISSUE=VENOM
REFERENCE   5  (residues 1 to 81)
  AUTHORS   Chiou,S.H., Lin,W.W. and Chang,W.P.
  TITLE     Sequence characterization of venom toxins from Thailand cobra
  JOURNAL   Int. J. Pept. Protein Res. 34 (2), 148-152 (1989)
  MEDLINE   90035789
  REMARK    SEQUENCE OF 22-81.
            SPECIES=N.N.KAOUTHIA; TISSUE=VENOM
REFERENCE   6  (residues 1 to 81)
  AUTHORS   Ohkura,K., Inoue,S., Ikeda,K. and Hayashi,K.
  TITLE     Amino-acid sequences of four cytotoxins (cytotoxins I, II, III and
            IV) purified from the venom of the Thailand cobra, Naja naja
            siamensis
  JOURNAL   Biochim. Biophys. Acta 954 (2), 148-153 (1988)
  MEDLINE   88209578
  REMARK    SEQUENCE OF 22-81.
            SPECIES=N.N.KAOUTHIA; TISSUE=VENOM
REFERENCE   7  (residues 1 to 81)
  AUTHORS   Bhaskaran,R., Huang,C.C., Chang,D.K. and Yu,C.
  TITLE     Cardiotoxin III from the Taiwan cobra (Naja naja atra).
            Determination of structure in solution and comparison with short
            neurotoxins
  JOURNAL   J. Mol. Biol. 235 (4), 1291-1301 (1994)
  MEDLINE   94141922
  REMARK    STRUCTURE BY NMR.
COMMENT     LD(50) IS 1.48 MG/KG BY INTRAPERITONEAL INJECTION.
            [CAUTION] THIS TOXIN IS KNOWN AS CYTOTOXIN 3 IN N.ATRA AND
            CYTOTOXIN IV IN N.N.KAOUTHIA.
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Naja kaouthia"
                     /db_xref="taxon:8649"
     Protein         1..81
                     /product="CYTOTOXIN 3 PRECURSOR"
     Region          1..21
                     /region_name="Signal"
     Region          22..81
                     /note="CARDIOTOXIN 3."
                     /region_name="Mature chain"
     Bond            bond(24,42)
                     /bond_type="disulfide"
     Bond            bond(35,59)
                     /bond_type="disulfide"
     Region          59
                     /note="C -> R (IN REF. 1)."
                     /region_name="Conflict"
     Bond            bond(63,74)
                     /bond_type="disulfide"
     Bond            bond(75,80)
                     /bond_type="disulfide"
ORIGIN      
        1 mktllltlvv vtivcldlgy tlkcnklvpl fyktcpagkn lcykmfmvat pkvpvkrgci
       61 dvcpkssllv kyvccntdrc n
//

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