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ProstaglandinX¦¨¦É®A¡Ñ¥arachidonio acidñ®Æ¤Ü¦PGG2ºªB¨JƤ¤A¡Ý»n­COX (Cyclooxygen)ºªÊ¶Æ¤(Fig 1)A¡NSAIDsY§O¬í§î¨ProstaglandinºªX¦¨¦ñ®Æ¤  COX (Fig2)A¡i¶Ó¦°­C§ProstaglandinºªÆ¼q¶A¡F¹ì¨Ñ¸ö¼íÂhµºª@§Î¥C¡ý¦NSAIDsO¬”D«ï¿Ü¾Ê©”a¦í§î¨ProstaglandinA¡£¤È¶í§î¨F¤oµ¢ª¡³ì¦ºªProstaglandinA¡P¦É®]¤í§î¨F¤¿¥`±Ó²M­º¤ºªProstaglandinA¡z¸G­D¹º¤ì­»¥ã¨³¦O«@Å@§Î¥ºªProstaglandinA¡Q³NSAIDs£¤À¤C«õ¬m¨Õ¥a¦í§î¨A¡Ï¨o±AªÎ¥NSAIDs£°F¤³À³¦ºªøÀÄ®~¥A¡ÙÁþªa±F¤Ë¶z¸G­ºªÆ°@§Î¥C¡ 
























     ProstaglandinºªX¦¨¦ñ®Æ¤  ³¦â¨ØºG¡COX1(mRNA 2.8kb)ΤCOX2(mRNA 4kb)A¡COX1ºªmRNAh¦s¦b¦ó©¿¥`±ºªÕ²´Â¤¤A¡]¥A¬£¸¡³B¡ß¤¦ÅB¡Çµ¦ÅB¡Íª....¥µ¥µA¡z¸G­D¹º¤ºªÆ¼q¶×¤h¦C¡MµÓ¦COX2ºªmRNAo«¥·Ö¤s¦b¦ó©o³Ç¨¿¥`±ºªÕ²´Â¤¤A¡Ï¤Ó¦h¦À¤G§ó©oµ¢ªºªÕ²´Âº¤A¡p¦¹¦ºªÀ¤G§A¡£´Ñ¨F¤ï§}¨NSAIDsºªkªh«A¡Y­O¬Äëªi¥H¥ï¿Ü¾Ê©a¦í§î¨COX2Ó¦£¤í§î¨COXA¡h«¹¦ÄÃN±i¥H¥î´´»oµ¢ªºªg¯¬ªA¡B¥£¤v¼TÅ¿¥`±Õ²´Â¤¤Prostaglandinºª@§Î¥C¡

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1829~¦LerousÛ¦ð¾Ö¥¤¤À¤÷ÂX¥salicin¨¦À¤ã¨³¦Ñ¸ö¼ºª@§Î¥C¡g¸L¹£¤_ºªÕ¸çÅA¡1899~¦Bayer£´X¥F¤Aspirin㨳¦Ñ¸ö¼íÂhµÜ§oµ¢ªÜ«n¦ºªøÀÄ®C¡”a”íªÜ¥acetylA¡”spirin”íªÜ¥SpiraeaA¡°¬£´Ò·ºªÓ´«ªW¦ÙºC¡
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(1)COX-1 ID50 = 5.4uM
  COX-2 ID50 = 0.008uM
  selectivity =675:1

									(2)COX-1 ID50 > 100uM
									  COX-2 ID50 = 0.004uM
(1) n=0	(2) n=1 (3) n=2 (4)n=3            selectivity >25000:1

(3)COX-1 ID50 > 100uM				(4)COX-1 ID50 > 100uM
  COX-2 ID50 = 0.062uM				  COX-2 ID50 >100uM
  selectivity >1612:1					  no selectivity 

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									(5)R1=F R2=CH3
									(6)R1=F R2=CH2F
									(7)R1=F R2=CF3
									(8)R1=F R2=C2H5

Ñ¥ó©ôÀ³¥m²U¤ºªß¥éŲµcºCOX-2 activity 5 > 6 > 7 > 8 










(9)COX-1 ID50 > 18.3uM		            (10)COX-1 ID50 = 3.68uM
  COX-2 ID50 = 0.15uM    				   COX-2 ID50 = 0.52uM
  selectivity >âFZ\^`bdfhjìZ¶¸üþ@"öøÖ"Ø"Ú"Ü"Þ"à"â"ä"æ"è"ê"ì"î"ð"ò"ô"ö"ø"ãp hãp {ãp hãp hãp hãp hãp hãp hãp hãp hãp hãp hãp háp háp mááp mÝp mÝp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp m(48©. 'P@ñÿ¤º¤åa	A@òÿ¡¹w³]¬q¸¨¦r«¬	 COX2ºªoµ{²A¡O¥H¤D«`±åÅß³I¡i¥¡»O¬Ï°À¤F¤¿¥`±Õ²´ÂP»oµ¢ªÕ²´ÂºªnA¡Ñ¸M¨F¤@¤ñ¬”ÄÔ´¥½ÂF¤ã¾î² ”n” ºª~µÒ¹C¡


















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rditog$yx¥WÆ NO.1 Macro Virusdogë€gê€ians$gê€g€icondog+€y¥®P¶A§ªµï¹F¤,ö«T½w©N´i§D¶A§Q·¾ªD¹ºª....rdoyx¥WÆ NO.1 Macro Virusdog-dogS€dog®s!yÓ²ú©éÅs"ls$ls(lRdog,€dog€yó¦×¿¨¥°¶f¯r¬H¡dog€dog,€dog€yªµ×®:dogI€ldog€yÚ§N´O¬.....dog€dog€dogI€ldog®s!yÓ²ú©éÅs"ls$ls(lRdog,€dog€y	p¦ó¦w¹¾¨¨¥°¶f¯r¬H¡dog€dog,€dog€yªµ×®:dogI€ldog€y	£¤n­Ý¬Ú§.....do*iexitdo do#ijl$ldog,€dog-do&ijRdogS€dog®s!yÓ²ú©éÅs"ls$ls(lRdog€y¨¥°¶f¯r¬do*itrydoddo"doddinorg·€ldinorldR#ikkl$inordog¸€ikklyAutoOpendoitldodo&ikkdodRddifile$g%€difilem$ifile$y	:AutoOpend2300:1						   selectivity =7.07:1
									








(11)COX-1 ID50 = 4.21uM                 (11)COX-1 ID50 = 0.027uM
   COX-2 ID50 = 0.007uM				       COX-2 ID50 = 0.003uM
   selectivity >601:1						   selectivity 9:1

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(1)COX-1 ID50 = 5.4uM
  COX-2 ID50 = 0.008uM
  selectivity =675:1

									(2)COX-1 ID50 > 100uM
									  COX-2 ID50 = 0.004uM
(1) n=0	(2) n=1 (3) n=2 (4)n=3            selectivity >25000:1

(3)COX-1 ID50 > 100uM				(4)COX-1 ID50 > 100uM
  COX-2 ID50 = 0.062uM				  COX-2 ID50 >100uM
  selectivity >1612:1					  no selectivity 

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									(5)R1=F R2=CH3
									(6)R1=F R2=CH2F
									(7)R1=F R2=CF3
									(8)R1=F R2=C2H5

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(9)COX-1 ID50 > 18.3uM		            (10)COX-1 ID50 = 3.68uM
  COX-2 ID50 = 0.15uM    				   COX-2 ID50 = 0.52uM
  selectivity >âFZ\^`bdfhjìZ¶¸üþ@"öøÖ"Ø"Ú"Ü"Þ"à"â"ä"æ"è"ê"ì"î"ð"ò"ô"ö"ø"ãp hãp {ãp hãp hãp hãp hãp hãp hãp hãp hãp hãp hãp háp háp mááp mÝp mÝp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp máp m(48©. 'P@ñÿ¤º¤åa	A@òÿ¡¹w³]¬q¸¨¦r«¬	 COX2ºªoµ{²A¡O¥H¤D«`±åÅß³I¡i¥¡»O¬Ï°À¤F¤¿¥`±Õ²´ÂP»oµ¢ªÕ²´ÂºªnA¡Ñ¸M¨F¤@¤ñ¬”ÄÔ´¥½ÂF¤ã¾î² ”n” ºª~µÒ¹C¡


















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