1999/4/28 Jiun-Ming Wu, g874261
1. C2 domains are calcium ion and/or phospholipid-binding
domains ;
they occur in a wide range
of eukaryotic signaling proteins, and are
involved in a large range
of processes including lipid-second messenger
generation, activation of
GTPase and phosphorylation control. And £\-
toxin has PLC and PKC
activity.
2. Two extremely expose hydrophobic residues Trp
214 and Phe 334,
indicates the approximate
position of a membrane binding surface.
3. Haemolytic activity
*
PC-PLC has no haemolytic activity.
This protein lacks the C2-like domain.
Sequence identity with the £\-toxin N-terminal domain is low
(16%) in the putative membrane binding loop.
4. An addition C-terminal domain can confer toxicity
* membrane binding
* PKC activity
5. Iraq chemical warfare
* antitoxin development