Function/Membrane-protein binding 

£\-toxin use its C2-like domain fold to bind membrane in a manner
     similar to those of the proteins whose function it dispurts.
 
          ¡C PKC (first example of a C2-like domain)
                       ==> biological function of £\-toxin leading to gas gangrene
 
          ¡C Lipoxygenase (HA5L, 15LO, 1LO)
                       ==> not Ca2+-dependent, not the lipid binding manner!
 
 
Membrane binding

     Forming a complex with calcium and phospholipid headgroups.
         Calcium ions mediate interactions with the phospholipid headgroups,
         creating a charge-charge interaction.

     Burying highly exposed large hydrophobic residues.
         The plane defined by two extremely expose hydrophobic residues
         Trp 214 and Phe 334 , indicates the approximate position
         of a membrane binding surface.

     A highly hydrophobic, disordered surface loop (residues 84-88).
              a. Phospholipid taigroup binding.
              b. Communicating calcium and/or membrane-binding to the active site,
                  thereby initiating any conformational changes required to activate
                  enzyme.