How stable is the SH3 Domain from Bruton's tyrosine kinase ?
¡ó	Small protein modules (55-70 residues)
¡ó	No disulfide bonds
¡ó	Beta-barrel structure
What is the peptide binding specificity of the SH3 domain from Bruton's tyrosine kinase ?
¡ó	Two binding classes: X1pX2PpX3P and X3'PpX2'PpX1'
¡ó	The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds to the SH3 domain of BTK
¡ó	A SH3-binding site conserved in Bruton's tyrosine kinase mediates specific protein interaction in vivo and in vitro