Publications

Chang, C. C. and Huang, P. C. in preparation. 
Cysteine contribution to binding site preference for Zn/Cd in the b-domain of metallothionein.. 

Huang, M. C., Pan, P. K., Zeng, T. F., Chen, N. C., Peng, J. Y. and Huang, P. C. in preparation. 
Multiple isoforms of metallothionein are expressed in the porcine liver. 

Chen, W. M., Hsieh, H. M.,  Liu, W.K., Chang, A. and Huang, P. C. in preparation. 
Type 2 rice metallothionein-like genomic DNA with two introns. 

Hsieh, H.M. and Huang, P.C. in preparation. 
Type 1 rice metallothionein-like gene: its putative upstream cis-elements, and promoter activity as affected by its intron. 

Chang, C. C. and Huang, P. C. Protein Engineering 9, 1165-1172. 
Semi-empirical simulation of Zn/Cd binding site preference in the metal binding domain of mammalian metallothionein. 

Hsieh, H. M.,  Liu, W.K., Chang, A. and Huang, P. C. Plant Mol. Biol. 32, 525-529 (1996).
RNA expression patterns of a type 2 metallothionein-like gene from rice.

Hsieh, H.M., Liu, W.K. and Huang, P.C. Plant Mol. Biol. 28, 381-389 (1995). 
A noval stress-inducible metallothionein-like gene from rice. 

Yeh, S.C.., Hsieh, H.M., and Huang, P.C. DNA sequence/J. Sequencing and Mapping 5,141-144 (1994). 
Transcripts of metallothionein genes in Arabidopsis thaliana. 

Pan, P.K., Hou, F.Y., Cody, C., and Huang, P.C. Biochem. Biophys. Res. Comm. 202,621-628(1994). 
Substitution of glutamic acids for the conserved lysines in the alpha domain affects metal binding in both the alpha and beta domains of mammalian metallothionein. 

Cody,C., and Huang, P.C. Biochemistry 32,5127-5131 (1993) . 
Metallothionein detoxification function is impaired by replacement of both conserved lysines with glutamines inthe hinge between the two domains. 

Hidalgo, J., Rhee, S.J., Huang, P.C. and Garvey, J.J. Hormone Metabolic Res. 24, 233-236 (1992).
Physiological role of glucocorticoids on the regulation of rat liver metallothionein synthesis. 

Hung, S., Yu, C., Chou, T., Huang, P.C. and Lin, L.Y. Biochem. Biophys. Acta 1090,255-228 (1991).
Molecular cloning of Chinese hamster metallotnionein II genes and its 5` flanking region. 

Cismowski, M., Narula, S.S., Armitage, I. , Chernaik, M. and Huang, P.C. J. Biol. Chem. 266, 24390-24397 (1991) 
Mutation of invariant cysteines of Chinese hamaster metallothionein alters metal binding capacity, cadmium resistance and 113 Cd NMR spectrum.

 Cismowski, M., and Huang, P.C. Biochemistry 30, 6626-6632 (1991). 
The effect of cysteine replacements at position 13 and 50 on metallothionein structure. 

Chernaik, M. and Huang P.C. Proc. Natl. Acad. Sci. USA 88, 3024-3028 (1991).
Differential effects of cysteine to serine substitutions in metallothionein on cadmium resistance. 

Rhee, I.K., Lee, K.S. and Huang, P.C., Protein Engineering 3. 205-213 (1990)
Metallothionein with interdomain hinges expanded by insertion mutagenesis.    

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