Design
of a Heparin-binding peptide
-
Heparin
and related glycosaminoglycans (GAGs) - components
of the extracellular matrix, participants in signal transduction pathways
-
Many proteins bind specifically
to GAGs and perform an important role in inflammation,
cell
proliferation and blood coagulation processes
-
Heparin polymer is generated
from disaccharide repeat units consisting
of D-glucosamine (GlcN)
and L-iduronic acid (IdoA)
joined by a1-4
linkages.
-
Successive disaccharides are
related by a twofold screw operation
-
generated by a rotation
of approximately 180°
-
coupled with a translation
of 8.0 - 8.7 Å
-
Heparin-binding
protein
-
GAGs
DataBase
-
PDB model
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