Yuan and Clarke at Johns Hopkins have tried to transform the coiled structure into a sheet.

"They think b-sheet was a very stable structure"

Failure !

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Regarn transformed a primarily b-sheet protein into a native-like, stable, four-helix bunde protein whileretaining 50% of the original sequence

"They think they know more about helix formation and helix-helix interaction"

Succeed !

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Not all residues play an equally important role in specifying a particular fold

For Genomics researchers working with the 30% standard - there are times we will be fooled