Specific transcription factors belong to a few families

  • The coiled-coil structure of the leucine zipper motif is not the only way to form dimers of transcription factors.



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  • The HLH motif is involved in heterodimer and homodimer association
  • Form a four-helix bundle structure
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  • b/HLH family of transcription factor - MyoD
  • The half-site spacing is invariant in the b/HLH family, in contrast to the b/zip family

    • - the small four helix bundle locks the basic regions in position and prevents them spreding apart
  • The a-helical basic region binds in the major groove of DNA with the consensus DNA sequence 5'-CANNTG-3'


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