Yeast transcription factor GAL4 contains a binuclear zinc cluster in its DNA-binding domain
- subfamily of zinc-containing motifs from yeast and fungi
- activates transcription of genes required for break down of the sugar galactose and melibiose
- large protein, 881 AA
- DNA binding region 1-49
- Dimerization region 50-94
- Acidic activating regions 94-106, 148-196, 768-881
The zinc cluster regions of GAL4 bind at the two ends of the enhancer element
The linker region also contributes to DNA binding
- responsible for specificity
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