Michelle L. Lamb

Phone: (415) 476-5873
Fax: (415) 502-1411

Education:

Yale University, Chemistry, Ph.D. 1998
"Computational Investigations of Protein-Ligand Binding: FK506 Binding Protein"
Advisor: Professor William L. Jorgensen

Drew University , Chemistry and (Applied) Mathematics, B. A. 1991
Internship, Eli Lilly and Company , Computational Chemistry, 1990

Publications:

Michelle L. Lamb, Julian Tirado-Rives and William L. Jorgensen, "Estimation of Binding Affinity for FKBP12 Inhibitors by a Linear Response Method." Bioorg. Med. Chem., 1999, 7, 851-860.

R.H. Smith, Jr., W.L. Jorgensen, J. Tirado-Rives, M.L. Lamb, P.A.J. Janssen; C.J. Michejda, M.B. Kroeger Smith. "Prediction of Binding Affinities for TIBO Inhibitors of HIV-1 Reverse Transcriptase Using Monte Carlo Simulations in a Linear Response Method." J. Med. Chem., 1998, 41, 5272-5286.

Michelle L. Lamb and William L. Jorgensen, "Investigations of Neurotrophic Inhibitors of FK506 Binding Protein via Monte Carlo Simulations", J. Med. Chem., 1998, 41, 3928-3939.

Michelle L. Lamb and William L. Jorgensen, "Computational Approaches to Molecular Recognition", Curr. Opin. Chem. Biol., 1997, 1, 449-457.

William L. Jorgensen, Erin M. Duffy, Jonathan W. Essex, Daniel L. Severance, James F. Blake, Deborah K. Jones-Hertzog, Michelle L. Lamb, and Julian Tirado-Rives. "Approaches to Protein-Ligand Binding from Computer Simulations." In Biomolecular Structure and Dynamics: Recent Experimental and Theoretical Advances; Vergoten, G. and Theophanides, T., Eds.; Kluwer Academic Publishers: The Netherlands, 1997; pp. 21-34.

William L. Jorgensen, Wolfgang Damm, Antonio Frontera, and Michelle L. Lamb. "Molecular Recognition of Carbohydrates: Interaction of Diols with Acetate Ion." In Physical Supramolecular Chemistry; Echegoyen, L. and Kaifer, A. E., Eds.; Kluwer Academic Publishers: The Netherlands, 1996; pp 115-126.

John S. Ward, Leander Merritt, V. J. Klimkowski, M. L. Lamb, C. H. Mitch, F. P. Bymaster, B. Sawyer, H. E. Shannon, Preben H. Olesen, Tage Honore, Malcolm J. Sheardown, and Per Sauerberg. "Novel Functional M1 Selective Muscarinic Agonists. 2. Synthesis and Structure-Activity Relationships of 3-Pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a Molecular Model for the M1 Pharmacophore." J. Med. Chem., 1992, 35, 4011-4019.