| Part1 |
| (a) p53 gene is located between chromosome 17p13.2~17p12(•i®£§U§G±ifigures) |
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| (b)p53¶Ï©Û§HÅÈ™º²ƒ§Q§C±¯¨V¶‚ÅȧW |
| (c)•¶™ºLocus ID¨O17p13.1 |
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(d) SELECTED MODEL ORGANISM PROTEIN SIMILARITIES
H. sapiens: PID:g189479 - p53 cellular tumor antigen 100 % / 392 aa
M. musculus: PID:g2961247 - tumor suppressor p53 77 % / 395 aa
R. norvegicus: SP:P10361 - P53_RAT CELLULAR TUMOR ANTIGEN P53 77 % /
392 aa
You can see more detail in this page
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| (e) |
(f) MEEPHSDLSIEPPLSQETFSDLWKLLPENNVLSDSLSPPMDHLLLSPEEVASWLGENPDGDGHVSAAPVS
EAPTSAGPALVAPAPATSWPLSSSVPSHKPYRGSYGFEVHFLKSGTAKSVTCTYSPGLNKLFCQLAKTCP VQVWVESPPPPGTRVRALAIYKKSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLHAEYVDDRTTF
RHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGKLLGRDSFEVRVCACPGRDR RTEEENFRKKGGLCPEPTPGNIKRALPTSTSSSPQPKKKPLDAEYFTLKIRGRKNFEILREINEALEFKD
AQTEKEPGESRPHSSYPKSKKGQSTSCHKKLMFKREGLDSD
you can see more detail in this page |
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(g)
p53 tetramerization domain's PDB ID is 1AIE
p53 core domain's PDB ID is 1TsR
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| part 2 |
| (1)catalytic triad could be ser38(red), his39(yellow), and
asp36(green) in the figure. |
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| (2) the DNA binding domain could be between the two handlike objects. |
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