Jurassic 九十學年度下

Molecular Biology by 張大慈' 楊嘉玲' 黃海美教授

一,課程說明本課程為分子生物學一（88上LS4401）之延續課程，未曾修過LS4401者，須經由授課老師同意才能選修本課程。本課程共分三部份，第一部份涵蓋基因轉錄後之修飾機制，以及利用酵母菌研究真核基因的功能。第二部份涵蓋基因轉譯為蛋白質之機制，以及分子的演化。第三部份涵蓋訊號傳遞分子與癌基因、抑癌基因的作用功能，細胞週期、細胞生長、細胞死亡以及胚胎發育之分子調控機制。

二,指定用書
1. Molecular Biology by R. F. Weaver in 1999, Publisher: WCB/McGraw Hill
2. Molecular Cell Biology, 4th Ed (2000) Lodish, Berk, Zipursky, Matsudaira,
Baltimore, Darnell, Publisher: W. H. Freeman and Company.

三,參考書籍
1. Recombinant DNA by Watson et al. (1992), Publisher: Scientific American Books
2. Alberts, B., Bray, D., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter,
P. (1998) Essential Cell Biology: An Introduction to the Molecular Biology
of the Cell. Publisher: Garland Publishing, Inc.

四,教學方式
第一和第二部份教材以指定用書為主(3/4)，以參考書籍：Recombinant DNA為要(1/4)。
分子生物二Part III使用 Molecular Cell Biology, 4th Ed (2000) Lodish, Berk, Zipursky, Matsudaira, Baltimore, Darnell, Publisher: W. H. Freeman and Company.
生科系圖書館備有二本供修課同學借閱，可向圖書館何小姐登記借閱。

五,教學進度
Part VI Translation
(Week 1-5) Lecturer: Da-Tz Chang

Week 1 (02/20,02/23) Chap 17 The mechanism of translation I: initiation
Week 2 (02/27,03/02) Chap 18 The mechanism of translation II:
elongation and termination
Week 3 (03/06)
Week 4 (03/13,03/16) Chap 19 Ribosomes and transfer RNA
Week 5 (03/20,03/23) X Molecular evolution
Week 6 (03/27,03/30) Evaluation

Part VII. DNA Replication, recombination and transposition
(Week 6-11) Lecturer: Haimei Huang

Week 6 (03/30) Chap 20 DNA Replication I:basic mechanism and Enzymology
Week 7 Spring Break
Week 8 (4/10,4/13) Chap 21 DNA Replication II: Detailed mechanism
Week 9 (4/17,4/20) Chap 21 DNA Replication II: Detailed mechanism
Week 10 (4/24,4/27) Chap 22 Recombination and transposition
Week 11 (5/1,5/4) Chap 22 Recombination and transposition
Week 12 (05/11) Evaluation

Part III (Week 12-17)
Lecturer: Jia-Ling Yang
Text Book: Molecular Cell Biology, 4th Ed (2000) Lodish, Berk, Zipursky, Matsudaira, Baltimore, Darnell, Publisher: W. H. Freeman and Company.

(Week 12-13)Regulation of the Eukaryotic Cell Cycle
5/8 Chap. 13.1-13.3 (p. 495-510)
5/11,15 Chap. 13.4-13.7 (p. 510-533)
(Week 13-14)Microtubule Dynamics and Motor Proteins during Mitosis
5/18 Chap. 19.1-19.2 (p. 795-809)
5/22 Chap. 19.3; 19.5 (p.809-817; p. 823-836)
5/25 Exam I (1-3pm)
(Week 15) Cell-to-Cell Signaling
5/29 Chap. 20.1-20.3 (p.848-871)
6/1 Chap. 20.4-20.8 (p.871-906)
(Week 16-17)Molecular Oncology
6/5 Chap. 24.1 (p.1054-1063)
6/8,12 Chap. 24.2-24.5 (p.1064-1082)
(Week 17)Gene Control and Cell Interactions in Development
6/15 Chap. 14.3 (p. 553-571)
Chap. 23.1 (p. 1003-1013)
Chap. 23.2-23.3; 23.8 (P. 1013-1021; 1044-1051)
6/19 Exam II (1-3pm)

六,成績考核
The grade is an average of three parts.

七,講義位址
參考書籍置於生科系圖書館，學生可向圖書館小姐借閱。
講義將於每次上課前發給修課學生。