Search genes associated with colon cancer in human genome


MLH1 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS.

1. How many hits will you get if you search genes associated with colon cancer in human genome?

answer: 17hits (link)


2. How many loci will you find if you search locus link for human in Genbank?

answer: 21 loci (link)


3. Give the locus ID and position of MLH1.

answer: locus ID : 4292 ; position : 3p21.3 (link)


4. Find the %ID of nucleotide sequence for its possible orthologs in mouse.

answer: 89.3% (link)


5. Find the total number of mutations of MLH1 reported in human gene mutation database.

answer: 147 (link)


6. Give the DNA sequence of MLH1.

answer : link


7. Give the DNA sequence of E. coli mismatch repair gene mutS.

answer: link