Search genes associated with colon cancer in human genome
MLH1 was identified as a locus frequently mutated in hereditary
nonpolyposis colon cancer (HNPCC).
When cloned, it was discovered to be a human homolog of the E. coli mismatch
repair gene mutS.
1. How many hits will you get if you search genes associated with colon cancer in human genome?
answer: 17hits (link)
2. How many loci will you find if you search locus link for human in Genbank?
answer: 21 loci (link)
3. Give the locus ID and position of MLH1.
answer: locus ID : 4292 ; position : 3p21.3 (link)
4. Find the %ID of nucleotide sequence for its possible orthologs in mouse.
answer: 89.3% (link)
5. Find the total number of mutations of MLH1 reported in human gene mutation
database.
answer: 147 (link)
6. Give the DNA sequence of MLH1.
answer : link
7. Give the DNA sequence of E. coli mismatch repair gene mutS.
answer: link