范盛娟
Division of Biostatistics,
Department of Preventive Medicine
and Environmental Health,
University of Iowa, Iowa City, Iowa, US
助研究員
FAX : 02-27823047
TEL : 02-27899144
E-mail : csjfann@ibms.sinica.edu.tw

Speciality:

  1. Use of linkage analysis, association analysis and methodological approaches to study human complex diseases.
  2. Use of Monte Carlo methods to study various theoretical issues in genetic linkage analysis.
  3. General biostatistical consultations (Survival Analysis, Longitudinal Analysis, Power and Sample size calculations, etc.)

研究興趣 :

本實驗室之研究方向為發展、加強及應用統計方法於人類遺傳學的領域。生物統計的應用非常廣泛，無論是在流行病學、環境衛生，甚至在生物科技、臨床試藥研究都可見到它的蹤跡，而生物統計的重要性也是有目共睹。本實驗室的主要目標在發展應用遺傳統計方法來找尋人類常見疾病的致病因。研究主題有下列幾項：

  1. 應用聯結分析（Linkage analysis）及相關分析(association analysis)找尋年輕型高血壓、酒癮、毒品及憂鬱症的致病基因。
  2. 發展統計方法處理家族資料常見的族群不均衡所造成的偏差。
  3. 發展處理生物晶片資料的統計方法。

Selected Recent Publication :

  1. Fann CSJ and Ott J
    Parsimonious Estimation of Sex Specific Map Distances by Stepwise Maximum Likelihood regression. Genomics, 29:571-575, 1995.
  2. Pauls DL, Ott J, Paul SM, Allen CR, Fann CSJ, Carulli JP, Falls KM, Bouthillier CA, Gravius TC, Keith TP, Egeland JA, Ginns EI
    Linkage Analysis of Chromosome 18 Markers Do Not Identify a Major Susceptibility Locus for Bipolar Affective Disorder in the Old Order Amish. Am. J. Hum. Genet. 57:636-643, 1995.
  3. Ginns EI, Ott J, Egeland JA, Allen CR, Fann CSJ, Pauls DL, Weissenbach J, Carulli JP, Falls KM, Keith TP, Paul SM
    Genome-Wide Search for Chromosomal Loci Linked to Bipolar Affective Disorder in the Old Order Amish. Nature Genetics, 12(4), 431-435, 1996.
  4. Fann CSJ, Brancolini V
    "A new version of Cyrillic: overview" (software review), European Journal of Human Genetics, 4(3), 188, 1996.
  5. Pauls DL, Ott J, Paul SM, Allen CR, Fann CSJ, Carulli JP, Falls KM, Bouthillier CA, Gravius TC, Keith TP, Egeland JA, Ginns EI
    "Chromosome 18 Markers: Linked or Not Linked to Bipolar Affective Disorders in the Old Order Amish? A Reply to Gershon et al", Am. J. of Hum Genet, 58(6), 1384-1385, 1996.
  6. Fann CSJ, Haghighi F, Li W
    Linkage Analysis of Bipolar Disorder Using Affected Sib-Pair Methods. Proceeding of Genetic Analysis Workshop 10, Volume I, 52-56, 1996.
  7. Haghighi F, Li W, Fann CSJ
    Affected-sib-pair analysis of Bipolar Disorder Using Data on Chromosome 18. Genet. Epidemiology, 14(6), 641-646, 1997.
  8. Li W, Fann CSJ, Ott J
    Low-Order Polynomial Trends of Female-to-Male Map Distance Ratios along Human Chromosomes. Human Heredity, 48(5), 266-270, 1998.
  9. Ginns EI, St Jean P, Philibert RA, Galdzicka M, Damschroder-Williams P, Thiel B, Long RT, Ingraham LJ, Dalwaldi H, Murray MA, Ehlert M, Paul S, Remortel BG, Patel AP, Anderson MCH, Shaio C, Lau E, Dymarskaia I, Martin BM, Stubblefield B, Falls KM, Carulli JP, Keith TP, Fann CSJ, Lacy LG, Allen CR, Hostetter AM, Elston RC, Shork NJ, Egeland JA, Paul SM
    A Genome-Wide Search for Chromosomal Loci Linked to Mental Health Wellness in Relatives at High Risk for Bipolar Affective Disorder among the Old Order Amish. Proc Natl Acad Sci U S A. 22; 95(26): 15531-6, 1998.
  10. Fann CSJ, ShugartY, Lachman H, Collins A, Chang CJ
    The Impact of Redefining Affection Status for Alcoholism on Affected Sib Pair Analysis. Genet. Epidemiology 17(suppl 1): S151-S156, 1999.
  11. Wassertheil-Smoller S, Fann CSJ, Allman RM, Black HR, Camel GH, Davis B, Masaki K, Pressel S, Prineas R, Stamler J, Vogt TM
    Relation of Low Body Mass to Death and Stroke in the Systolic Hypertension in the Elderly Program. Archive of Internal Medicine, vol 160:494-500,2000.

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