PROSITE: PDOC00005 (documentation)

{PDOC00005}
 {PS00005; PKC_PHOSPHO_SITE}
 {BEGIN}
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* Protein kinase C phosphorylation site *
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In vivo, protein kinase C  exhibits  a  preference  for the phosphorylation of
serine or  threonine residues found close to a C-terminal basic residue [1,2].
The presence  of  additional   basic residues at the  N- or C-terminal of  the
target amino acid enhances the Vmax and Km of the phosphorylation reaction.

-Consensus pattern: [ST]-x-[RK]
                    [S or T is the phosphorylation site]
-Last update: June 1988 / First entry.

[ 1] Woodget J.R., Gould K.L., Hunter T.
     Eur. J. Biochem. 161:177-184(1986).
[ 2] Kishimoto A., Nishiyama K., Nakanishi H., Uratsuji Y., Nomura H.,
     Takeyama Y., Nishizuka Y.
     J. Biol. Chem. 260:12492-12499(1985).
{END}