| a, Structures of the src SH3 domain,
b, the wt a-spectrin SH3 domain and c, the distal
loop permutant, d, CI2 and e, the Arc repressor
dimer colored by FF value on a continuous scale from red
(1) to blue (0). The transition
state stability has a polarized patteern in the distal loop region, which
is out side of the hydrophobic core. While the transition state stability
is uniformly distributed around the hydrophobic core of CI-2 and Arc repressor.
(Figure adopted from Grantcharova et al., Natu. Struct.
Biol., 1998, 5(8):714) |
3a.gif)
3d.gif)