1a.gif)
src-SH3 and alpha-spectrin have almost identical toppology,
but only 36% sequence homolohy.
1.gif)
2.gif)
src-SH3
alpha-spectrin
value from red (1) to blue
(0). Residues colored in white were either not mutated or the
mutation did not affect 
G
significantly. Residues colored in yellow increased or decreased both kf
and ku, suggesting that these mutations affect the transition state more
than the native state. (Figure adopted from
Riddle et al., Nat. Struct. Biol., 1999, 6(11):1016) values
at pH 3.5 mapped on the structure (red,
0.8-1; orange, 0.6 - 0.8;
yellow, 0.4 - 0.6; cyan, 0.2 - 0.4;
blue, 0 - 0.2; green,
>1.2 or <-0.2). (Figure adopted from
Martinez and Serrano, Nat. Struct. Biol., 1999, 6(11):1010)