last update 2000/4/30

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publications

[Research Papers]   [Book chapters]   [Conference Papers]

Research Papers

    1. Y.C. Lou, M.T. Pai, S.R. Tzeng, S.H. Chou and J.W. Cheng, "13C Chemical Shifts and Structure Relationship in DNA Duplexes with Sheared Purine-Purine Base-pairing" (2000) in preparation.

    2. S.R. Tzeng, M.T. Pai, F.T. Lung, C.W. Wu, S.Y. Wei, J.M. Wu, and J.W. Cheng, "Stability and Peptide Binding Specificity of BTK SH2 Domain: Molecular Basis for X-Linked Agammaglobulinemia" (2000) Submitted.

       
    3. S.T. Hsu, M.T. Chou, and J.W. Cheng, "The Solution Structure of [d(CGC)r(aaa)d(TTTGCG)]2: Hybrid Junctions Flanked by DNA Duplexes" (2000) Nucleic Acids Research 28, 1322-1331.

    4. Y.C. Lou, I.J. Lin, M.T. Pai, and J.W. Cheng, "Solution Structure of an N-Capping Peptide from the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (2000) Archives of Biochemistry and Biophysics in press.

    5. S.R. Tzeng, Y.C. Lou, M.T. Pai, and J.W. Cheng, "Solution Structure of the BTK SH3 Domain Complexed with a Proline-Rich Peptide from p120cbl" (2000) Journal of Biomolecular NMR 16, 303-312.

    6. S.T. Hsu, M.T. Chou, S.H. Chou, W.C. Huang, and J.W. Cheng, "Hydration of [d(CGC)r(aaa)d(TTTGCG)]2" (2000) Journal of Molecular Biology 295, 1129-1137.
       
       
    7. Y.C. Lou, F.T. Lung, M.T. Pai, S.R. Tzeng, P.P. Roller and J.W. Cheng, "Solution Structure and Dynamics of a Nonphosphorelated Cyclic Peptide Inhibitor for the Grb2 SH2 Domain" (1999) Archives of Biochemistry and Biophysics 372, 309-314.
       
       
    8. S.H. Chou, Y.Y. Tseng, Y.R. Chen, and J.W. Cheng, "Structural Studies of Symmetric DNA Undecamers Containing Non-Symmetrical Sheared (PuGAPu):(PyGAPy) Motifs" (1999) Journal of Biomolecular NMR 14, 157-167.
       
       
    9. I.J. Lin, Y.C. Lou, M.T. Pai, H.N. Wu and J.W. Cheng, "Solution Structure and RNA Binding Activity of the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (1999) PROTEINS: Structure, Function, and Genetics 37, 121-129.

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    10. J.W. Cheng, I.J. Lin, Y.C. Lou, M.T. Pai, and H.N. Wu, "Local Helix Content and Nucleic Acid Binding Activity of the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (1998) Journal of Biomolecular NMR 12, 183-188.

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    11. C.C. Cheng, Y.H. Jian, C.J. Lo, and J.W. Cheng, "Design and Characterization of a Short HMG-I/DAT1 Chimeric Peptide that Binds Specifically to the Minor Groove of DNA" (1998) Journal of the Chinese Chemical Society 45, 619-624.
       
       
    12. C.S. Lee, T.K.S. Kumar, J.W. Cheng, and C. Yu, "Main-Chain Dynamics of Cardiotoxin II from Taiwan Cobra (Naja naja atra) as Studied by Carbon-13 NMR at Natural Abundance - Delineation of the role of functionally important residues" (1998) Biochemistry 37, 155-164.
       
       
    13. H.V. Patel, S.R. Tzeng, C.Y. Liao, S.H. Chen, and J.W. Cheng, "SH3 Domain of Bruton's Tyrosine Kinase can Bind to Proline-Rich Peptides of TH Domain of the Kinase and p120cbl" (1997) PROTEINS: Structure, Function, and Genetics 29, 545-552.
       
       
    14. Y.J. Chen, S.C. Lin, S.R. Tzeng, H.V. Patel, P.C. Lyu, and J.W. Cheng, "Stability and Folding of the SH3 Domain of Bruton's Tyrosine Kinase" (1996) PROTEINS: Structure, Function, and Genetics 26, 465-471.
       
       
    15. S.H. Chou, L. Zhu, Z. Gao, J.W. Cheng, and B.R. Reid, "Hairpin Loops Consisting of Single Adenine Residues Closed by Sheared AA and GG Pairs Formed by the DNA Triplets AAA and GAG: Solution Structure of the d(GTACAAAGTAC) Hairpin" (1996) Journal of Molecular Biology 264, 981-1001.
       
       
    16. J.W. Cheng, C.C. Cheng, P.C. Lyu, S.T. Chen, and T.H. Lin, "Solution Conformation of a Peptide Corresponding to Residues 151-172 of HIV-1 Integrase using NMR and CD Spectroscopy" (1996) International Journal of Peptide & Protein Research 47, 117-122.

    17. J.W. Cheng, C. Chen, T.H. Huang, S.H. Chou, and S.H. Chen, "Conformation of the Propeptide Domain of Factor IX" (1995) Biochimica et Biophysica Acta 1245, 227-231.

    18. S.H. Chou, J.W. Cheng, O. Fedoroff, and B.R. Reid "DNA Sequence GCGAATGAGC Containing the Human Centromere Core Sequence GAAT Forms a Self-complementary Duplex with Sheared GA Pairs in Solution" (1994) Journal of Molecular Biology 241, 467-479.

    19. C.A. Lepre, D.A. Pearlman, J.W. Cheng, M.T. DeCenzo, D.J. Livingston, and J.M. Moore "Solution Structure of FK506 Bound to the R42K, H87V Double Mutant of FKBP-12" (1994) Biochemistry 33, 13571-13580.

    20. J.W. Cheng, C.A. Lepre, and J.M. Moore "15N NMR Relaxation Studies of the FK506 Binding Protein: Dynamic Effects of Ligand Binding and Implications of Calcineurin Recognition" (1994) Biochemistry 33, 4093-4100.

    21. J.W. Cheng, C.A. Lepre, S. Chambers, J. R. Fulghum, J. A. Thomson, J.M. Moore, "15N NMR Relaxation Studies of the FK506 Binding Protein: Backbone Dynamics of the Uncomplexed Receptor" (1993) Biochemistry 32, 9000-9010.

    22. C.A. Lepre, J.W. Cheng, J.M. Moore "Dynamics of a receptor-bound ligand by heteronuclear NMR: FK506 bound to FKBP-12" (1993) J. Am. Chem. Soc. 115, 4929-4930.

    23. S.H. Chou, J.W. Cheng, O. Fedoroff, V. Chuprina, and B.R. Reid, "Adjacent G:A Mismatch Base Pairs Contain BII Phosphodiesters in Solution." (1992) J. Am. Chem. Soc. 114, 3114-3115.

    24. J.W. Cheng, S.H. Chou, and B.R. Reid, "Base Pairing Geometry in GA Mismatches Depends Entirely on the Neighboring Sequence" (1992) Journal of Molecular Biology 228, 1037-1041.

    25. S.H. Chou, J.W. Cheng, and B.R. Reid, "The solution structure of [d(ATGTGCGAATA)]2: Adjacent GA Mismatches Stabilized By Cross-Strand Base-Stacking and BII phosphate Groups." (1992) Journal of Molecular Biology 228, 138-155.

    26. J.W. Cheng, S.H. Chou, M. Salazar, and B.R. Reid, "The solution structure of [d(GCGTATACGC)]2," (1992) Journal of Molecular Biology 228, 118-137.

    27. J.W. Cheng, and F.T. Luo, "Palladium-Catalyzed intramolecular arylpalladation via ultrasonics," Bull. Inst. Chem, Academia Sinica 36, 9-15 (1989).

    28. B. O'connor, Yantao Zhang, N. Eiichi, F.T. Luo, and J.W. Cheng, "Metal promoted cyclizations. 20. Palladium catalyzed cyclization of alkenyl and aryl halides containing a,b-unsaturated carbonyl groups via intramolecular carbopalladation," Tetrahedron Letters 29, 3903-3906 (1988).

    29. J.W. Cheng, and F.T. Luo, "Coupling of aryl grignard reagents by electron transfer to 2,3-dichloropropene," Tetrahedron Letters 29, 1293-1294 (1988).

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Book Chapters

    1.  J.W. Cheng, "Rational Drug Design" (1998) Advanced Biotechnology, edited by Jung-Yaw Lin, The Ministry of Education, Taiwan, ROC.

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    2. J.W. Cheng, H.V. Patel, S.R. Tzeng, and C.Y. Liao, "Stability and Binding of SH3 Domain of Bruton's Tyrosine Kinase" (1997) Peptides: Chemistry, Structure and Biology, edited by James P. Tam, Mayflower Scientific Ltd, UK.

      3.  

    3. S.H. Chou, J.W. Cheng, O. Fedoroff, and B.R. Reid "DNA, d(GCGAATGAGC)2, NMR" (1995) Macromolecular Structures 1995, 596-597, edited by Wayne Hendrickson and Kurt Wuthrich, Current Biology Ltd.

      4.  

    Conference Papers

    1. J.W. Cheng, "Stability and Binding of an intramolecular regulated SH3 Domain from Bruton's Tyrosine Kinase" (1998) Oral Presentation, The Fourth Symposium on Recent Advances in Biophysics, Taiwan, ROC.

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    2. S.R. Tzeng, M.T. Pai, Y.C. Lou, I.J. Lin, S.Y. Wei, M.T. Chou, S.T. Hsu, and J.W. Cheng, "Stability and Binding of an intramolecular regulated SH3 Domain from Bruton's Tyrosine Kinase" (1998) P#23, The Fourth Symposium on Recent Advances in Biophysics, Taiwan, ROC.

      3.  
       
    3. I.J. Lin, Y.C. Lou, M.T. Pai, S.R. Tzeng, S.Y. Wei, M.T. Chou, S.T. Hsu, H.N. Wu, and Jya-Wei Cheng, "Local Helix Content and Nucleic Acid Binding Activity of the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (1998) P#12, The Fourth Symposium on Recent Advances in Biophysics, Taiwan, ROC.

      4.  
       
    4. J.W. Cheng, M.T. Pai, S.Y. Wei, and Y.C. Lou, "15N Relaxation Studies of a Proline-Rich Peptide Bound to the SH3 Domain of Bruton's Tyrosine Kinase" (1998) P#188, 39th ENC, Asilomar, CA, USA.

      5.  
       
    5. Y.C. Lou, I.J. Lin, M.T. Pai, H.N. Wu, and J.W. Cheng, "Local Helix Content and RNA Binding Activity of the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (1998) P#189, 39th ENC, Asilomar, CA, USA.

      6.  
       
    6. S.R. Tzeng, M.T. Chou, M.T. Pai, and J.W. Cheng, "Stability and Binding of SH3 Domain of Bruton's Tyrosine Kinase" (1998) P#229, 39th ENC, Asilomar, CA, USA.

      7.  
       
    7. Jya-Wei Cheng, I-Jin Lin, Yuan-Chou Lou, Ming-Tao Pai, and Huey-Nan Wu, "Local Helix Content and Nucleic Acid Binding Activity of the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (1997) Oral Presentation, First Taiwan-Japan Nuclear Magnetic Resonance Symposium.

      8.  
       
    8. J.W. Cheng, H.V. Patel, S.R. Tzeng, and C.Y. Liao, "Stability and Binding of SH3 Domain of Bruton's Tyrosine Kinase" (1997) P#25, First Taiwan-Japan Nuclear Magnetic Resonance Symposium.

      9.  
       
    9. J.W. Cheng, H.V. Patel, S.R. Tzeng, and C.Y. Liao, "Stability and Binding of SH3 Domain of Bruton's Tyrosine Kinase" (1997) P#299, Fifteenth American Peptide Symposium.

      10.  
       
    10. H.V. Patel, S.R. Tzeng, C.Y. Liao, and J.W. Cheng, "Binding of SH3 Domain of Bruton's Tyrosine Kinase to Proline-Rich Peptides of TH Domain of The Kinase and of P120CBL" (1997) P#296, Fifteenth American Peptide Symposium.

      11.  
       
    11. J.W. Cheng, Y.J. Chen, S.C. Lin, S.R. Tzeng, and P.C. Lyu "Structure and Stability of the SH3 Domain from Bruton's Tyrosine Kinase (BTK)" (1996) Oral Presentation, The second symposium on recent advances in biophysics, ROC.

      12.  
       
    12. J.W. Cheng, Y.J. Chen, S.C. Lin, S.R. Tzeng, and P.C. Lyu "Solution Structure and Peptide Binding Specificity of the SH3 Domain from Bruton's Tyrosine Kinase (BTK)" (1996) P#243, 37th ENC, Asilomar, CA, USA.

      13.  
       
    13. J.W. Cheng, C.C. Cheng, P.C. Lyu, S.T. Chen, and T.H. Lin "Solution Structure of the Leucine Zipper Motif of HIV Type 1 Integrase" (1995) P#1, International Chemical Conference Taipei - V, Taiwan, ROC.

      14.  
       
    14. J.W. Cheng, C.C. Cheng, P.C. Lyu, S.T. Chen, and T.H. Lin "Solution Structure of the Leucine Zipper Motif of HIV Type 1 Integrase" (1995) D2-307 Frontiers of NMR in Molecular Biology-IV, Keystone symposia, USA. 

      15.  

       

    15. J.W. Cheng, C.C. Cheng, P.C. Lyu, S.T. Chen, and T.H. Lin "Solution Structure of the Leucine Zipper Motif of HIV Type 1 Integrase" (1995) D2-307 Frontiers of NMR in Molecular Biology-IV, Keystone symposia, USA.

      16.  

    16. P.C. Lyu, J.W. Cheng, and C.S. Chen "Solution Conformation of the NMDA Antagonist Conantokint" (1995) D2-227 Frontiers of NMR in Molecular Biology-IV, Keystone symposia, USA.

      17.  

    17. J.W. Cheng, C.C. Cheng, P.C. Lyu, S.T. Chen, and T.H. Lin "Solution Structure of The Leucine Zipper Motif of HIV Type 1 Integrase" (1995) Frontier NMR Research Symposium P16, Academia Sinica, Taipei, Taiwan.

      18.  

    18. P.C. Lyu, J.W. Cheng, and C.S. Chen "Solution Conformation of The NMDA Antagonist Conantokint" (1995) Frontier NMR Research Symposium P17, Academia Sinica, Taipei, Taiwan.

      19.  

    19. J.W. Cheng, C.A. Lepre, S. Chambers, J. R. Fulghum, J. A. Thomson, J.M. Moore, "15N NMR Relaxation Studies of The FK506 Binding Protein: Backbone Dynamics of The Uncomplexed Receptor" (1993) Frontiers of NMR in Molecular Biology-III, Keystone symposia, USA.

      20.  

    20. J.W. Cheng, S.H. Chou, and B.R. Reid "Sequence Effects on Local DNA Topology: BI/BII Phosphate Change of Adjacent GA Mismatches" Oral Presentation (1992) XV International Conference on Magnetic Resonance in Biological Systems, Jerusalem, Israel.

      21.  

    21. S.H. Chou, J.W. Cheng, and B.R. Reid "The Solution Structure of [d(ATGTGCGAATA)]2: Adjacent GA Mismatches Stabilized by Cross-strand Base-Stacking and BII Phosphate Groups" (1992) ISMAR 92, Vancouver, BC, Canada.

      22.  

    22. J.W. Cheng, S.H. Chou, and B.R. Reid "Nuclear Magnetic Resonance Studies of an RNA Duplex with Consecutive UU Mismatches" (1992) p62, The 33rd ENC, Asilomar, CA, USA.

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