Journal Articles:

Representative publication list (2007-2013)

  • Wan, C.-F., Chen, W.-H., Chen, Cheng-Ta, Chang, M. D.-T., Lo, L.-C., Li, Y.-K. (2007)  Mutagenesis and mechanistic study of a family 54 a-L-arabinofuranosidase from Trichoderma koningii.  Biochem. J. 401, 551-558.
  • Chang, H.-T., Kao, Y.-L., Wu, C.-M., Fan, T.-c., Huang, K.-L., Lai, Y.-K., Tsai, J.-J., Chang, M. D.-T.* (2007) Signal peptide of eosinophil cationic protein up-regulates TGF-α expression in human cells.  J. Cell. Biochem. 100, 1266-1275.
  • Liu, Y.-N., Lai, Y.-T., Chou, W.-I., Chang, M. D.-T.*, Lyu, P.-C.* (2007) Solution structure of family 21 carbohydrate-binding module from Rhizopus oryzae glucoamylase.  Biochem. J. 403, 21-30.
  • Huang, Y.-C., Lin, Y.-M., Chang, T.-W., Wu, S.-J., Lee, Y.-S., Yu, H.-M., Chang, M. D.-T., Chen, C, Wu, S.-H., Liao, Y.-D. (2007)  The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.  J. Biol. Chem. 282, 4526-4633.
  • Lin, S.-C., Liu, W.-T., Liu, S.-H., Hsiung, B.-K., Chou, W.-I., Lin, I. P., Sheu, C.-C., Chang, M. D.-T.* (2007) Role of the linker region in the expression of Rhizopus oryzae glucoamylase.  BMC Biochemistry 8:9.
  • Wang, H.-Y., Chang, H.-T., Pai, T.-W., Wu, C.-I., Lee, Y.-H., Tai, S.-L., Tang, C.-Y., Chou, W.-Y., Chang, M. D.-T. * (2007) Transcriptional regulation of eosinophil derived neurotoxin by MAZ and Sp1 is governed by a characteristic DNA sequence motif. BMC Mol. Biol. 8:89.
  • Fan, T.-c., Chang, H.-T., Chen, I.-W., Wang, H.-Y., Chang, M. D.-T.* (2007) A heparan sulfate facilitated pathway for the internalization of eosinophil cationic protein through lipid raft-dependent macropinocytosis.  Traffic 8: 1778-1795.
  • Tsai, C.-H., Chen, C.-P., Chang, M.D.-T., Chang, S.-J., Chien, S.-C. (2007)  Hematometrocolpos secondary to didelphic uterus and unilateral imperforated double vagina as an unusal cause of acute abdomen.  Taiwan J. Obstet. Gynecol. 47, 448-452.
  • Shu, C.-W., Sun, F.-C., Cho, J.-H., Lin, C.-C., Chen, P.-Y., Chang, M. D.-T., Fu, H.-W., Lai, Y.-K. (2008) Cooperation of GRP78 and Raf-1 confers resistance to endoplasmic reticulum stress-induced apoptosis.  J. Cell. Physiol., 215, 627-35.
  • Chao, C.-C., Sun, F.-C., Wang, C.-H., Lo, C.-W., Chang, Y.-S., Chang, K.-C., Chang, M. D.-T., Lai, Y.-K. (2008) Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells. J. Cell. Biochem., 104, 1286-96.
  • Yen, C.-N., Lin, Y.-R., Chang, M. D.-T., Tien, C.-W., Wu, Y.-C., Liao, C.-J., Hu, Y.-C. (2008) Use of porous alginate sponges for substantial chondrocyte expansion and matrix production: Effects of seeding density. Biotechnol. Prog., 24, 452-7.
  • Huang, R.-Y., Chang, H.-T., Lan, C.-Y., Pai, T.-W., Wu, C.-N., Lin, J.-M., Chang, M. D.-T.* (2008) Development and evaluation of a sensitive enzyme-linked oligosorbent assay for detection of polymerase chain reaction amplified hepatitis C virus of genotypes 1 to 6. J. Virol. Method., 151, 211-216.
  • Fan, T.-c., Fang, S.-l., Hwang, C.-S., Hsu, C.-Y., Lu, X.-A., Hung, S.-C., Lin, S.-C., Chang, M. D.-T.* (2008) Characterization of molecular interactions between eosinophil cationic protein and heparin. J. Biol. Chem., 283, 25468-25474.
  • Tung, R.-Y., Chang, M. D.-T., Chou, W.-I., Liu, Y.-Y., Yeh, Y.-H., Chang, F.-Y., Lin, S.-C., Qiu, Z.-L., Sun, Y.-J. (2008) Crystal structures of starch binding domain of Rhizopus oryzae glucoamylase reveal a polysaccharide binding path. Biochem. J. 416, 27-36.
  • Liu, W.-T., Lin, S.-C., Chou, W.-I., Liu, T.-H., Pan, R.-L., Tzou, D.-L., Hua, T.-E., Chang, M. D.-T.* (2008)  Identification and characterization of a novel fibril forming peptide in fungal starch binding domain. Biochem. Biophys. Res. Commun. 377, 966-970.
  • Chang, S.-J., Huang, T.-S., Wang, K.-L., Wang, T.-Y., Yang, Y.-C., Chang, M. D.-T., Wu, Y.-H., Wang, H.-W. (2008)  Genetic network analysis of human CD34+ hematopoietic stem/precursor cells.  Taiwan J. Obstet. Gynecol. 47, 422-430.
  • Wang, H.-Y., Ho, P.-C., Lan, C.-Y., Chang, M. D.-T.* (2009) Transcription regulation of human eosinophil RNases by the liver-enriched hepatocyte nuclear factor 4.  J. Cell. Biochem. 106, 317-326.
  • Lin, S.-C., Lin, I.-P., Chou, W.-I., Hsieh, C.-A., Liu, S.-H., Huang, R.-Y., Sheu, C.-C., Chang, M. D.-T.* (2009) CBM21 starch-binding domain: a new purification tag for recombinant protein engineering.  Protein Expr. Purif. 65, 261-266.
  • Lo, C.-W., Chang, Y.-S., Chao, C.-C., Chang, M. D.-T., Chang, K.-C., Lai, Y.-K. (2009) Control mechanisms of differential translation of Hsp90 isoforms in 9L rat gliosarcoma cells. J. Cell. Biochem. 107, 418-427.
  • Huang, Y.-F., Chang, M. D.-T., Shieh, S.-Y. (2009) TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.  Mol. Cell. Biol. 29, 2935-2944.
  • Chen, K.-Y., Chen, C.-Y., Chang, M. D.-T., Matsuura, Y., Hu, Y.-C. (2009)  Concanavalin A affinity chromatography for efficient baculovirus purification.  Biotechnol. Prog. J. 25, 1669-1677.
  • Chang, S.-J., Hu, T.-F., Wang, T.-Y., Chang, M. D.-T., Wang, H.-W. (2009)  Distinct gene expression and increased epithelial precursor traits in advanced endometrial endometroid carcinoma. BMC Genomics 10, 613.
  • Wang, T.-Y., Chang, S.-J., Chang, M. D.-T., Wang, H.-W. (2009)  Unique biological properties and application potentials of CD34+ CD38- stem cells from various sources.  Taiwan J. Obstet. Gynecol. 48, 356-369.
  • Chang, K.-C., Lo, C.-W., Fan, T.-c., Chang, M. D.-T., Chang, C.-H., Chung, C.-T., Fang, S.-l., Chao, C.-C., Tsai, J.-J., Lai, Y.-K. (2010)  TNF-α mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells.  BMC Cell Biology 11, 6.
  • Lin, Y.-M., Wu, S.-J., Chang, T.-W., Wang, C.-F., Suen C.-S., Hwang, M.-J., Chang, M. D.-T.,  Chen, Y.-T.., Liao, Y.-D. (2010)  Outer membrane protein I of Pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein. J. Biol. Chem. 285, 8985-8994.
  • Chou, W.-Y., Chou, W.-I., Pai, T.-W., Lin, S.-C., Jiang, T.-Y., Tang, C.-Y., Chang, M. D.-T.* (2010) Ligand-binding residue prediction for carbohydrate binding modules based on feature-incorporated alignment. Bioinformatics 26, 1022-1028.
  • Chang, H.-T., Tseng, L.-J., Hung, T.-J., Kao, B.-T., Lin, W.-Y., Fan, T.-c., Chang, M. D.-T., Pai, T.-W. (2010)  Inhibition of the interactions between eosinophil cationic protein and airway epithelial cells by traditional Chinese herbs. BMC Syst. Biol. 4, Suppl. 2:S8.
  • Chen, J.-C., Uang, B.-J., Lyu, P.-C., Chang, J.-Y., Liu, K.-J., Kuo, C.-C., Hsieh, H.-P., Wang, H.-C., Cheng, C.-S., Chang, M. D.-T.*, Chang, W.-S. W.*, Lin, C.-C.* (2010)  Design and synthesis of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. J. Med. Chem. 53, 4545-4549.
  • Chuang, C.-S. Pai, T.-W., Hu, C.-H., Tzou, W.-S., Chang, M. D.-T., Chang, H.-T., Chen, C.-C. (2011) Functional pathway mapping analysis for hypoxia-inducible factors.  BMC Syst. Biol. 5, Suppl. 1:S3.
  • Chou, W.-Y., Pai, T.-W., Jiang, T.-Y., Chou, W.-I., Tang, C.-Y., Chang, M. D.-T.* (2011) Hydrophilic aromatic residue correlation and structure modeling for carbohydrate binding modules. PloS ONE 6:e24814. Epub 2011 Sep 22.
  • Weng, S.-L., Chang, S.-J., Cheng, Y.-C., Wang, H.-Y., Wang, T.-Y., Chang, M. D.-T., Wang, H.-W. (2011)  Comparative transcriptome analysis reveals a fetus origin of cord blood mesenchymal stem cells and novel fetal surface antigens for non-invasive prenatal diagnosis.  Taiwan J. Obstet. Gynecol. 50, 447-457.
  • Chang, S.-J., Weng, S.-L., Hsieh, J.-Y., Wang, T.-Y., Chang, M. D.-T., Wang, H.-W. (2011)  MicroRNA-34a modulates genes involved in cellular motility and oxidative phosphorylation in neuronal precursors derived from human umbilical cord mesenchymal stem cells.  BMC Genomics 4, 65.
  • Hung, S.-C.*, Lu, X.-A., Lee, J.-C., Chang, M. D.-T.*, Fang, S.-l., Fan, T.-c., Zulueta, M. M. L., Zhong, Y.-Q. (2012)  Synthesis of heparin oligosaccharides and their interaction with eosinophil-derived neurotoxin.  Org. Biomol. Chem. 10, 760-772.
  • Jiang, T.-Y., Ci, Y.-P., Chou, W.-I., Lee, Y.-C., Sun, Y.-J., Chou, W.-Y., Li, K.-M., Chang, M. D.-T.* (2012) Disruption of amylose helical structure by Rhizopus oryzae starch binding domain with unique dual ligand binding clamps. PloS ONE 7:e41131.
  • Liu, Y.-S., Tsai, P.-W., Wang, Y., Fan, T.-c., Hsieh, C.-H., Chang, M. D.-T., Pai, T.-W., Huang, C.-F., Lan, C.-Y., Chang, H.-T. (2012) Chemoattraction of macrophages by secretory molecules derived from cell expression the signal peptide of eosinophil cationic protein. BMC Systems Biol. 6:105.
  • Lin, S.-T., Chou, H.-C., Chang, S.-J., Chen, Y.-W., Lyu, P.-C., Wang, W.-C., Chang, M. D.-T., Chan, H.-L. (2012) Proteomic analysis of proteins responsible for the development of doxorubicin resistance in human uterine cancer cells. J. Proteomics 75, 5822-5847.
  • Chen, H.-C., Chang, H.-T., Huang, D.-H., Chang, M. D.-T., Liu, R.-S., Liu, C.-F., Hsieh, C.-H. (2013) Molecular imaging of heparan sulfate expression with radiolabelled rECP predicts lung allergic inflammation in a mouse model for asthma. J. Nucl. Med. (accepted on Nov. 26, 2012)
  • Lien, P.-C., Kuo, P.-H., Chen, C.-J., Chang, H.-H., Fang, S.-l., Wu, W.-S., Pai, T.-W., Lai, Y.-K., Chang, M. D.-T.* (2013) In silico prediction and in vitro characterization of multifunctional human RNase3. BioMed. Res. Int’l. vol. 13, Article ID 170398 (accepted on Dec. 3, 2012).
  • Lin, S.-L., Lo, Y.-W., Chang, S.-j., Wang, W.-C., Chang, M. D.-T., Lyu, P.-C., Chen, Y.-W., Chan, H.-L. (2013) Redox-proteomic analysis of doxorubicin resistance-induced altered thiol activity in uterine carcinoma. J. Pharm. & Biomed. Anal. (accepted on Jan. 19, 2013).
  • Fang, S.-l., Fan, T.-c., Fu, H.-W., Chen, C.-J., Hwang, C.-S., Hung, T.-J., Lin, L.-Y., Chang, M. D.-T.* (2013) A novel cell-penetrating peptide from human eosinophil cationic protein. PLoS ONE (accepted on Jan. 21, 2013).
  • Chen, C.-M., Shih, T.-H., Pai, T.-W., Liu, Z.-L., Chang, M. D.-T., Hu, C.-H. (2013) Gene expression rate comparison for multiple high-throughput datasets. IET Systems Biolology (accepted on Jan. 22, 2013).
  • Lien, S.-C., Chang, S.-F., Chang, M. D.-T., Chang, J.-Y., Chiu, J.-J. (2013) Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells. Cell Signal. (Accepted on Feb. 1, 2013).
  • Hwang, C.-S., Liu, G.-T., Liao, I.-L., Chang, M. D.-T.*, Chang, H.-T.* (2013) Elevated serum autoantibodies against high motility group box-1 and heat shock proteins as surrogate biomarkers for amyotrophic lateral sclerosis. (in revision).
  • Fu, L-S., Fang, S.-l., Tsai, J.-J., Lin, H.-k., Chen, Y.-j., Lien, P.-C., Chang, M. D.-T.* (2013) Heparan sulfate-binding peptide protects BALB/c mice from mite-induced airway allergic inflammation. (submitted).
  • Fu, L.-s., Tsai, J.-J., Lin, H.-k., Chen, Y.-j, Lin, W.-y., Tsai, M.-c., Chang, M. D.-T. (2013) Heparin protects BALB/c mice from mite induced airway allergic inflammation. (submitted).
  • Lien, S.-C., Wei, S.-Y., Chang, S.-F., Chang, M. D.-T., Chang, J.-Y., Chiu, J.-J. (2013) Laminar shear stress induces autophagy and apoptosis of cancer cells: Roles of bone morphogenetic protein receptor, Smad1/5, p38. (submitted).
  • Huang, M., Chang, M. D.-T., Ng, S.-K., Yu, C.-H., Yang, X.-Y., Lai, Y.-K. (2013) Identification of anti-inflammatory fractions of Geranium wilfordii Maxim using tumor necrosis factor-alpha as a drug target. HerboChip®-An array-based high throughput screening platform. (submitted).
  • Tsai, J.-Y., Lee, M.-J., Chang, M. D.-T.*, Huang, H.* (2013) The effect of catalase on migration and invasion of lung cancer cells by regulating the activities of cathepsin S, L, and K. (submitted).

Book Section

  • Chang, M. D.-T., Chang, H.-T., Tzou, W.-S., Liu, C.-H., Zhung, W.-J., Wang, H.-W., Chang, C.-T., Huang, R.-Y., Pai, T.-W. (2007)  A database for prediction of unique peptide motifs as linear epitopes.  Bioinformatics Research and Applications, LNBI 4463 (LNCS Subseries), Ed Mandoiu, I. and Zelikovsky, A., ISSN 0302-9743, Springer, Germany, 430-440.
  • Chen, C.-M., Hsiao, M.-C., Pai, T.-W., Cheng, R., Tzou, W.-S., Chang, M. D.-T. (2008)  Identify SSR regulators for functional gene sets through cross-species comparison.  Optimization and Systems Biology, Lecture Notes in Operations Research (LNOR), vol. 9, Ed. Du, D.-Z. and Zhang, X.-S., ISSN978-5062-9298-4.
  • Chou, W.-Y., Chou, W.-Y., Lin, S.-C., Jiang, T.-Y., Tang, C.-Y., Chang, M. D.-T.* (2008) Functional residue prediction by multiple sequence alignment for carbohydrate binding modules.  JCIS-2008 Proceedings, Advances in Intelligent Systems Research.  ISBN: 978-90-78677-18-5, ISSN: 1951-6851.
  • Chou, W.-Y., Pai, T.-W., Lai, J. Z.-C., Tzou, W.-S, Chang, , M. D.-T., Chang, H.T., Chou, W.-Y., Fan, T.-c.,(2008)  Multiple Indexing Sequence Alignment for Group Feature Identification, Series on Advances in Bioinformatics and Computational Biology, Vol. 8, Regulatory Genomics, Eds: Wai, L.-H., Sung, W.-K., and Eslon, E., ISSN1751-6404, Imperial College Press, London, 85-98.
  • Tseng, L.-J., Kao, B.-T., Lin, W.-Y., Chang, M. D.-T., Pai, T.-W., Hunag, Y.-C. and Chang, H.-T. (2009)  The Potential Chinese Herbs for Inhibiting Cytotoxicity of Eosinophil Cationic Protein, The Third International Symposium on Optimization and Systems Biology (OSB 2009), Zhangjiajie, Hunan, China, Sep. 20-22. Lecture Notes in Operations Research (LNOR), Vol. 11, Eds: Chen, L., Zhang, X.-S., Wu, L.-Y., Wang, Y., ISSN 978-7-5100-0549-7, World Publishing Corporation, Beijing, 311-318.
  • Chou, W.-Y., Chou, W.-I., Lin, S.-C., Huang, R.-Y., Jiang, T.-Y., Chang, H.-T., Chen, C.-J., Wu, C.-M., Tang, C.-Y., Chang, M. D.-T.* (2009)  Biological Feature Incorporated Alignment for Cross Species Analysis on Carbohydrate Binding Modules.  BIBM2009 Proceedings, Washington D. C., USA. ISBN: 978-0-7695-3885-3, BMS Part Number CFP09BIB-PRT, Library of Congress Control Number 2009935372, IEEE Computer Society, 20-25.
  • Chang, H.-T., Chao, C.-H., Lin, Y.-F., Tseng, L.-J., Pai, T.-W., Shih, T.-H., Chang, M. D.-T., Tsai, P.-W. (2010)  Full paper and Oral presentation. Prediction of Regulatory Molecules for Enhancement of EGFR Overexpression Triggered by Signal Peptide of Ribonuclease 3.  Proceeding of 2010 IEEE International Conference on Complex, Intelligent and Software Intensive Systems (CISIS2010), pp. 672-676, Krakow, Poland, Feb. 15-18.
  • Chuang, C.-S., Chen, C.-C., Pai, T.-W., Chang, H.-T., Chang, M. D.-T. (2010)  Full paper and Oral presentation.  Functional conservation and gene expression for cross-species HIF pathway.  Proceeding of The Forth International Symposium on International Conference on Computational Systems Biology (ISB 2010), Suzhou. Sep. 9-11. Lecture Notes in Operations Research (LNOR), Vol. 13, Eds: Chen, L., Zhang, X.-S., Shen, B., Wu, L.-Y., Wang, Y. pp. 176-184.
  • Wang, H.-W., Wu, W.-K., Pai, T.-W., Chen, Y.-P. P., Chang, M. D.-T. (2011)  Impact of complex formation on predicting conformational epitopes.  Proceeding of the IASTED International conference on Computational Bioscience (CompBio2011), pp. 284-290, Camb0ridge, United Kindom.  July 11-13, 2011.
  • Tsai, Y.-L., Wang, H.-W., Pai, T.-W., Tzou, W.-S., Chang, M. D.-T. (2011)  Deformation invariant local descriptors for protein surface comparison.  Proceeding of the IASTED International conference on Computational Bioscience (CompBio2011), pp. 329-335, Cambridge, United Kindom.  July 11-13, 2011.
  • Liu, Y.-S., Chao, C.-H., Chang, H.-T., Wang, Y., Chang, M. D.-T., Pai, T.-W. (2011)  Analysis of gene expression profile triggered by signal peptide of eosinophil cationic protein.  The fifth IEEE International Conference on Systems Biology (ISB2011), Zhuhai, China.  Proceeding of 2011 IEEE Conference on Systems Biology, pp 137-143, IEEE Computer Society, Piscataway NG (EI).  IEEE Catalog Number CFP11ISB-ART, ISBN 978-1-4577-1666-9.
  • Lo, Y.-T., Shih, T.-H., Lin, H.-J., Pai, T.-W., Chang, M. D.-T. (2011)  Cross-Species Identification of Hydroxylation Sites for ARD and FIH Interaction.  The fifth IEEE International Conference on Systems Biology (ISB2011), Zhuhai, China.  Proceeding of 2011 IEEE Conference on Systems Biology, pp 345-350, IEEE Computer Society, Piscataway NG (EI).  IEEE Catalog Number CFP11ISB-ART, ISBN 978-1-4577-1666-9.
  • Kuo, P.-H., Chen, C.-J., Lien, P.-C., Chang, H.-H., Fang, S.-l., Chang, M. D.-T.*, Pai, T.-W.* (2012) Molecular identification of a unique heparin binding motif derived from human RNase3. The 6th International Conference on Complex, Intelligent, and Software Intensive Systems (CISIS 2012), pp. 603-608, Palermo, Italy, July 4-6. Proceeding of 2012 IEEE International Conference on Complex, Intelligent and Software Intensive Systems, IEEE Computer Society, Piscataway, NJ. ISBN 978-0-7695-4687-2.
  • Lien, P.-C., Chen, C.-J., Kuo, P.-H., Pai, T.-W., Chang, H.-H., Lai, Y.-K., Wu, W.-S., Chang, M. D.-T.* (2012) In silico prediction and in vitro characterization of unique function of human RNase3. The 6th International Conference on Complex, Intelligent, and Software Intensive Systems (CISIS 2012), pp. 609-614, Palermo, Italy, July 4-6. Proceeding of 2012 IEEE International Conference on Complex, Intelligent and Software Intensive Systems, IEEE Computer Society, Piscataway, NJ. ISBN 978-0-7695-4687-2.
  • Chen, C.-M., Shih, T.-H., Pai, T.-W., Liu, Z.-L., Chang, M. D.-T. (2012) RNA-seq coverage effects on biological pathways and GO tag clouds. 2012 IEEE International Conference on Systems Biology (ISB2012), pp. 241-246, Xi ’an, China, Aug. 18-20, IEEE catalog number CFP111SB-ART, ISBN 978-1-4673-4398-5.

Patents

  • Chang, M. D.-T., Fan, T.-c., Lin, S.-C.  Heparin Binding Motif and Use Thereof.  US patent 7,595,374, filing date 05/21/2008.  Issued 09/29/2009.
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein comprising starch binding domain and use thereof.  US patent 7,662,918, filing date 03/03/2005.  Issued 02/16/2010.
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein comprising starch binding domain and use thereof.  US patent 7,759,089, filing date 01/24/2007.  Divisional application.  Priority date 3/3/2005, priority no. US11/070,271, Issued 7/20/2010.
  • Chang, M. D.-T., Sheu, C.-C.  Nucleic acids for enhancing gene expression and use thereof.  US patent 7,785,872, filing date 12/08/2004.  Issued 8/31/2010.
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein comprising starch binding domain and use thereof.  US patent 7,851,215, CIP, filing date 03/03/2005.  Priority date 03/03/2005, priority no. US11/070,271.  Issued 12/14/2010.
  • Chang, M. D.-T., Sun, Y.-J., Lyu, P.-C., Lin, S.-C., Chou, W.-I.  Polysaccharide-protein binding model and nano-fibril formation of a starch binding domain, US patent 7,919,580, filing date 1/23/2009. Priority date 1/23/2008, priority no. 61/022,960.  Issued 4/5/2011.
  • 張大慈、范丹琪、林淑娟 嗜酸性球陽離子蛋白之肝素結合位及其用途。中華民國專利I359664，申請日期：97年11月21日，優先權日期：97年5月21日，優先權號：US12/125,008，核准日期：101年3月11日。
  • Chang, M. D.-T., Sheu, C.-C.  Method and system for protein purification.  South Africa 2010/03385, filing date 5/13/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Issued 2012.
  • 張大慈、許嘉欽  可提升基因表現之核酸及其用途。中華民國專利094142959，申請日期：94年12月6日。Pending。
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein and method of screening for agents that mediate polypeptide aggregation.  PCT/CN2006/000305, filing date: 03/02/2006.  Priority date 03/03/2005, priority no. US11/070,271.  Pending.
  • 張大慈、許嘉欽  重組蛋白包含澱粉鍵結區域及其應用Recombinant protein comprising starch binding domain and use thereof。中華民國專利 095106950，申請日期：95年3月2日。優先權日：94年3月3日，優先權號：美國11/070,271。Pending。
  • Chang, M. D.-T., Lyu, P.-C., Sun, Y.-J., Sheu, C.-C.  Starch binding domain and use thereof.  PCT/CN2006/002915, filing date 10/31/2006.  Pending.
  • 張大慈、呂平江、孫玉珠、許嘉欽 澱粉吸附區域及其用途 Starch binding domain and use thereof。中華民國專利096111894，申請日期：96年4月3日。優先權日：95年10月31日，優先權號：PCT/CN2006/002915。Pending。
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein comprising starch binding domain and use thereof.  Europe, 06705712.5, filing date 08/31/2007.  Priority date 03/03/2005, priority no. US11/070,271.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein comprising starch binding domain and use thereof.  Europe, DE 238000264, filing date 08/31/2007.  Priority date 03/03/2005, priority no. US11/070,271, Pending.
  • 張大慈、許嘉欽  包含澱粉結合部位的重組蛋白質及其用途/Recombinant protein comprising starch binding domain and use thereof。中國專利200680006927.x，申請日期：09/03/2007。優先權日：03/03/2005，優先權號：US11/070,271。Pending。
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein comprising starch binding domain and use thereof.  Japan 2007-557310, filing date 11/22/2007.  Priority date 03/03/2005, priority no. US11/070,271.  Pending.
  • Chang, M. D.-T., Sun, Y.-J., Lyu, P.-C.  Amyloid-like Fibril Formation of a Starch Binding Domain.  PCT/CN2008/ 61022960, filing date 1/23/2008.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Recombinant protein comprising starch binding domain and use thereof.  Hong Kong 08112881.9, filing date 11/25/2008.  Priority date 03/03/2005, priority no. US11/070,271.  Pending.
  • 張大慈、孫玉珠、呂平江、林淑娟、周維宜 多醣蛋白結合模組及澱粉吸附區上奈米原纖維之形成。中華民國專利098102749，申請日期：98年1月23日。優先權日：97年1月23日、優先權號：61/022,960。Pending。
  • Chang, M. D.-T., Lyu, P.-C., Sun, Y.-J., Sheu, C.-C.  Starch binding domain and use thereof.  Europe EPO 06 817 795.5, filing date 4/28/2009.  Priority date 10/31/2006, priority no. PCT/CN2006/002915.  Pending.
  • Chang, M. D.-T., Lyu, P.-C., Sun, Y.-J., Sheu, C.-C.  Starch binding domain and use thereof.  Japan, filing date 4/28/2009.  Priority date 10/31/2006, priority no. PCT/CN2006/002915.  Pending.
  • Chang, M. D.-T., Lyu, P.-C., Sun, Y.-J., Sheu, C.-C. Starch binding domain and use thereof.  US 12/447,848, filing date 04/29/2009.  Priority date 10/31/2006, priority no. PCT/CN2006/002915,  Pending.
  • Chang, M. D.-T., Lyu, P.-C., Sun, Y.-J., Sheu, C.-C.  Starch binding domain and use thereof.  China 200680056250.0, filing date 04/29/2009.  Priority date 10/31/2006, priority no. PCT/CN2006/002915.  Pending.
  • Chang, M. D.-T., Lee, Y.-C., Huang, R.-Y., Lin, S.-C., Chou, W.-I., Liu, S.-H.  Carbohydrate binding module and use thereof, US 12/464,788, filing date 5/12/2009.  Pending.
  • Chang, M. D.-T., Lyu, P.-C., Sun, Y.-J., Sheu, C.-C. Starch binding domain and use thereof.  India 2997/DELNP/2009, filing date 05/25/2009.  Priority date 10/31/2006, priority no. PCT/CN2006/002915.  Pending.
  • 張大慈、李遠川、黃榮淵、林淑娟、周維宜、劉錫輝 醣類結合模組及其應用。中華民國專利098124551，申請日期：98年7月22日。優先權日期：98年5月21日、優先權號：美國12/464,788。Pending。
  • Chang, M. D.-T., Fan, T.-c., Lin, S.-C.  Heparin binding motif and use thereof.  DIV US12/545,606, filing date 08/21/2009.  Priority date 05/21/2008, priority no. US12/125,008.  Pending.
  • Chang, M. D.-T., Lee, Y.-C., Huang, R.-Y., Lin, S.-C., Chou, W.-I., Liu, S.-H.  Carbohydrate binding module and use thereof.  CIP US12755242, filing date 04/06/2010.  Priority date 05/12/2009, priority no. US12/464,788.  Pending.
  • Chang, M. D.-T., Lee, Y.-C., Huang, R.-Y., Lin, S.-C., Chou, W.-I., Liu, S.-H.  Carbohydrate binding module and use thereof.  PCT/US10/34512, filing date 05/11/2010.  Priority date 05/12/2009, priority no. US12/464,788.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Use of starch binding domain as a thermostable article.  US 12/777,308, filing date 05/11/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Method and system for protein purification.  Europe EP10162698.4, filing date 5/12/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Method and system for protein purification.  Japan特願2010-111082, filing date 5/13/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Method and system for protein purification.  India 1118/DEL/2010, filing date 5/13/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Pending.
  • 張大慈、許嘉欽  蛋白質純化之方法及系統Method and system for protein purification.。中華民國專利099115444，申請日期：99年5月14日。優先權日：98年5月15日，優先權號：美國11/070,271。Pending。
  • Chang, M. D.-T., Fang, S.-l., Chou, W.-I., Lin, S.-C.   Cell penetrating peptides for intracellular delivery.  US12/780,497, filing date 5/14/2010.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Method and system for protein purification.  Korea 10-2010-0045284, filing date 5/14/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Method and system for protein purification.  China 201010175478.X, filing date 5/14/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Pending.
  • Chang, M. D.-T., Sheu, C.-C.  Method and system for protein purification.  Canada, filing date 5/14/2010.  Priority date 05/15/2009, priority no. US11/070,271.  Pending.
  • 張大慈、許嘉欽  重組蛋白包含澱粉鍵結區域及其應用Recombinant protein comprising starch binding domain and use thereof。DIV中華民國專利099128708，申請日期：99年8月26日。優先權日：94年3月3日，優先權號：美國11/070,271。Pending。
  • 張大慈、方韶瓏、周維宜、林淑娟  用於胞內輸送之細胞穿透胜肽 Cell penetrating peptides for intracellular delivery。中華民國專利100116711，申請日期：100年5月12日。優先權日：99年5月14日，優先權號：美國US12/780,497。Pending。 
  • Chang, H.-T., Chang, M. D.-T., Hwang, C.-S.  Biomarker for amylotrophic lateral sclerosis and diagnosis kit and method used thereof.  US13/164,190, filing date 6/20/2011.  Pending.
  • 張顥騰、張大慈、黃啟訓  用於脊髓側索硬化症之生物標記、診斷套組及其方法 Biomarker for amylotrophic lateral sclerosis and diagnosis kit and method used thereof.中華民國專利100125320，申請日期：100年7月18日。優先權日：100年6月23日，優先權號：美國11/070,271。Pending。
  • Chang, M. D.-T., Chen, C.-J., Fang, S.-l. Kit and method of use of targeting peptide for diagnosis and therapy of cancer. US13/478,616, filing date 6/23/2012. Pending.
  • 張大慈、陳建榮、方韶瓏 靶向胜肽用於診斷及治療癌症之套組及方法 Kit and method of use of targeting peptide for diagnosis and therapy of cancer. 中華民國專利101118456，申請日期：101年5月24日。優先權日：101年5月23日，優先權號：美國US13/478,616。審查中。
  • Chang, M. D.-T., Fu, L.-S. Method of using heparin binding peptide for preventing or treating inflammatory syndrome. US61/698,835, filing date 9/10/2012. Pending.

Conference Presentation (2007-2013)

  • Wang, H.-Y., Pai, T.-W., Chang, H.-T., Lee, Y.-H., Chang, Y.-S., Fan, T.-c., Lin, S.-C., Chang, M. D.-T.* (2007)  Identification and characterization of novel transcription factor binding motif in the promoter of human ribonuclease.  Poster, the Fifth Asia-Pacific Bioinformatics Conference (APBC2007, January 15-17, 2007), Hong Kong, PRC.
  • Pai, T.-W., Chen, J.-M., Su, B.-H., Chang, M. D.-T., Chang, H.-T., Chou, W.-I (2007)  Protein Hierarchical Selection: An Information Portal for Multiple Protein Structural Alignment.  Poster, the Fifth Asia-Pacific Bioinformatics Conference (APBC2007, January 15-17, 2007), Hong Kong, PRC.
  • Chang, F.-Y., Chou, W.-I, Chang, M. D.-T.* (2007)  The role of asparagines in SBD from Rhizopus oryzae glucoamylase.  Poster, Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, R. O. C.
  • Shih, D.-F., Lin, S.-C., Jiang, T.-Y., Chang, M. D.-T.* (2007)  Expression and characterization of recombinant cathepsin S and inhibitor assay development.  Poster, Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, R. O. C.
  • Chen, B.-R., Lu, I.-C., Shiah, S.-G..*, Chang, M. D.-T.*, Wu, C.-W.* (2007)  Ax1 induces spermine/spermidine N1-Acetyltransferase through the PI3K/Akt pathway in cancer cell lines.  Poster, Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, R. O. C.
  • Chen, G.-Y., Chang, M. D.-T., Huang, K.-S., Chen, C.-Y., Hu, Y.-C. (2007)  Combination of trangential flow filtration and concanavalin A chromatography for the purification of baculoviral vector.  Poster, Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, R. O. C.
  • Ho, P.-C., Lin, S.-C., Chen, C.-M., Chang, M. D.-T.* (2007)  Protection of antibodies against recombinant envelope protein of white spot syndrome virus.  Poster, The Twenty second Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, R.O.C.
  • Chang, M. D.-T., Chang, H.-T., Tzou, W.-S., Liu, C.-H., Zhung, W.-J., Wang, H.-W., Chang, C.-T., Huang, R.-Y., Pai, T.-W. (2007)  Oral presentation, A database for prediction of unique peptide motifs as linear epitopes.  Oral presentation, International Symposium on Bioinformatics Research and Applications (ISBRA, May 6-10, 2007), Atlanta, Georgia, U. S. A.
  • Wang, H.-W., Chen, J.-M., Chou, W.-Y., Chang, M. D.-T., Pai, T.-W.  (2007) Ordered combinatorial feature selection: An information portal for multiple indexing sequence alighment.  Poster, International Symposium on Bioinformatics Research and Applications (ISBRA, May 6-10, 2007), Atlanta, Georgia, U. S. A.
  • Tung, J.-Y., Liu, Y.-Y., Chou, W.-I., Chang, F.-Y., Chang, M. D.-T., Y. J. Sun (2007)  Carbohydrate-binding of the starch binding domain of Rhizopus oryzae glucoamylase in complex with β-cyclodextrin and maltoheptaose.  The 12th Symposium on Recent Advances in Biophysics, Zhunan Town, Taiwan, R. O. C.  (Best poster award)
  • Fan, T.-c., Lin, S.-c., Chang, M. D.-T.* (2007) A Heparan Sulfate-Facilitated and Raft-Dependent Macropinocytosis of Eosinophil Cationic Protein.  Poster, FEBS2007, the 32nd FEBS Congress in Vienna (July 7-12, 2007), Vienna, Austria.
  • Lin, S.-C., Fan, T.-c., Chang, M. D.-T.* (2007) Characterization of heparan sulfate as a cell surface attachment molecule for human eosinophil ribonucleases.  Poster, FEBS2007, the 32nd FEBS Congress in Vienna (July 7-12, 2007), Vienna, Austria.
  • Chang, M. D.-T.*, Lin, S.-C. (2007) Novel endocytosis pathway of human toxins and the application in development of imaging peptide nanoparticle complex. 2007年兩岸清華大學奈米科技學術研討會，新竹市，中華民國。
  • Chang, M. D.-T.*, Chou, W.-I., Pai, T.-W., Lyu, P.-C., Sun, Y.-J., Liu, S.-H., Sheu, C.-C., Lin, Y.-C. (2007) Correlation and characterization of functions and secondary/tertiary structures of carbohydrate binding modules.  Oral presentation, the Third Symposium on the Alpha-Amylase Family (September 23-27, 2007), Smolenice Castle, Slovakia.
  • Lin, S.-C., Chou, W.-I., Sheu, C.-C., Chang, M. D.-T.* (2007) Stable linker peptides for recombinant fusion protein expression in E. coli.  Poster, the Third Symposium on the Alpha-Amylase Family (September 23-27, 2007), Smolenice Castle, Slovakia.
  • Liu, S.-H., Chou, W.-I., Lin, S.-C., Sheu, C.-C., Chang, M. D.-T.* (2007) Economic process model for high performance purification of recombinant protein comprising starch binding domain.  Poster, the Third Symposium on the Alpha-Amylase Family (September 23-27, 2007), Smolenice Castle, Slovakia.  (Third prize poster award)
  • Chou, W.-I., Chang, H.-T., Chang, M. D.-T.* (2007) Mapping key ligand bindings on carbohydrate binding modules with low sequence homology.  Poster, 2007 Symposium on host-microbes interactions (29-20 October 2007), Kuan-Shi, Hsinchu, Taiwan, R. O. C.
  • Fan, T.-c., Chang, M. D.-T.* (2007) A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein.  Poster, 2007 Symposium on host-microbes interactions (29-20 October 2007), Kuan-Shi, Hsinchu, Taiwan, R. O. C.
  • Lin, S.-C., Fan, T.-c., Lin, T.-W., Chang, M. D.-T.* (2007) Characterization of heparin-binding peptides from human eosinophil ribonucleases.  Poster, 2007 Symposium on host-microbes interactions (29-20 October 2007), Kuan-Shi, Hsinchu, Taiwan, R. O. C.
  • Chang, M. D.-T. (2007)  Structural and functional analyses of protease/protease inhibitors involved in tumor metastasis. Oral presentation, 2007 NHRI-NTHU Joint Research Conference, Zhunan Town, Taiwan, R. O. C.
  • Chang, H.-T., Liu, C.-H., Chang, M. D.-T., Pai, T.-W. (2008)  Estimation and extraction of predictive linear epitopes by mathematical morphology approaches. Poster, the Sixth Asia-Pacific Bioinformatics Conference (APBC2008, 15-18 January), Kyoto, Japan.
  • Chou, W.-I., Fan, T.-c., Pai, T.-W., Sun, Y.-J., Chang, F.-Y., Chang, H.-T., Lin, S.-C., Lin, Y.-C. Chang, M. D.-T.* (2008)  Mapping key ligand binding sites on carbohydrate binding modules with low sequence homology.  Poster, the Sixth Asia-Pacific Bioinformatics Conference (APBC2008, 15-18 January), Kyoto, Japan.
  • Fan, T.-c., Chang, H.-T., Chen, I.-W., Wang, H.-Y., Chang, M. D.-T.* (2008)  A heparan sulfate facilitated pathway for the internalization of eosinophil cationic protein through lipid raft-dependent macropinocytosis.  Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Liu, W.-T., Lin, S.-C., Chou, W.-I., Liu, T.-H., Pan, R.-L., Tzou, D.-L., Hua, T.-E., Chang, M. D.-T.* (2008)  Terminal charge pair and asparagine-aromatic motifs govern amyloid-like fibril formation of a starch binding domain.  Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Jiang, T.-Y., Chou, W.-I., Lin, S.-C., Chang, M. D.-T.* (2008)  The polar residues of SBD from Rhizopus oryzae glucoamylase play disruption role in starch-binding.  Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Lin, S.-C., Lin, T.-W., Fan, T.-c., Chang, M. D.-T.* (2008)  Characterization of heparin-binding peptides from human eosinophil ribonucleases.  Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Wang, H.-J., Lin, S.-C., Shih, D.-F., Chang, H.-T., Chang, M. D.-T.* (2008)  Expression and characterization of recombinant cathepsin S and inhibitor assay development.  Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Chao, C-C., Sun, F.-C., Wang, C.-H., Lo, C.-W., Chang, Y.-S., Chang, K.-C., Chang, M. D.-T., Lai, Y.-K. (2008)  Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells.  Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Lo, C.-W., Chang, Y.-S., Chao, C.-C., Chang, K.-C., Lin, C.-C., Huang, K.-L., Chang, M. D.-T.*, Lai Y.-K.* (2008)  The regulation of Hsp90 translation efficiency by 5-UTR sequence.   Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Chang, K.-C., Shu, C.-W., Lo, C.-W., Chao, C.-C., Chang, M. D.-T.*, Lai Y.-K.* (2008)  Eosinophil cationic protein-induced apoptosis is mediated by caspase-8 in BEAS-2B cells.  Poster, Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology (Jan 23-25, 2008) Kenting, Taiwan, R. O. C.
  • Chou, W.-Y., Chang, M. D.-T.*, Chang, H.-T., Chou, W.-I., Fan, T.-c. Tzou, W.-S., Pai, T.-W.* (2008)  Multiple anchored block sequence alignment based on short consensus motifs.  Poster, The 1st Japan-Taiwan Young Researchers Conference on Computational and Systems Biology (Mar 9-11, 2008) Hsinchu, Taiwan, R. O. C.
  • Wang, H.-Y., Pai, T.-W., Chou, W.-Y., Chang, M. D.-T.* (2008)  In silico and in vitro analyses of evolutionary- conserved sequence motifin primate genomes of eosinophil ribonucleases.  Poster, The 1st Japan-Taiwan Young Researchers Conference on Computational and Systems Biology (Mar 9-11, 2008) Hsinchu, Taiwan, R. O. C. (Best poster award)
  • Fang, S.-l., Fan, T.-c., Lin, S.-C., Hung, S.-C., Hsu, C.-Y., Chang, M. D.-T.* (2008) Characterization of molecular interactions between eosinophil cationic protein and heparin.  Poster, The Twenty third Joint Annual Conference of Biomedical Sciences (Mar 29-30, 2008), Taipei, Taiwan, R.O.C.
  • Lo, Y.-H., Liu, S.-H., Lin, S.-C., Chang, M. D.-T.* (2008) Improved secretory production of glucoamylase in Pichia pastoris by combination of genetic manipulations.  Poster, The Twenty third Joint Annual Conference of Biomedical Sciences (Mar 29-30, 2008), Taipei, Taiwan, R.O.C.
  • Wang, H.-Y., Chang, M. D.-T.* (2008)  Transcriptional regulation of eosinophil derived neurotoxin by MAZ and Sp1 is governed by a characteristic DNA sequence motif.  Poster, The Twenty third Joint Annual Conference of Biomedical Sciences (Mar 29-30, 2008), Taipei, Taiwan, R.O.C.
  • Liu, S.-H., Chou, W.-I., Lin, S.-C., Sheu, C.-C., Chang, M. D.-T.* (2008)  Using starch as a super affinity resin to purify recombinant protein-The ultimate low-cost process.  Poster, An International Symposium: Biotechnology for Better Crops, Energy and Health - ABRC 10th Anniversary (Apr. 29-May 1, 2008), Taipei, Taiwan, R. O. C.
  • Chang, M. D.-T.*, Liu, S.-H., Chou, W.-I., Lin, S.-C., Sheu, C.-C. (2008)  Using starch as a super affinity resin to purify recombinant protein -  The ultimate low-cost process.  Poster, BIO2008 International Convention (June 17-20, 2008), San Diego, CA, U. S. A.
  • Chang, M. D.-T.*, Chou, W.-I., Lin, S.-C. (2008)  Mapping key ligand binding sites on carbohydrate binding modules with low sequence homology.  Poster, the 33rd FEBS Congress & 11th IUBMB Conference (June 28 – July 3, 2008), Athens, Greece.
  • Lin, S.-C., Liu, W.-T., Chou, W.-I., Chang, M. D.-T.* (2008)  The carbohydrate binding module family 21 contains a unique segment directing nano fibril formation.  Poster, the 33rd FEBS Congress & 11th IUBMB Conference (June 28 – July 3, 2008), Athens, Greece.
  • Chou, W.-Y., Chou, W.-I., Pai, T.-W., Lin, S.-C., Chang, F.-Y., Sun, Y.-J., Tang, C.-Y., Chang, M. D.-T.* (2008)  Multiple sequence alignment for functional correlation among low similarity sequences.  Full paper, Third IAPR International Conference on Pattern Recognition in Bioinformatics (PRIB 2008, Oct. 15-17, 2008), Novotel Sr. Kilda, Melbourne, Australia.
  • Fang, S.-l., Fan, T.-c., Lin, S.-C., Chang, M. D.-T.* (2008)  Characterization of molecular interactions between eosinophil cationic protein and heparin sulfate.  Poster, The 20th FAOBMB Conference (Oct. 23-25, 2008), Taipei, Taiwan, R. O. C.
  • Chen, C.-M., Hsiao, M.-C., Pai, T.-W., Cheng, R., Tzou, W.-S., Chang, M. D.-T. (2008) Identification of SSR Regulators for Functional Gene Sets through Cross-Species Comparison.  Full paper, The 2nd International Symposium on Optimization and Systems Biology (OSB2008, Oct. 31-Nov. 3, 2008), Lijiang, China.
  • Chou, W.-Y., Chou, W.-I., Pai, T.-W., Lin, S.-C., Jiang, T.-Y., Tang, C.-Y., Chang, M. D.-T.* (2008) Weighted multiple sequence alignment among starch-binding carbohydrate binding modules for functional binding site analysis.  Poster, The 2nd Japan-Taiwan Young Researchers Conference on Computational and Systems Biology (TJYoung2, Nov. 4-6, 2008), Odaiba, Japan.
  • Chou, W.-I., Jiang, T.-Y., Tung, J.-Y., Lin, S.-C., Liu, S.-H., Sun, Y.-J.*, Chang, M. D.-T.* (2008) Dissecting the polysaccharide binding mechanism of starch-binding domain from Rhizopus oryzae glucoamylase.  Poster, 2008 NHRI-NTHU Joint Research Conference (Nov. 24, 2008), Zhunan Town, Taiwan, R. O. C.
  • Lin, S.-C., Liu, W.-T., Chou, W.-I., Liu, T.-H., Pan, R.-L., Chang, M. D.-T.* (2008) Identification and characterization of a novel fibril forming peptide in fungan starch binding domain.  Poster, 2008 NHRI-NTHU Joint Research Conference (Nov. 24, 2008), Zhunan Town, Taiwan, R. O. C.
  • Huang, R.-Y., Chang, H.-T., Lan, C.-Y., Pai, T.-W., Wu, C.-N., Ling, C.-M., Chang, M. D.-T.* (2008) Development and evaluation of a sensitive enzyme-linked oligonucleotide-sorbent assay for detection of polymerase chain reaction-amplified hepatitis C virus of genotypes 1 to 6.  Poster, 2008 NHRI-NTHU Joint Research Conference (Nov. 24, 2008), Zhunan Town, Taiwan, R. O. C.
  • Fang, S.-l., Fan, T.-c., Lin, S.-C., Chang, M. D.-T.* (2008)  Molecular interactions between human eosinophil cationic protein and heparin.  Poster, 2008 NHRI-NTHU Joint Research Conference (Nov. 24, 2008), Zhunan Town, Taiwan, R. O. C.
  • Wang, H.-C., Lin, S.-C., Lin, C.-C., Tsai, J.-Y., Huang, H.-M., Chang, W.-S., Chang, J.-Y., Chang, H.-T., Chang, M. D.-T.* (2008)  Human cathepsin S as a molecular target for tumor metastasis and novel inhibitor screening.  Poster, 2008 NHRI-NTHU Joint Research Conference (Nov. 24, 2008), Zhunan Town, Taiwan, R. O. C.
  • Chou, W.-I., Chou, W.-Y., Lin, S.-C., Jiang, T.-Y., C.-Y. Tang, Chang, M. D.-T.* (2008)  Functional Residue Prediction by Multiple Sequence Alignment for Carbohydrate Binding Modules.  Full paper, 8th Atlantic Symposium on Computational Biology and Genome Informatics (CBGI2008, Dec. 15-20), Shenzhen, PRC.
  • Chou, W.-Y., Chou, W.-I., Pai, T.-W., Lin, S.-C., Jiang, T.-Y., Chang, M. D.-T.* (2009)  Functional residue prediction by multiple sequence alignment for carbohydrate binding modules.  Poster, The seventh Asia Pacific Bioinformatics Conference (APBC2009, Jan. 13-16, 2009), Beijing, China.
  • Hsieh, C.-A., Lin, S.-C., Lin, I.-P., Chou, W.-I., Liu, S.-H., Huang, R.-Y., Ho, P.-C. Chang, M. D.-T.* (2009)  The application of CBM21 starch-binding domain for recombinant protein purification in E. coli and P. pastoris expression systems.  Poster, The Twenty forth Joint Annual Conference of Biomedical Sciences (Mar 21-22, 2009), Taipei, Taiwan, R.O.C.
  • Hsu, C.-y., Fang, S.-l., Fan, T.-c., Lin, S.-C., Chang, M. D.-T.* (2009)  The heparin binding motif on human eosinophil cationic protein.  Poster, The Twenty forth Joint Annual Conference of Biomedical Sciences (Mar 21-22, 2009), Taipei, Taiwan, R.O.C.
  • Wang, H.-C., Lin, S.-C., Lin, C.-C., Chang, M. D.-T.* (2009)  Human cathepsin S as a molecular target for tumor metastasis and novel inhibitor screening.  Poster, The Twenty forth Joint Annual Conference of Biomedical Sciences (Mar 21-22, 2009), Taipei, Taiwan, R.O.C.
  • Wang, H.-C., Lin, S.-C., Lin, C.-C., Tsai, R.-Y., Huang, H.-M., Chang, W.-S., Chang, J.-Y., Chang, W.-T., Chang, M. D.-T.* (2009)  Poster, Screening and identification of novel human cathepsin S inhibitors against tumor invasion and metastasis.  The 14th Taiwan Joint Cancer Conference (May 2-3, 2009), Taipei, Taiwan, R. O. C.
  • Tsai, M.-T., Chang, C.-F., Chang, M. D.-T., Chang, J.-Y., Uang, B.-J., Hsieh, H.-P. (2009)  Poster, Design and synthesis of novel cathepsin S inhibitors against cancer migration and invasion.  The 14th Taiwan Joint Cancer Conference (May 2-3, 2009), Taipei, Taiwan, R. O. C.
  • Liu, K.-C., Kuo, C.-C., Hung, I.-W., Lai, W.-Y., Lin, C.-C., Chang, M. D.-T., Lyu, P.-C., Uang, B.-J., Chang, J.-Y., (2009)  Poster, A novel alpha-ketone amide compound CCL-ymc-7K with inhibitory activity on cathepsin S displays anti-angiogenesis potential.  The 14th Taiwan Joint Cancer Conference (May 2-3, 2009), Taipei, Taiwan, R. O. C.
  • Chen, R.-C., Lin, C.-C., Wang, H.-C., Lin, S.-C., Chang, M. D.-T., Lin, S.-C., Chiang, C.-H., Lee, P.-Y., Chang, W.-H., Kuo, C.-C., Liu, K.-C., Chang, J.-Y., (2009)  Poster, Synthesis of alpha-ketone amides as cathepsin S inhibitors.  The 14th Taiwan Joint Cancer Conference (May 2-3, 2009), Taipei, Taiwan, R. O. C.
  • Chou, W.-Y., Chou, W.-I., Pai, T.-W., Lin, S.-C., Jiang, T.-Y., Tang, C.-Y., Chang, M. D.-T.* (2009)  Poster, Conserved functional residue detection on carbohydrate binding modules with low sequence identity.  The Society of Chinese Bioscientists in America 12th International Symposium (12th SCBA, June 14-18, 2009), Taipei, Taiwan, R. O. C.
  • Huang, R.-Y., Lin, S.-C., Chou, W.-I., Liu, S.-H., Hsieh, C.-A., Chang, M. D.-T.* (2009)  Poster, New insights into CBM21 starch-binding domain from an economic recombinant protein process model.  The Society of Chinese Bioscientists in America 12th International Symposium (12th SCBA, June 14-18, 2009), Taipei, Taiwan, R. O. C.
  • Jiang, T.-Y., Chou, W.-I., Lin, S.-C., Chang, M. D.-T.* (2009)  Poster, Functional characterization of interaction between starch binding domain and ligands. The Society of Chinese Bioscientists in America 12th International Symposium (12th SCBA, June 14-18, 2009), Taipei, Taiwan, R. O. C.
  • Fang, S.-l., Fan, T.-c., Hsu, C.-y., Hung, T.-j., Chang, M. D.-T.* (2009)  Poster, The functional roles of heparan sulfate binding motif of human eosinophil cationic protein.  The Society of Chinese Bioscientists in America 12th International Symposium (12th SCBA, June 14-18, 2009), Taipei, Taiwan, R. O. C.
  • Lin, S.-C., Huang, H.-R., Chou, W.-I., Liu, S.-H., Sheu, C.-C., Chang, M. D.-T.* (2009)  Poster, Protein Purification by Starch Affinity Tag.  The Bioprocessing Summit (Aug. 24-27, 2009), Cambridge, U. S. A.
  • Tseng, L.-J., Kao, B.-T., Lin, W.-Y., Chang, M. D.-T., Pai, T.-W., Hunag, Y.-C. and Chang, H.-T. (2009) The Potential Chinese Herbs for Inhibiting Cytotoxicity of Eosinophil Cationic Protein.  Oral presentation.  The Third International Symposium on Optimization and Systems Biology (OSB 2009, Sep. 20-22, 2009), Zhangjiajie, Hunan, China.
  • Fang, S.-l., Hsu, C.-y., Lin, T.-w., Hung, T.-J., Chang, M. D.-T.* (2009)  Functional characterization and molecular mechanisms of eosinophil cationic protein-heparin interaction.  The Third International Symposium on Bio-Inspired Engineering (ISBIE-2009, Oct. 21-23), Taipei, Taiwan, R. O. C.
  • Chou, W.-Y., Chou, W.-I., Lin, S.-C., Huang, R.-Y., Jiang, T.-Y., Chang, H.-T., Chen, C.-J., Wu, C.-M., Tang, C.-Y., Chang, M. D.-T.* (2009)  Biological Feature Incorporated Alignment for Cross Species Analysis on Carbohydrate Binding Modules.  Poster, IEEE International Conference on Bioinformatics & Biomedicine (BIBM2009, Nov. 1-4, 2009), Washington D. C., U. S. A.
  • Fang, S.-l., Hsu, C.-y., Fan, T.-c., Lin, L.-Y., Chang, M. D.-T.* (2009)  New function of heparin sulfate binding motif of human eosinophil cationic protein.  Biotechnology Taiwan 2009 (Nov. 6-8), Taipei, Taiwan, R. O. C.
  • Lin, S.-C., Chou, W.-I., Lee, Y.-C., Chang, M. D.-T.* (2009)  Molecular recognition study of starch binding domain.  Poster, 2009 Annual Meeting of the Society for Glycobiology (Nov. 12-15, 2009), San Diego, U. S. A.
  • Wu, W.-S., Fang, S.-l., Hsu, C.-y., Lin, T.-w., Hung, T.-J., Lai, Y.-K., Chang, M. D.-T.* (2009)  Functional characterization and molecular mechanisms of eosinophil cationic protein-heparin interaction.  Poster, 2009 NHRI-NTHU Joint Research Conference (Nov. 16, 2009), Zhunan Town, Taiwan, R. O. C.
  • Jiang, T.-Y., Chou, W.-I., Lin, S.-C., Chang, M. D.-T.* (2009)  Starch binding domain of Rhizopus oryzae possess disruptive ability for amylase.  Poster, 2009 NHRI-NTHU Joint Research Conference (Nov. 16, 2009), Zhunan Town, Taiwan, R. O. C.
  • Low, E.-L., Lo, Y.-H., Liu, S.-H., Chang, M. D.-T.* (2009)  Study of recombinant Tachypleus tridentatus plasma lectin for lipopolysaccharide detection.  Poster, 2009 NHRI-NTHU Joint Research Conference (Nov. 16, 2009), Zhunan Town, Taiwan, R. O. C.
  • Hung, T.-J., Fang, S.-l., Chang, M. D.-T.* (2009)  Molecular interaction between ECP and heparin.  Poster, 2009 NHRI-NTHU Joint Research Conference (Nov. 16, 2009), Zhunan Town, Taiwan, R. O. C.
  • Chang, H.-T., Chao, C.-H., Lin, Y.-F., Tseng, L.-J., Pai, T.-W., Shih, T.-H., Chang, M. D.-T., Tsai, P.-W. (2010)  Prediction of regulatory molecules for enhancement of EGFR overexpression triggered by signal peptide of ribonuclease 3.  Full paper, Third International Workshop on Intelligent Informatics in Biology and Medicine (IIBM2010, Feb. 12-15, 2010), Krakow, Poland.
  • Chang, M. D.-T. (2010)  Signature characterization from protein families with low sequence identity.  Oral presentation.  Deakin Bioinformatics Symposium 2010 (Feb. 9, 2010), Melbourne, Australia.
  • Hwang, C.-S., Wu, Y.-C., Chang, H.-T.*, Chang, M. D.-T.* (2010)  Domain specific heat shock protein monoclonal antibodies for the diagnosis and evaluation of motor neuron disease.  Poster, 2010 Taiwan Neurology Society Annual Meeting (May 1-2, 2010), Taipei, Taiwan, R. O. C.  (Best poster award).
  • Chen, W.-T., Lin, Y.-L., Chien, C.-F., Chang, M. D.-T., Chiang, H.-W. D., Wang, W.-C. (2010)  Implementation of University-Industry Collaboration at NTHU in Taiwan.  Full paper.  International Conference on Engineering Education and Research for Society (ICEE-2010, July 18-22), Gliwice, Poland.
  • Chuang, C.-S., Chen, C.-C., Pai, T.-W., Chang, H.-T., Chang, M. D.-T.* (2010)  Functional conservation and gene expression for cross-species HIF pathway.  The Forth International Symposium on International Conference on Computational Systems Biology (ISB 2010, Sep. 9-11, 2010), Suzhou, China.
  • Chen, C.-J., Low, E.-L., Chou, W.-I., Chang, M. D.-T.* (2010)  Application of starch binding domain in protein purification and immobilization.  The Forth Symposium on the Alpha-Amylase Family (September 26-30, 2010), Smolenice Castle, Slovakia.
  • Chou, W.-Y., Chou, W.-I., Pai, T.-W., Lin, S.-C., Jiang, T.-Y., Tang, C.-Y., Chang, M. D.-T.* (2010)  Ligand-binding residue prediction for carbohydrate-binding modules by feature-incorporated alignment.  Oral presentation.  The Forth Symposium on the Alpha-Amylase Family (September 26-30, 2010), Smolenice Castle, Slovakia.
  • Jiang, T.-y., Chou, W.-I., Lin, S.-C., Chang, M. D.-T.* (2010)  The model for disrupting ultrastructure of amylase without hydrolysis by RoSBD.  The Forth Symposium on the Alpha-Amylase Family (September 26-30, 2010), Smolenice Castle, Slovakia.
  • Fang, T.-W., Chou, W.-I., Ng, S.-K., Chang, M. D. T.* (2010)  Multivalent protein design of starch binding domain by molecular engineering.  Poster, 2010 NHRI-NTHU Joint Research Conference (Dec. 13, 2010), Zhunan Town, Taiwan, R. O. C.
  • Chen, C.-J., Chou, W.-I., Hsieh, C.-A., Ng, S.-K., Mao, L.-C., Low, E.-L., Chang, M. D.-T.* (2010)  Starch binding domain for molecular design of recombinant proteins.  Poster, 2010 NHRI-NTHU Joint Research Conference (Dec. 13, 2010), Zhunan Town, Taiwan, R. O. C.
  • Ci, Y.-P., Lee, Y.-C., Chou, W.-I., Jiang, T.-y. Chang, M. D.-T.* (2010)  Identification of the binding affinity between glycans and Rhizopus oryzae starch binding domain.  Poster, 2010 NHRI-NTHU Joint Research Conference (Dec. 13, 2010), Zhunan Town, Taiwan, R. O. C.
  • Jiang, T.-y., Chou, W.-I., Chang, M. D.-T.* (2010)  Functional roles of unique polyN loops of starch binding domain in ligand binding and amylose ultrastructure disruption.  Poster, 2010 NHRI-NTHU Joint Research Conference (Dec. 13, 2010), Zhunan Town, Taiwan, R. O. C.
  • Chang, H.-H., Chen, S.-L., Chen, T.-Y., Fang, S.-l., Hsu, C.-y., Lyu, P.-C., Chang, M. D.-T.* (2010) Characteristic sequences in eosinophil cationic protein for binding and endocytosis to bronchial epithelial cells.  Poster, 2010 NHRI-NTHU Joint Research Conference (Dec. 13, 2010), Zhunan Town, Taiwan, R. O. C.
  • Fang. S.-l., Hung, T.-J., Lin, L.-Y., Chang, M. D.-T.* (2010)  A novel cell penetrating peptide for intracellular delivery of proteins and peptides.  Poster, 2010 NHRI-NTHU Joint Research Conference (Dec. 13, 2010), Zhunan Town, Taiwan, R. O. C.
  • Hung, T.-J., Lee, Y.-C., Fang, S.-l., Chang, M. D.-T.* (2010)  Molecular interaction between cell surface glycosaminoglycans and heparin binding peptides of human eosinophil cationic protein.  Poster, 2010 NHRI-NTHU Joint Research Conference (Dec. 13, 2010), Zhunan Town, Taiwan, R. O. C.
  • Lin, Y.-C., Huang, H.-T., Chang, H.-T., Chang, M. D.-T. Pai, T.-W. (2010)  Linear B-cell epitope prediction based on support vector machine and propensity scale method.  Poster, 2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM2010, Dec. 18-21, 2010), Hong Kong, China.
  • Hsin-Wei Wang1, Wei-Kuo Wu, Tun-Wen Pai, Yi-Ping Phoebe Chen, Margaret D.-T. Chang (2011)  Impact of complex formation on predicting conformational epitopes.  Oral presentation.  The second IASTED International Conference on Computational Bioscience (CompBio 2011, Jul. 11-13), Cambridge, UK.
  • Tsai, Y.-L., Wang, H.-W., Pai, T.-W., Chang, M. D.-T. (2011)  Deformation invariant local descriptors for protein surface comparison.  Oral presentation. The second IASTED International Conference on Computational Bioscience (CompBio 2011, Jul. 11-13), Cambridge, UK.
  • Jiang, T.-Y., Chou, W.-Y., Ng, S.-K., Ci, Y.-P., Low, E.-L., Chang, M. D.-T.* (2011)  Amylose structure alteration by fungal starch binding domain.  Poster, The Society of Chinese Bioscientists in America 13rd International Symposium (13rd SCBA, Jul. 25-29, 2011), Guangzhou, China.
  • Chen, C.-J., Fang, S.-l., Hung, T.-J., Chang, H.-h., Lien, P.-C., Tseng, T.-Y., Chang, M. D.-T.* (2011)  Novel cell-penetrating peptide derived from human eosinophil cationic protein.  Poster, The Society of Chinese Bioscientists in America 13rd International Symposium (13rd SCBA, Jul. 25-29, 2011), Guangzhou, China.
  • Liu, Y.-S., Chao, C.-H., Chang, H.-T., Chang, M. D.-T., Pai, T.-W. (2011) Analysis of gene expression profile triggered by signal peptide of eosinophil cationic protein.  Poster, 5th IEEE International Conference on Systems Biology (ISB2011, Sep. 2-4, 2011), Zhuhai, China.
  • Lo, Y.-T., Shih, T.-H., Liu, H.-J., Pai, T.-W., Chang, M. D.-T. (2011)  Cross-species identification of hydroxylation sites for ARD and FIH interaction.  Poster, 5th IEEE International Conference on Systems Biology (ISB2011, Sep. 2-4, 2011), Zhuhai, China.
  • Chang, M. D.-T. (2011)  A model for NTHU academic-biotech industry collaboration.  Invited speech.  2011 Taiwan-US S&T Workshop for International Collaborative Research (Nov. 14-15, 2011), Taoyuan, Taiwan, R. O. C.
  • Lien, P.-C., Kuo, P.-H., Fang, S.-l., Wu, W.-H., Punde, T.-H., Shih, P.-C., Liu, C.-H., Chang, M. D.-T.* (2011)  Microenvironmental change and overexpression of inflammatory cytokine under regulation of eosinophil cationic protein and interleukin-17.  Poster, 2011 NHRI-NTHU Joint Research Conference (Nov. 27, 2011), Zhunan Town, Taiwan, R. O. C.  Best Poster Award.
  • Hwang, C.-S., Tsai, P.-W., Chang, M. D.-T.*, Chang, H.-T.* (2011)  Elevated serum levels of autoantibodies against heat shock proteins in patients with amyotrophic lateral sclerosis.  22nd International Symposium on ALS/MND (Nov. 30 – Dec. 2, 2011), Sydney, Australia.
  • Chang, M. D.-T. (2011)  From starch-binding protein to cost-effective recombinant proteins-A story about academic industry collaboration between NTHU and Simpson Biotech Co.  Invited speech.  2011 BIO Business Forum (Dec. 16-17, 2011), Hong Kong, China.
  • Lien, P.-C., Kuo, P.-H., Fang, S.-l., Wu, W.-H., Punde, T. H., Shih, P.-C., Liu, C.-H., Chang, M. D.-T.* (2012)  In vitro microenvironmental change-induced inflammatory process under stimulation of eosinophil cationic protein and interleukin-17.  Symposium of Engineering Medicine and Biology Applications & International Workshop on Bio-inspired Systems and Prothetic Devices. (SEMBA Feb. 11-13, 2012), Hsinchu, Taiwan.
  • Lien, P.-C., Chang, M. D.-T.* (2012)  Cytokine-induced lung inflammation and microenvironmental change under regulation of eosinophil cationic protein.  Poster, Tsing Hua 1+1 Cross Strait University Graduate Forum (Mar. 10-11, 2012), Hsinchu, Taiwan, R. O. C.  Best Poster Award.
  • Fang, S.-l., Chang, M. D.-T.* (2012)  A heparan sulfate binding-dependent cell penetrating peptide derived from human eosinophil cationic protein.  Poster, Tsing Hua 1+1 Cross Strait University Graduate Forum (Mar. 10-11, 2012), Hsinchu, Taiwan, R. O. C.  Best Poster Award.
  • Jiang, T.-Y., Chang, M. D.-T.* (2012)  Amylose structure disruption by a fungal starch binding domain with unique binding clamps.  Oral presentation, Tsing Hua 1+1 Cross Strait University Graduate Forum (Mar. 10-11, 2012), Hsinchu, Taiwan, R. O. C.  Best Research Award.
  • Chen, C.-J., Chang, M. D.-T.* (2012)  Identification and design of a novel heparin binding protein derived from human eosinophil cationic protein.  Oral presentation, Tsing Hua 1+1 Cross Strait University Graduate Forum (Mar. 10-11, 2012), Hsinchu, Taiwan, R. O. C. 
  • Ng, S.-K., Chang, M. D.-T.* (2012)  Molecular design of starch binding domain of Rhizopus oryzae glucoamylase.  Poster, Tsing Hua 1+1 Cross Strait University Graduate Forum (Mar. 10-11, 2012), Hsinchu, Taiwan, R. O. C. 
  • Kuo, P.-H., Chang, M. D.-T.* (2012)  A novel heparin-binding cell penetrating peptide for cargo delivery.  Poster, Tsing Hua 1+1 Cross Strait University Graduate Forum (Mar. 10-11, 2012), Hsinchu, Taiwan, R. O. C.
  • Huang, H.-T., Chang, M. D.-T.* (2012)  An interaction model between glycans and starch binding domain of Rhizopus oryzae glucoamylase.  Poster, Tsing Hua 1+1 Cross Strait University Graduate Forum (Mar. 10-11, 2012), Hsinchu, Taiwan, R. O. C.
  • Fang, S.-l., Chen, C.-J., Hung, T.-J., Chang, M. D. T.* (2012)  A heparan sulfate binding-dependent cell penetrating peptide derived from human eosinophil cationic protein.  Poster, The Twenty Seventh Joint Annual Conference of Biomedical Sciences (Mar. 17-18, 2012), Taipei, Taiwan, R.O.C.
  • Chen, C.-J., Hung, T.-J., Fang, S.-l., Chang, P.-L., Chang, M. D.-T.* (2012)  Identification and design of a novel heparin binding peptide derived from human eosinophil cationic protein.  Poster, The Twenty Seventh Joint Annual Conference of Biomedical Sciences (Mar. 17-18, 2012), Taipei, Taiwan, R.O.C.
  • Jiang, T.-Y., Chou, W.-I., Ng, S.-K., Ci, Y.-P., Chou, W.-Y., Low, E.-L., Chang, M. D.-T.* (2012)  Amylose structure disruption by a fungal starch binding domain.  Poster, The Twenty Seventh Joint Annual Conference of Biomedical Sciences (Mar. 17-18, 2012), Taipei, Taiwan, R.O.C.
  • Ng, S.-K., Fang, T.-W., Chou, W.-I., Chang, M. D.-T.* (2012)  Molecular design of starch binding domain of Rhizopus oryzae glucoamylase.  Poster, The Twenty Seventh Joint Annual Conference of Biomedical Sciences (Mar. 17-18, 2012), Taipei, Taiwan, R.O.C.
  • Lien, P.-C., Kuo, P.-H., Fang, S.-l., Wu, W.-H., Punde, T.-H., Liu, C.-H., Chang, M. D.-T.* (2012)  Cytokine-induced lung inflammation and microenvironmental change under regulation of eosinophil cationic protein.  Poster, The Twenty Seventh Joint Annual Conference of Biomedical Sciences (Mar. 17-18, 2012), Taipei, Taiwan, R.O.C.
  • Kuo, P.-H., Fang, S.-l., Chen, C.-J., Chang, P.-L., Chang, M. D.-T.* (2012)  A novel heparin-binding cell penetrating peptide for cargo delivery.  Poster, The Twenty Seventh Joint Annual Conference of Biomedical Sciences (Mar. 17-18, 2012), Taipei, Taiwan, R.O.C.
  • Huang, H.-T., Ci, Y.-P., Fang, T.-W., Chou, W.-I., Chou, W.-Y., Chang, M. D.-T.* (2012)  An interaction model between glycans and starch binding domain of Rhizopus oryzae glucoamylase.  Poster, The Twenty Seventh Joint Annual Conference of Biomedical Sciences (Mar. 17-18, 2012), Taipei, Taiwan, R.O.C.
  • Chang, M. D.-T. (2012)  Starch binding domain-from basic science to biotech development.  Invited speech.  The 2012 Inter-Tsinghua Biomedical Forum (Apr. 1, 2012), Beijing, China.
  • Ng, S.-K., Huang, H.-T., Lee, Y.-C., Fang, T.-W., Jiang, T.-Y., Ci, Y.-P., Chou, W.-I., Chang, M. D.-T.* (2012)  Molecular design and functional analysis of starch binding domain of Rhizopus oryzae glucoamylase.  Poster, Experimental Biology 2012 (EB2012, Apr. 21-25, 2012), San Diego, U. S. A.
  • Chen, C.-J., Fang, S.-l., Hung, T.-J., Kuo, P.-H., Lien, P.-C., Chang, P.-L., Chang, M. D.-T.* (2012)  Novel cell-penetrating peptide derived from human eosinophil cationic protein.  Poster, Experimental Biology 2012 (EB2012, Apr. 21-25, 2012), San Diego, U. S. A.
  • Lien, P.-C., Chen, C.-J., Kuo, P.-H., Pai, T.-W., Chang, H.-H., Chang, M. D.-T.* (2012)  In silico prediction and in vitro characterization of unique function of human RNase3.  Oral Presentation, Fifth International Workshop on Intelligent Informatics in Biology and Medicine (IIBM 2012, Jul. 4-6, 2012), Palermo, Italy.
  • Kuo, P.-H., Chen, C.-J., Lien, P.-C., Pai, T.-W., Chang, H.-H., Fang, S.-l., Chang, M. D.-T.* (2012)  Molecular identification of a unique heparin binding motif derived from human RNase3.  Oral Presentation, Fifth International Workshop on Intelligent Informatics in Biology and Medicine (IIBM 2012, Jul. 4-6, 2012), Palermo, Italy.
  • Shih, T.-H., Chen, C.-M., Liu, Z.-L., Pai, T.-W., Chang, M. D.-T. (2012) Pathway and GO variation analysis based on RNA-seq accounts. Oral Presentation, 6th IEEE International Conference on Systems Biology (ISB2012, Aug, 18-20, 2012), Xi-An, China.
  • Punde, T.-H., Wu, W.-H., Lien, P.-C., Chang, M. D.-T., Lee, K.-Y., Kuo, H.-P., Shih, P.-C., Liu, C.-H. (2012) A bronchial epithelium-mimetic microfluidic chip system for investigating the microenvironmental change-induced inflammatory processes. Poster, The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Micro TAS, Oct. 28 – Nov. 1, 2012), Okinawa, Japan.
  • Tsai, K.-C., Kuo, P.-H., Chen, C.-J., Chang, P.-L, Chang, M. D.-T* (2012) Characterization of glycosaminoglycan binding peptide and its application for intracellular targeting. Poster, 2012 NHRI-NTHU Joint Research Conference (Nov. 26, 2012), Zhunan Town, Taiwan, R. O. C.
  • Lien, S.-C., Chang, M. D.-T., Chang, J.-Y., Chiu, C.-C. (2012) Laminar shear shtress induced autophagy and apoptosis of cancer cells: Roles of bone morphogenetic protein receptor and Smad1/5. Poster, 2012 NHRI-NTHU Joint Research Conference (Nov. 26, 2012), Zhunan Town, Taiwan, R. O. C.
  • Chang, M. D.-T. (2012) Innovative biotechnology developed at NTHU College of Life Science. Taiwan Junior Chamber International Worldwide Federation for Young Leaders and Entrepreneurs (JCI2012, Nov. 19-23, 2012).
  • Chuang, F.-Y., Ko, Y.-C., Chen, Y.-L., Tsai, W.-H., Chen, Y.-R., Chang, M. D.-T., Lin, S.-F. (2012) Characterization of FGFR3-TACC3 gene fusion on Taiwanese oral cancer cells. Poster, 2012 NHRI-NTHU Joint Research Conference (Nov. 26, 2012), Zhunan Town, Taiwan, R. O. C.
  • Fang, S.-l., Chen, C.-J., Hung, T.-J., Chang, P.-L., Chang, M. D.-T.* (2012) A novel glycosaminoglycan binding peptide for intracellular delivery and tissue targeting. Poster, The Taiwan Society for Biochemistry and Molecular Biology 2012 TSBMB Conference in Huisun (Dec. 6-8, 2012), Taichung, Taiwan.
  • Chen, C.-J., Kuo, P.-H., Chang, P.-L., Chang, Z.-L., Chang, M. D.-T.* (2012) A novel cancer targeting glycosaminoglycan binding peptide derived from human eosinophil cationic protein. Poster, The Taiwan Society for Biochemistry and Molecular Biology 2012 TSBMB Conference in Huisun (Dec. 6-8, 2012), Taichung, Taiwan.
  • Hung, T.-J., Lee, Y.-C., Cheng, W.-C., Chang, M. D.-T.* (2012) Characterization of ligand binding properties of novel glycosaminoglycan binding peptide employing quartz crystal microbalance. Poster, The Taiwan Society for Biochemistry and Molecular Biology 2012 TSBMB Conference in Huisun (Dec. 6-8, 2012), Taichung, Taiwan.
  • Jiang, T.-Y., Yang, C.-M., Chang, M. D.-T.* (2012) A novel application of fungal starch binding domain to expression and purification of human glycoprotein. Poster, The Taiwan Society for Biochemistry and Molecular Biology 2012 TSBMB Conference in Huisun (Dec. 6-8, 2012), Taichung, Taiwan.
  • Lee, C.-Y., Chou, T.-T., Chang, M. D.-T., Hsieh, Y.-J. (2013) Functional magnetic nanoparticles based electrochemical biosensor for detection of an asthma biomarker. Pittcon Conference & Exp 2013 (Pittcon 2013, Mar. 17-21, 2013), Philadelphia, PA, U. S. A.
  • Fang, S.-l., Fan, T.-c., Fu, H.-W., Chen, C.-J., Hwang, C.-S., Hung, T.-J., Lin, L.-Y., Chang, M. D.-T.* (2013) A novel cell-penetrating peptide derived from human eosinophil cationic protein. Oral presentation, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Jiang, T.-Y., Ci, Y.-P., Chou, W.-I., Lee, Y.-C., Sun, Y.-J., Chou, W.-Y., Li, K.-M., Chang, M. D.-T.* (2013) Disruption of amylase helical structure by Rhizopus oryzae starch binding domain with unique dual ligand binding clamps. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Hung, T.-J., Lee, Y.-C., Chang, M. D.-T.* (2013) Characterization of ligand binding properties of a novel cell penetrating peptide employing quartz crystal microbalance. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Chen, C.-J., Chang, Z.-L., Chang, P.-L., Kuo, P.-H., Chang, M. D.-T.* (2013) A novel glycosaminoglycan binding peptide for epithelial cancer targeting. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Kuo, P.-H., Fang, S.-l., Chen, C.-J., Chang, P.-L., Chang, M. D.-T.* (2013) Intracellular and in vivo biodistribution of a glycosaminoglycan-binding cell penetrating peptide. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Chen, T.-Y., Fang, S.-l., Fu, L.-s., Wu, Y.-R., Chang, M. D.-T.* (2013) A novel cell penetrating peptide for attenuation of house dust mite-induced asthma. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Chang, T.-H., Chang, H.-H., Lien, P.-C., Fang, S.-l., Chang, M. D.-T.* (2013) A novel cell penetrating peptide for liposomal drug delivery. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Huang, Y.-T., Ng, S.-K., Lin, Y.-C., Yang, C.-M., Chang, M. D.-T.* (2013) Expression and purification of recombinant cell penetrating peptides employing starch binding domain. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.
  • Yang, C.-M., Jiang, T.-Y., Ng, S.-K., Chang, M. D.-T.* (2013) Expression and purification of recombinant alpha-1-acid glycoprotein employing starch binding domain. Poster, The Twenty Eighth Joint Annual Conference of Biomedical Science (Mar. 23-24, 2013), Taipei, Taiwan, R.O.C.