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Recent Publications (2013-2016)

  1. Kun-Mou Li, Craig Wilkinson, Juho Kellosalo, Jia-Yin Tsai, Tommi Kajander, Lars Jeuken, Yuh-Ju Sun*, and Adrian Goldman* “Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism” Nature Communications (2016), 7:13596
  2. Ming-Yang Chang, Yi-Chuan Cheng, Shen-Hsing Hsu, Tsu-Lin Ma, Li-Fang Chou, Hsiang-Hao Hsu, Ya-Chung Tian, Yung-Chang Chen, Yuh-Ju Sun, Cheng-Chieh Hung, Rong-Long Pan and Chih-Wei Yang (2016). “Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae. ” Scientific Reports, 6:27838 | DOI: 10.1038/srep27838.
  3. Vankadari Naveen, Chen-Hsi Chu, Bo-Wei Chen, Yen-Chun Tsai, Chwan-Deng Hsiao and Yuh-Ju Sun* (2016) “Helicobacter pylori cell binding factor 2: Insights into domain motion” Journal of Structural Biology 194, 90–101
  4. Shen-Hsing Hsu, Yueh-Yu Lo, Tseng-Huang Liu, Yih-Jiuan Pan, Yun-Tzu Huang, Yuh-Ju Sun, Cheng-Chieh Hung, Fan-Gang Tseng, Chih-Wei Yang, and Rong-Long Pan (2015). “Substrate Induced Changes in Domains Interaction of Vacuolar H+-Pyrophosphatase” J Biol Chem. 290, 1197-1209.
  5. Bo-Wei Chen, Ming-Hsing Lin, Chen-Hsi Chu, Chia-En Hsu, and Yuh-Ju Sun* (2015) “Insights into ParB spreading from the complex structure of Spo0J and parS” Proc. Natl. Acad. Sci. USA 112 (21), 6613-6618
  6. Jia-Yin Tsai, Juho Kellosalo, Yuh-Ju Sun* and Adrian Goldman* (2014) “Proton/sodium pumping pyrophosphatases: the last of the primary ion pumps” Current Opinion in Structural Biology 27:38–47
  7. Chu, CH, Li, KM, Lin, SW, Chang, M DT, Jiang, TY, and Sun, YJ* (2014) “Crystal Structures of Starch Binding Domain from Rhizopus oryzae Glucoamylase in Complex with Isomaltooligosaccharide: Insights into Polysaccharide Binding Mechanism of CBM21 Family” Proteins: Structure, Function, and Bioinformatics 82, 1079-1085.
  8. Yu-Jung Chang, Kuan-Wei Chen, Ching-Jen Chen, Ming-Hsing Lin, Yuh-Ju Sun, Jia-Lin Lee, Ing-Ming Chiu, Linyi Chen (2014) “SH2B1b Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation” Molecular and Cellular Biology V34 p. 1003–1019
  9. Tsung-Fu Yu, Manuel Maestre-Reyna, Chia-Yun Ko, Tzu-Ping Ko, Yuh-Ju Sun, Tsai-Yun Lin, Jei-Fu Shaw*, Andrew H.-J. Wang (2014) “Structural Insights of the ssDNA Binding Site in the Multifunctional Endonuclease AtBFN2 from Arabidopsis thaliana” PLoS One. 9(8): e105821
  10. Lin, MH, Chang, YC, Hsiao, CD, Huang, SH, Wang, MS, Ko, YC, Yang CW and Sun, YJ* (2013). “LipL41, a Hemin Binding Protein from Leptospira santarosai Serovar Shermani” PLoS One, 12;8(12):e83246

Publication (2008-2013)

  1. Huang, YT, Liu TH, Lin, SM, Chen, YW, Pan, YJ, Lee, CH, Sun, YJ, Tseng, FG, Pan, RL. (2013). Squeezing at Entrance of Proton Transport Pathway in Proton-translocating Pyrophosphatase upon Substrate Binding. J Biol Chem. 288:19312-19320.
  2. Lo, YY, Hsu, SH, Ko, YC, Hung, CC, Chang, MY, Hsu, HH, Pan, MJ, Chen, YW, Lee, CH, Tseng FG, Sun, YJ, Yang, CW, Pan, RL. (2013) Essential calcium binding cluster of Leptospira LipL32 for inflammatory responses through the Toll-like receptor 2 pathway. J Biol Chem.88:12335-44
  3. Lin, S.-M. Tsai, J.-Y., Hsiao, C.-D., Huang, Y.-T., Chiu, C.-L., Liu, M.-H. Tung, J.-Y., Liu, T.-H., Pan, R.-L. & Sun Y.-J.* (2012) Crystal Structure of a Membrane-embedded H+-translocating Pyrophosphatase Nature 484, 399-403.
  4. Chu, Chen-His, Liu, Mu-Hsuan, Chen, Pin-Chen, Lin, Ming-Hsing, Li, Yi-Chuan, Hsiao, Chwan-Deng and Sun, Yuh-Ju* (2012) Crystal structures of Helicobacter pylori uridylate kinase: insight into the product UDP release Acta Cryst D. V.68, 773-783.
  5. Chang, Y.-W., Lin, T.-W., Li, Y.-C., Huang, Y.-S., Sun, Y.-J. and Hsiao, C.-D. (2012) Interaction Surface and Topology of Get3/Get4/Get5, a Complex Involved in Targeting Tail-Anchored Proteins to the Endoplasmic Reticulum. J. Biol. Chem. 287(5):4783-89.
  6. Jiang, TY, Ci, YP, Chou, WI, Lee, YC, Sun, YJ, Chou, WY, Li, KM, Chang, MD.(2012) “Two unique ligand-binding clamps of Rhizopus oryzae starch binding domain for helical structure disruption of amylose.” PLoS One. 2012;7(7):e41131
  7. Lo, Y.-H., Liu, S.-W., Sun, Y.-J., Li, H.-W and Hsiao, C.-D. (2011) Mutations altering interplay of GkDnaC helicase to DNA reveal an insight into helicase function and unwinding mechanism. PLoS One. 6(12) e29016
  8. Tung, J-Y, Yang, C.-W., Chou, S.-W., Lin, C.-C. and Sun, Y.-J.* Calcium Binds to LipL32, a Lipoprotein from Pathogenic Leptospira, and Modulates Fibronectin Binding J. Biol. Chem. (2010) 285(5):3245-52.
  9. Hsu, S.H., Lo, Y.Y., Tung, J.Y., Ko, Y.C., Sun Y.-J, Hung, C.C., Yang, C.W., Tseng, F.G., Fu, C.C., Pan, R.L. Leptospiral outer membrane lipoprotein LipL32 binding on toll-like receptor 2 of renal cells as determined with an atomic force microscope Biochemistry. (2010) 6;49 (26):5408-17.
  10. Chang YW, Chuang YC, Ho YC, Cheng MY, Sun Y.-J., Hsiao CD, Wang C. Crystal structure of Get4/Get5 complex and its interactions with Sgt2, Get3 and Ydj1. J Biol Chem. (2010) 285(13):9962-70.
  11. Hung, K.W., Chang Y.W., Eng, E.T., Chen, J.H., Chen, Y.C., Sun, Y.-J., Hsiao, C.D., Dong, G., Spasov, K.A., Unger, V.M., Huang, T.H. (2010). Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB. J Struct Biol. (2010) 170(3):501-12.
  12. Chan, K.-W., Lee, Y.-J., Wang, C.-H., Huang, H., and Sun, Y.-J.* Single-stranded DNA-binding protein complex from Helicobacter pylori suggests an ssDNA-binding surface. Journal of Molecular Biology (2009) 388, 508-519.
  13. Tsai, K.-L., Lo, Y.-H., Sun, Y.-J. and Hsiao C.-D.,Molecular Interplay between the Replicative Helicase DnaC and Its Loader Protein DnaI from Geobacillus kaustophilus. Journal of Molecular Biology (2009) 388, 508-519
  14. Chan, K.-W., Lee, Y.-J., Wang, C.-H., Huang, H., and Sun, Y.-J.* Single-stranded DNA-binding protein complex from Helicobacter pylori suggests an ssDNA-binding surface. Journal of Molecular Biology (2009) 388, 508-519
  15. Lo, Y.-H., Tsai, K.-L., Sun, Y.-J., Chen, W.-T., Huang C.-Y., and Hsiao C.-D., The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA. Nucleic Acids Research, (2009) 37, 804–814
  16. Tung, J-Y, Chang, M. D.-T., Chou, W.-I., Liu, Y.-Y., Yeh, Y.-H., Chang, F.-Y., Lin, S.-C., Qiu, Z.-L. and Sun,Y.-J.* (2008) Crystal Structures of Starch Binding Domain from Rhizopus oryzae Glucoamylase Reveal a Polysaccharide Binding Path. Biochemical Journal 416, 27-36.
  17. Chu, C.-H., Lai, Y.-J., Huang, H., and Sun, Y.-J.* (2008). Kinetic and structural properties of triosephosphate isomerase from Helicobacter pylori. Proteins: Structure, Function, and Bioinformatics 71, 396-406
  18. Chang, YW, Sun, Y.-J, Wang, C, Hsiao, CD. (2008) Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation. J Biol Chem. 30;283(22):15502-11.