Experimental structural genomics projects will
focus on proteins whose structure cannot be recognized by sequence analysis.
A large fraction of proteins in completed genomes cannot be effectively
characterized by sequence comparison, so these
proteins will be candidates for experimental
work in structural genomics projects.
~ 1/4 of the structures solved will have novel
folds.
this fraction will slowly decrease
It is likely that structure determination
will reveal that nearly half of the proteins
are homologous to a protein already in the
database, despite absence of significant sequence similarity.
Structure determination promises to be an
increasingly effective and efficient means of detecting
homology, and thus suggesting molecular function for proteins.