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Appendix 2: Parameter Files

vdw.parms.amb / vdw.parms.amb.mindock

vdw.parms.amb

Use this parameter file with force-field scoring dock runs.
!  AMBER-based van der Waals parameters (see vdwinfo)
!type      sqrt(A)      sqrt(B)
   1        888.79        24.81    sp2 and sp C
   2       1586.37        35.05    CH3 (united atom)
   3       1128.12        27.96    CH2 (united atom)
   4        769.72        21.49    CH (united atom)
   5        533.20        16.16    sp3 C
   6          0.00         0.00    H on polar atom
   7         85.37         4.13    H on C
   8        735.31        24.25    sp2 and sp N
   9        725.70        20.26    quaternary sp3 N
  10        888.79        24.81    sp3 N
  11        480.19        20.72    sp2 O
  12        500.18        19.68    sp3 O
  13       2454.77        46.86    P
  14       1831.79        40.48    S
  15        251.02        11.92    F
  16       2194.13        46.37    Cl
  17       3885.92        66.31    Br
  18       6817.37        92.86    I
  19        235.24        10.15    Na+ (unhydrated), K+
  20         51.92         5.73    Mg++, Li+, Al+++, M++ (except Ca++)
  21        339.55        14.65    Ca++
  22       1971.47        37.63    Cl- (unhydrated)
  23        762.07        24.38    Lennard-Jones water particle
  24       3885.92        66.31    Si (same numbers as Br)
  25          0.00         0.00    Du/LP (same numbers as H on polar atom)


vdw.parms.amb.mindock

Use this parameter file with all force-field scoring when employing minimization, either during DOCK runs or as a post-DOCK refinement with
dockmin_sim or dockmin_dfp.
!  Use this vdw parameter file when using minimization, either within dock
!  or with a post-dock minimizer (dockmin_sim, dockmin_dfp)
!
!  AMBER-based van der Waals parameters (see vdwinfo)
!  polar H has been made non-volumeless for energy minimization
!type      sqrt(A)      sqrt(B)
   1        888.79        24.81    sp2 and sp C
   2       1586.37        35.05    CH3 (united atom)
   3       1128.12        27.96    CH2 (united atom)
   4        769.72        21.49    CH (united atom)
   5        533.20        16.16    sp3 C
   6          0.37         0.31    H on polar atom
   7         85.37         4.13    H on C
   8        735.31        24.25    sp2 and sp N
   9        725.70        20.26    quaternary sp3 N
  10        888.79        24.81    sp3 N
  11        480.19        20.72    sp2 O
  12        500.18        19.68    sp3 O
  13       2454.77        46.86    P
  14       1831.79        40.48    S
  15        251.02        11.92    F
  16       2194.13        46.37    Cl
  17       3885.92        66.31    Br
  18       6817.37        92.86    I
  19        235.24        10.15    Na+ (unhydrated), K+
  20         51.92         5.73    Mg++, Li+, Al+++, M++ (except Ca++)
  21        339.55        14.65    Ca++
  22       1971.47        37.63    Cl- (unhydrated)
  23        762.07        24.38    Lennard-Jones water particle
  24       3885.92        66.31    Si (same numbers as Br)
  25          0.00         0.00    Du/LP (same numbers as H on polar atom)

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Curator: Daniel Gschwend, gschwend@cgl.ucsf.edu (rev. 1 September 1995)