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HomeWork 3

Search genes associated with colon cancer in human genome. MLH1 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS.
-Deadline- 10/30/2001

	How many hits will you get if you search genes associated with colon cancer in human genome?
	How many loci will you find if you search locus link for human in Genebank?
	Give the locus ID and position of MLH1.
	Find the %ID of nucleotide sequence for its possible orthologs in mouse.
	Find the total number of mutations of MLH1 reported in human gene mutation database.
	Give the DNA sequence of MLH1.
	Give the DNA sequence of E. coli mismatch repair gene mutS.